Bioactive flavone dimers from Ouratea multiflora (Ochnaceae)

Chromatographic fractionation of the organic extract from leaves of Ouratea multiflora afforded the flavone dimers heveaflavone, amentoflavone-7¢¢,4¢¢¢-dimethyl eter, podocarpusflavone-A and amentoflavone. Their structures were elucidated from spectral data, including 2D-NMR experiments of the natur...

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Detalles Bibliográficos
Autores: Carbonezi, Carlos Alberto [UNESP], Hamerski, Lidilhone [UNESP], Gunatilaka, A. A. Leslie, Cavalheiro, Alberto José [UNESP], Castro-Gamboa, Ian [UNESP], Silva, Dulce Helena Siqueira [UNESP], Furlan, Maysa [UNESP], Young, Maria Claudia Marx, Lopes, Márcia Nasser [UNESP], Bolzani, Vanderlan da Silva [UNESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2007
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/26309
Acceso en línea:http://dx.doi.org/10.1590/S0102-695X2007000300003
http://hdl.handle.net/11449/26309
Access Level:acceso abierto
Palabra clave:Ochnaceae
Ouratea multiflora
biflavonoids
antibacterial activity
Descripción
Sumario:Chromatographic fractionation of the organic extract from leaves of Ouratea multiflora afforded the flavone dimers heveaflavone, amentoflavone-7¢¢,4¢¢¢-dimethyl eter, podocarpusflavone-A and amentoflavone. Their structures were elucidated from spectral data, including 2D-NMR experiments of the natural substances. Biological activities of all isolates were evaluated, using antimicrobial assay against Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, cytotoxicity assay against mouse lymphoma (L5178) and KB cell lines, TLC screening for acetylcholinesterase inhibitors and antioxidant activity measured by DPPH test.

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