Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil

The seed oil of Annona salzmannii A. DC. was analyzed by GC-MS and 1 H qNMR, revealing a mixture of unsaturated (80.5%) and saturated (18.7%) fatty acids. Linoleic (45.3%) and oleic (33.5%) acid were the major unsaturated fatty acids identified, while palmitic acid (14.3%) was the major saturated fa...

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Bibliographic Details
Authors: Cristina Lara Ribeiro, Jane, Bruginski, Estevan, Zuccolotto, Tatiana, da Conceição Santos, Alan Diego, Mendes Bomfim, Larissa, Andrade Rocha, Suellen Laila, Barison, Andersson, Sassaki, Guilherme, de Holanda Cavalcanti, Sócrates Cabral, Vilaça Costa, Emmanoel, Botelho Pereira Soares, Milena, Pereira Bezerra, Daniel, Ramos Campos, Francinete
Format: article
Status:Published version
Publication Date:2022
Country:Brasil
Institution:Universidade de São Paulo (USP)
Repository:Brazilian Journal of Pharmaceutical Sciences
Language:English
OAI Identifier:oai:revistas.usp.br:article/201119
Online Access:https://www.revistas.usp.br/bjps/article/view/201119
Access Level:Open access
Keyword:Annona salzmannii. Annonaceae. Larvicidal activity. Cytotoxic activity. Seed oil
Description
Summary:The seed oil of Annona salzmannii A. DC. was analyzed by GC-MS and 1 H qNMR, revealing a mixture of unsaturated (80.5%) and saturated (18.7%) fatty acids. Linoleic (45.3%) and oleic (33.5%) acid were the major unsaturated fatty acids identified, while palmitic acid (14.3%) was the major saturated fatty acid. The larvicidal effects of A. salzmannii seed oil were evaluated against third-instar larvae of Aedes aegypti (Linn.). The oil exhibited moderate larvicidal activity, with aLC50 of 569.77 ppm (95% CI = 408.11 to 825.88 ppm). However, when the cytotoxic effects of the oil were evaluated, no expressive antiproliferative effects were observed in tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia), HL-60 (human promyelocytic leukemia), and non-tumor cell line PBMC (peripheral blood mononuclear cells), with IC50 values > 50 μg·mL-1. This is the first study to evaluate the chemical composition, larvicidal and cytotoxic activity of A. salzmannii seed oil.

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