Brazilian propolis promotes immunomodulation on human cells from American Tegumentar Leishmaniasis patients and healthy donors infected with L. braziliensis

American Tegumentar Leishmaniasis (ATL) is an infectious disease caused by Leishmania parasites with ineffective treatment. The properties of propolis have been studied in different experimental studies, however, few works have investigated the effects of propolis on human-derived peripheral blood m...

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Detalhes bibliográficos
Autores: dos Santos Thomazelli, Ana Paula Fortes, Tomiotto-Pellissier, Fernanda, da Silva, Suelen Santos, Panis, Carolina, Orsini, Tatiane Marcusso, Cataneo, Allan Henrique Depieri, Miranda-Sapla, Milena Menegazzo, Custódio, Luiz Antonio, Tatakihara, Vera Lúcia Hideko, Bordignon, Juliano, Silveira, Guilherme Ferreira, Sforcin, José Maurício [UNESP], Pavanelli, Wander Rogério, Conchon-Costa, Ivete
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2017
País:Brasil
Recursos:Universidade Estadual Paulista (UNESP)
Repositório:Repositório Institucional da UNESP
Idioma:inglês
OAI Identifier:oai:repositorio.unesp.br:11449/173858
Acesso em linha:http://dx.doi.org/10.1016/j.cellimm.2016.09.014
http://hdl.handle.net/11449/173858
Access Level:Acceso aberto
Palavra-chave:Human PBMC
IL-10
IL-4
IL-6
In vitro
Th17
Descrição
Resumo:American Tegumentar Leishmaniasis (ATL) is an infectious disease caused by Leishmania parasites with ineffective treatment. The properties of propolis have been studied in different experimental studies, however, few works have investigated the effects of propolis on human-derived peripheral blood mononuclear cells (PBMC) in leishmaniasis models. Thus, we investigate the immunomodulatory effects of propolis treatment on PBMC from ATL patients and on PBMC from healthy donors infected with Leishmania braziliensis. Our data demonstrate that propolis pretreatment shows immunomodulatory effects on both healthy donors and ATL patients adherent cells, increasing IL-4 and IL-17 and decreasing IL-10, in either the presence or absence of the L. braziliensis infection, demonstrating that propolis contributes with the decrease of the inflammation and could also contribute with parasite control.

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