Molecular Epidemiology of Staphylococcus aureus and MRSA in Bedridden Patients and Residents of Long-Term Care Facilities

At present, multidrug-resistant microorganisms are already responsible for community-acquired infections. Methicillin-resistant Staphylococcus aureus (MRSA) poses a serious public health risk worldwide because of the rapid spread and diversification of pandemic clones that are characterized by incre...

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Autores: Silva, Lucas Porangaba [UNESP], Fortaleza, Carlos Magno Castelo Branco [UNESP], Teixeira, Nathalia Bibiana [UNESP], Silva, Luís Thadeo Poianas [UNESP], de Angelis, Carolina Destro [UNESP], Ribeiro de Souza da Cunha, Maria de Lourdes [UNESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/247867
Acceso en línea:http://dx.doi.org/10.3390/antibiotics11111526
http://hdl.handle.net/11449/247867
Access Level:acceso abierto
Palabra clave:bedridden patients
elderly population
long-term care facility
molecular epidemiology
MRSA
Staphylococcus aureus
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spelling Molecular Epidemiology of Staphylococcus aureus and MRSA in Bedridden Patients and Residents of Long-Term Care Facilitiesbedridden patientselderly populationlong-term care facilitymolecular epidemiologyMRSAStaphylococcus aureusAt present, multidrug-resistant microorganisms are already responsible for community-acquired infections. Methicillin-resistant Staphylococcus aureus (MRSA) poses a serious public health risk worldwide because of the rapid spread and diversification of pandemic clones that are characterized by increasing virulence and antimicrobial resistance. The aim of this study was to identify the prevalence and factors associated with nasal, oral and rectal carriage of S. aureus and MRSA in bedridden patients and residents of long-term care facilities for the elderly (LTCFs) in Botucatu, SP, Brazil. Nasal, oral and rectal swab isolates obtained from 226 LTCF residents or home-bedridden patients between 2017 and 2018 were submitted to susceptibility testing, detection of the mecA gene, SCCmec characterization, and molecular typing by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Logistic regression analysis was used to identify risk factors associated with the presence of S. aureus and MRSA. The prevalence of S. aureus and MRSA was 33.6% (n = 76) and 8% (n = 18), respectively. At the nine LTCFs studied, the prevalence of S. aureus ranged from 16.6% to 85.7% and that of MRSA from 13.3% to 25%. Living in an LTCF, male gender, a history of surgeries, and a high Charlson Comorbidity Index score were risk factors associated with S. aureus carriage, while MRSA carriage was positively associated with male gender. This study showed a high prevalence of S. aureus among elderly residents of small (<15 residents) and medium-sized (15–49 residents) LTCFs and a higher prevalence of MRSA in the oropharynx.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Chemical and Biological Sciences Biosciences Institute UNESP—Universidade Estadual Paulista, SPDepartment of Infectology Dermatology Diagnostic Imaging and Radiotherapy Botucatu School of Medicine UNESP—Universidade Estadual Paulista, SPDepartment of Chemical and Biological Sciences Biosciences Institute UNESP—Universidade Estadual Paulista, SPDepartment of Infectology Dermatology Diagnostic Imaging and Radiotherapy Botucatu School of Medicine UNESP—Universidade Estadual Paulista, SPCNPq: 303603Universidade Estadual Paulista (UNESP)2023-07-29T13:28:05Z2023-07-29T13:28:05Z2022-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/antibiotics11111526Antibiotics, v. 11, n. 11, 2022.2079-6382http://hdl.handle.net/11449/24786710.3390/antibiotics111115262-s2.0-85141772166Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAntibioticsinfo:eu-repo/semantics/openAccessSilva, Lucas Porangaba [UNESP]Fortaleza, Carlos Magno Castelo Branco [UNESP]Teixeira, Nathalia Bibiana [UNESP]Silva, Luís Thadeo Poianas [UNESP]de Angelis, Carolina Destro [UNESP]Ribeiro de Souza da Cunha, Maria de Lourdes [UNESP]2025-10-16T10:53:42Zoai:repositorio.unesp.br:11449/247867Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-10-16T10:53:42Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Molecular Epidemiology of Staphylococcus aureus and MRSA in Bedridden Patients and Residents of Long-Term Care Facilities
