Inhibition of digestive enzymes (α-amylase, α-glucosidase, lipase, trypsin) by aqueous Hibiscus sabdariffa L. (Malvaceae) extract
A considerable portion of the world population uses medicinal plants to treat chronic diseases. In this context, hibiscus (Hibiscus sabdariffa L. - Malvaceae) stands out for its supposed hypoglycemic and slimming effect. The present work aimed to carry out enzyme inhibition tests for aqueous hibiscu...
| Autores: | , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | Brasil |
| Recursos: | Fundação Oswaldo Cruz (FIOCRUZ) |
| Repositorio: | Revista Fitos |
| Idioma: | inglés |
| OAI Identifier: | oai:ojs.revistafitos.far.fiocruz.br:article/1217 |
| Acesso em linha: | https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1217 |
| Access Level: | acceso abierto |
| Palavra-chave: | Hibiscus sabdariffa Glucosidase Diabetes Obesity Molecular docking |
| Resumo: | A considerable portion of the world population uses medicinal plants to treat chronic diseases. In this context, hibiscus (Hibiscus sabdariffa L. - Malvaceae) stands out for its supposed hypoglycemic and slimming effect. The present work aimed to carry out enzyme inhibition tests for aqueous hibiscus extracts, as a possible mechanism of action related to the supposed slimming and hypoglycemic effects. The inhibition of four digestive enzymes (α-amylase, α-glucosidase, lipase and trypsin) was tested before and after exposure to a simulated gastric fluid. In addition, a molecular anchorage study was carried out, in order to highlight possible molecular interactions between target and ligand. The results showed that the aqueous extract of hibiscus, in the proportion 1:10 (w/v), inhibits only α-glucosidase. It was observed that cyanidin-3-sambubioside, has interaction with the enzyme with properties similar to acarbose, which corroborates the possibility of the presence of an inhibitory effect in the aqueous extract of hibiscus. |
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