Microcystins in water samples from hemodialysis clinics of São Paulo state/Brazil
Cyanobacteria (blue-green algae) are most ancient photosynthetic prokaryotes organisms originated from pre-Cambrian era, which have adapted to several habitats, from thermal springs to humid ground. These organisms appear abundantly in fresh water forming blooms under determined ambient conditions,...
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2004 |
| País: | Brasil |
| Institución: | Instituto Adolfo Lutz |
| Repositorio: | Revista do Instituto Adolfo Lutz (Online) |
| Idioma: | portugués |
| OAI Identifier: | oai:ojs.periodicos.saude.sp.gov.br:article/34860 |
| Acceso en línea: | https://periodicos.saude.sp.gov.br/RIAL/article/view/34860 |
| Access Level: | acceso abierto |
| Palabra clave: | cyanobacteria microcystins hemodialysis water ELISA toxins cianobacterias microcistinas água de hemodiálise toxinas |
| Sumario: | Cyanobacteria (blue-green algae) are most ancient photosynthetic prokaryotes organisms originated from pre-Cambrian era, which have adapted to several habitats, from thermal springs to humid ground. These organisms appear abundantly in fresh water forming blooms under determined ambient conditions, such as high luminosity, high temperature, and high nutrient concentration. Cyanobacteria produce some types of toxins such as microcystins (MC), which are one of the most important one due to its toxicity. Microcystins are heptapeptides formed by five invariable and two variable amino acids. More than 60 microcystins have been chemically identified. It has known that one of these toxins, the MC-LR (leucine, arginine) induces intracellular enzymes (phosphatases) inhibition, causing alteration in the cell structure. Sub-lethal doses of this hepatotoxin have been associated with malignancy development. The aim of the present study was to determine the concentration of microcystins in water used for hemodialysis procedure. Water samples were collected from hemodialysis clinics located in the State of São Paulo - Brazil from April/2002 to March/2003, by means of routine official visit of the Sanitation Inspection Committee. Microcystins concentrations were determined by means of commercially available enzyme immunoassay [ELISA (Envirologix Inc)]. ELISA kit was tested , and a standard curve with... |
|---|