Pure Ovarian Leydig Cell Tumors
Pure Leydig cell tumors are rare ovarian steroid cell neoplasms composed entirely or predominantly of Leydig cells. More than 75% of patients present signs of virilization due to overproduction of testosterone. We report the clinical manifestations, diagnosis, and treatment of a case of pure Leydig...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2008 |
| País: | Brasil |
| Institución: | Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
| Repositorio: | Revista Brasileira de Cancerologia (Online) |
| Idioma: | portugués |
| OAI Identifier: | oai:rbc.inca.gov.br:article/1722 |
| Acceso en línea: | https://rbc.inca.gov.br/index.php/revista/article/view/1722 |
| Access Level: | acceso abierto |
| Palabra clave: | Tumor de células de Leydig Neoplasias ovarianas Hiperandrogenismo Virilismo Leydig cell tumors Ovarian neoplasms Hyperandrogenism Virilism |
| Sumario: | Pure Leydig cell tumors are rare ovarian steroid cell neoplasms composed entirely or predominantly of Leydig cells. More than 75% of patients present signs of virilization due to overproduction of testosterone. We report the clinical manifestations, diagnosis, and treatment of a case of pure Leydig cell tumor at the Gynecology Department of Santa Casa de Misericórdia (Mercy Hospital) in Vitória, Espírito Santo State, Brazil, in 2002. The case was a 47-year-old female with progressive signs of virilization for more than five years. Laboratory examination revealed only high levels of serum testosterone. There was no evidence of alteration in adrenal glands during diagnostic imaging. Transvaginal ultrasound showed only a slightly enlarged right ovary, with no radiological sign of tumor. Total hysterectomy and bilateral salpingoophorectomy were performed. Histopathology and immunohistochemistry confirmed the diagnosis of pure Leydig cell tumor. After surgery, testosterone level returned to normal and there was no significant evidence of virilization. |
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