Morphological and ultrastructural aspects of the cyclical changes of human mammary gland during the menstrual cycle

Analyzing the morphological and ultrastructural features of the mammary gland during the menstrual cycle, the authors observed that in the proliferative phase, the mammary gland consisted of few developed lobules and presented a relative absence of mitotic figures. In this phase, the great majority...

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Detalles Bibliográficos
Autores: Nazário, Afonso Celso Pinto [UNIFESP], Simões, Manuel de Jesus [UNIFESP], Lima, Geraldo Rodrigues de [UNIFESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1994
País:Brasil
Institución:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:inglés
OAI Identifier:oai:repositorio.unifesp.br:11600/346
Acceso en línea:http://dx.doi.org/10.1590/S1516-31801994000200004
http://repositorio.unifesp.br/handle/11600/346
Access Level:acceso abierto
Palabra clave:mammary gland
menstrual cycle
morphology
ultrastructure
Descripción
Sumario:Analyzing the morphological and ultrastructural features of the mammary gland during the menstrual cycle, the authors observed that in the proliferative phase, the mammary gland consisted of few developed lobules and presented a relative absence of mitotic figures. In this phase, the great majority of the epithelial cells contained small, dark, irregular, rich heterochromatinic nuclei. The mammary stroma showed similar findings, presenting dense connective tissue with few enhanced fibroblasts. During the secretory phase, the lobules were well developed and mitotic figures were usually observed. In this phase, the great majority of the ephitelial cells presented clear voluminous, rich euchromatinic nuclei; the stroma consisted of fibroblasts with voluminous nuclei full of euchromatin. There are evident modifications of the mammary tissue according to the phase of the menstrual cycle. The morphological and ultrastructural modifications indicate higher metabolical and mitotic activities during the secretory phase.