Growth hormone 1 gene (GH1) polymorphisms as possible markers of the production potential of beef cattle using the Brazilian Canchim breed as a model

The growth hormone 1 gene (GH1) is a candidate gene for body weight and weight gain in cattle since it plays a fundamental role in growth regulation. We investigated the GH1gene AluI and DdeI restriction enzyme polymorphisms, located 149 bp apart in the cattle genome, as possible markers of the prod...

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Detalhes bibliográficos
Autores: Silveira, Luiz Guilherme G. [UNESP], Furlan, Luiz R. [UNESP], Curi, Rogério A. [UNESP], Ferraz, André Luiz J. [UNESP], de Alencar, Maurício M., Regitano, Luciana C.A., Martins, Cyntia L. [UNESP], de Beni Arrigoni, Mário [UNESP], Suguisawa, Liliane [UNESP], Silveira, Antônio C. [UNESP], de Oliveira, Henrique N. [UNESP]
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2008
País:Brasil
Recursos:Universidade Estadual Paulista (UNESP)
Repositório:Repositório Institucional da UNESP
Idioma:inglês
OAI Identifier:oai:repositorio.unesp.br:11449/225438
Acesso em linha:http://dx.doi.org/10.1590/S1415-47572008000500012
http://hdl.handle.net/11449/225438
Access Level:Acceso aberto
Palavra-chave:Beef cattle
Candidate gene
Growth hormone
Polymorphism
Descrição
Resumo:The growth hormone 1 gene (GH1) is a candidate gene for body weight and weight gain in cattle since it plays a fundamental role in growth regulation. We investigated the GH1gene AluI and DdeI restriction enzyme polymorphisms, located 149 bp apart in the cattle genome, as possible markers of the production potential of Canchim crossbreed cattle, a 5/8 Charolais (Bos taurus) and 3/8 Nelore (Bos indicus) breed developed in Brazil, by evaluating the birth weight, weaning weight, yearling weight and plasma insulin-like growth factor-1 (IGF-1) concentration of 7 month to 10 months old Canchim calves (n = 204) of known genealogy and which had been genotyped for the AluI and DdeI markers. Our results showed significant effect (p < 0.05) between the homozygous DdeI+/DdeI+ polymorphism and the estimated breeding value for weaning weight (ESB-WW), while the AluI leucine homozygous (L/L) and leucine/valine (L/ V) heterozygous polymorphisms showed no significant effect on the traits studied. The restriction sites of the two enzymes led to the formation of haplotypes which also exerted a significant effect (p < 0.05) on the ESB-WW, with the largest difference being 8.5 kg in favor of the homozygous L plus DdeI+/L plus DdeI+ genotype over the heterozygous L plus DdeI-/V plus DdeI+ genotype. Copyright © 2008, Sociedade Brasileira de Genética.

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