title Molecular Epidemiology of Staphylococcus aureus and MRSA in Bedridden Patients and Residents of Long-Term Care Facilities
spellingShingle Molecular Epidemiology of Staphylococcus aureus and MRSA in Bedridden Patients and Residents of Long-Term Care Facilities
Silva, Lucas Porangaba [UNESP]
bedridden patients
elderly population
long-term care facility
molecular epidemiology
MRSA
Staphylococcus aureus
title_short Molecular Epidemiology of Staphylococcus aureus and MRSA in Bedridden Patients and Residents of Long-Term Care Facilities
title_full Molecular Epidemiology of Staphylococcus aureus and MRSA in Bedridden Patients and Residents of Long-Term Care Facilities
title_fullStr Molecular Epidemiology of Staphylococcus aureus and MRSA in Bedridden Patients and Residents of Long-Term Care Facilities
title_full_unstemmed Molecular Epidemiology of Staphylococcus aureus and MRSA in Bedridden Patients and Residents of Long-Term Care Facilities
title_sort Molecular Epidemiology of Staphylococcus aureus and MRSA in Bedridden Patients and Residents of Long-Term Care Facilities
dc.creator.none.fl_str_mv Silva, Lucas Porangaba [UNESP]
Fortaleza, Carlos Magno Castelo Branco [UNESP]
Teixeira, Nathalia Bibiana [UNESP]
Silva, Luís Thadeo Poianas [UNESP]
de Angelis, Carolina Destro [UNESP]
Ribeiro de Souza da Cunha, Maria de Lourdes [UNESP]
author Silva, Lucas Porangaba [UNESP]
author_facet Silva, Lucas Porangaba [UNESP]
Fortaleza, Carlos Magno Castelo Branco [UNESP]
Teixeira, Nathalia Bibiana [UNESP]
Silva, Luís Thadeo Poianas [UNESP]
de Angelis, Carolina Destro [UNESP]
Ribeiro de Souza da Cunha, Maria de Lourdes [UNESP]
author_role author
author2 Fortaleza, Carlos Magno Castelo Branco [UNESP]
Teixeira, Nathalia Bibiana [UNESP]
Silva, Luís Thadeo Poianas [UNESP]
de Angelis, Carolina Destro [UNESP]
Ribeiro de Souza da Cunha, Maria de Lourdes [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.subject.por.fl_str_mv bedridden patients
elderly population
long-term care facility
molecular epidemiology
MRSA
Staphylococcus aureus
topic bedridden patients
elderly population
long-term care facility
molecular epidemiology
MRSA
Staphylococcus aureus
description At present, multidrug-resistant microorganisms are already responsible for community-acquired infections. Methicillin-resistant Staphylococcus aureus (MRSA) poses a serious public health risk worldwide because of the rapid spread and diversification of pandemic clones that are characterized by increasing virulence and antimicrobial resistance. The aim of this study was to identify the prevalence and factors associated with nasal, oral and rectal carriage of S. aureus and MRSA in bedridden patients and residents of long-term care facilities for the elderly (LTCFs) in Botucatu, SP, Brazil. Nasal, oral and rectal swab isolates obtained from 226 LTCF residents or home-bedridden patients between 2017 and 2018 were submitted to susceptibility testing, detection of the mecA gene, SCCmec characterization, and molecular typing by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Logistic regression analysis was used to identify risk factors associated with the presence of S. aureus and MRSA. The prevalence of S. aureus and MRSA was 33.6% (n = 76) and 8% (n = 18), respectively. At the nine LTCFs studied, the prevalence of S. aureus ranged from 16.6% to 85.7% and that of MRSA from 13.3% to 25%. Living in an LTCF, male gender, a history of surgeries, and a high Charlson Comorbidity Index score were risk factors associated with S. aureus carriage, while MRSA carriage was positively associated with male gender. This study showed a high prevalence of S. aureus among elderly residents of small (<15 residents) and medium-sized (15–49 residents) LTCFs and a higher prevalence of MRSA in the oropharynx.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-01
2023-07-29T13:28:05Z
2023-07-29T13:28:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/antibiotics11111526
Antibiotics, v. 11, n. 11, 2022.
2079-6382
http://hdl.handle.net/11449/247867
10.3390/antibiotics11111526
2-s2.0-85141772166
url http://dx.doi.org/10.3390/antibiotics11111526
http://hdl.handle.net/11449/247867
identifier_str_mv Antibiotics, v. 11, n. 11, 2022.
2079-6382
10.3390/antibiotics11111526
2-s2.0-85141772166
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Antibiotics
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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score 15.301629

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