The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy

Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.

Detalles Bibliográficos
Autores: Honorato, Layla, Witkin, Steven S., Correa, Maria Cássia Mendes, Toscano, Ana Luiza Castro Conde, Linhares, Iara Moreno, Paula, Anderson Vicente de, Paião, Heuder Gustavo Oliveira, Paula, Vanessa Salete de, Lopes, Amanda de Oliveira, Lima, Silvia Helena, Raymundi, Vanessa de Cássia, Ferreira, Noely Evangelista, Silva Junior, Almir Ribeiro da, Abrahim, Karim Yaqub, Silva, Paulo Henrique Braz, Tozetto-Mendoza, Tania Regina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:Brasil
Institución:Fundação Oswaldo Cruz (FIOCRUZ)
Repositorio:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglés
OAI Identifier:oai:arca.fiocruz.br:icict/54952
Acceso en línea:https://arca.fiocruz.br/handle/icict/54952
Access Level:acceso abierto
Palabra clave:Linfócitos CD4+
HIV
Sarcoma de Kaposi
Saliva
Torque teno virus
Anelovírus
id BR_3ea1b98db720b341bca5c6d20dbfe81a
oai_identifier_str oai:arca.fiocruz.br:icict/54952
network_acronym_str BR
network_name_str Brasil
repository_id_str
dc.title.none.fl_str_mv The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy
title The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy
spellingShingle The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy
Honorato, Layla
Linfócitos CD4+
HIV
Sarcoma de Kaposi
Saliva
Torque teno virus
Anelovírus
title_short The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy
title_full The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy
title_fullStr The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy
title_full_unstemmed The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy
title_sort The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy
dc.creator.none.fl_str_mv Honorato, Layla
Witkin, Steven S.
Correa, Maria Cássia Mendes
Toscano, Ana Luiza Castro Conde
Linhares, Iara Moreno
Paula, Anderson Vicente de
Paião, Heuder Gustavo Oliveira
Paula, Vanessa Salete de
Lopes, Amanda de Oliveira
Lima, Silvia Helena
Raymundi, Vanessa de Cássia
Ferreira, Noely Evangelista
Silva Junior, Almir Ribeiro da
Abrahim, Karim Yaqub
Silva, Paulo Henrique Braz
Tozetto-Mendoza, Tania Regina
author Honorato, Layla
author_facet Honorato, Layla
Witkin, Steven S.
Correa, Maria Cássia Mendes
Toscano, Ana Luiza Castro Conde
Linhares, Iara Moreno
Paula, Anderson Vicente de
Paião, Heuder Gustavo Oliveira
Paula, Vanessa Salete de
Lopes, Amanda de Oliveira
Lima, Silvia Helena
Raymundi, Vanessa de Cássia
Ferreira, Noely Evangelista
Silva Junior, Almir Ribeiro da
Abrahim, Karim Yaqub
Silva, Paulo Henrique Braz
Tozetto-Mendoza, Tania Regina
author_role author
author2 Witkin, Steven S.
Correa, Maria Cássia Mendes
Toscano, Ana Luiza Castro Conde
Linhares, Iara Moreno
Paula, Anderson Vicente de
Paião, Heuder Gustavo Oliveira
Paula, Vanessa Salete de
Lopes, Amanda de Oliveira
Lima, Silvia Helena
Raymundi, Vanessa de Cássia
Ferreira, Noely Evangelista
Silva Junior, Almir Ribeiro da
Abrahim, Karim Yaqub
Silva, Paulo Henrique Braz
Tozetto-Mendoza, Tania Regina
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.other.none.fl_str_mv Linfócitos CD4+
HIV
Sarcoma de Kaposi
Saliva
Torque teno virus
Anelovírus
topic Linfócitos CD4+
HIV
Sarcoma de Kaposi
Saliva
Torque teno virus
Anelovírus
description Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-10-01T16:16:21Z
dc.date.available.fl_str_mv 2022-10-01T16:16:21Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv HONORATO, Layla et al. The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy. Frontiers in Medicine, v. 8, Article 809312, p. 1 - 6, Jan. 2022.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/54952
dc.identifier.issn.none.fl_str_mv 2298-858X
dc.identifier.doi.none.fl_str_mv 10.3389/fmed.2021.809312
identifier_str_mv HONORATO, Layla et al. The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy. Frontiers in Medicine, v. 8, Article 809312, p. 1 - 6, Jan. 2022.
2298-858X
10.3389/fmed.2021.809312
url https://arca.fiocruz.br/handle/icict/54952
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers in Medicine
publisher.none.fl_str_mv Frontiers in Medicine
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://arca.fiocruz.br/bitstreams/cbb7376e-0f76-41a3-bbb0-8f718d54e540/download
https://arca.fiocruz.br/bitstreams/163150ff-93e6-4e2a-81b0-bd9c8a19114c/download
https://arca.fiocruz.br/bitstreams/abf886c8-afcc-4a08-b4b9-b39c02592a83/download
https://arca.fiocruz.br/bitstreams/bc910aae-284d-4f99-9ee5-bcdf9d5b124f/download
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
646322b780cf5c6677e13683295da325
82bdcc2371d087a96a784f32bf9d248d
7233e5874bd9b1d7c6e527bfa715a4a1
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1853674091230265344
spelling 2022-10-01T16:16:21Z2022-10-01T16:16:21Z2022HONORATO, Layla et al. The Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapy. Frontiers in Medicine, v. 8, Article 809312, p. 1 - 6, Jan. 2022.2298-858Xhttps://arca.fiocruz.br/handle/icict/5495210.3389/fmed.2021.809312engFrontiers in MedicineLinfócitos CD4+HIVSarcoma de KaposiSalivaTorque teno virusAnelovírusThe Torque Teno Virus Titer in Saliva Reflects the Level of Circulating CD4+ T Lymphocytes and HIV in Individuals Undergoing Antiretroviral Maintenance Therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil / Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, USA.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Instituto de Infectologia Emílio Ribas. Hospital Dia. São Paulo, SP, Brasil.Universidade de São Paulo. Departamento de Ginecologia e Obstetrícia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil / Universidade de São Paulo. Faculdade de Odontologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Departamento de Doenças Infecciosas. Laboratório de Virologia. São Paulo, SP, Brasil.Introduction: Torque teno virus (TTV) is a non-pathogenic virus present in body fluids. Its titer in the circulation increases in association with immune suppression, such as in HIV-infected individuals.We evaluated if the TTV titer in saliva fromHIV-positive individuals undergoing antiretroviral therapy (ART) was related to the circulating CD4+ T lymphocyte concentration and the HIV titer. Methods: Saliva was collected from 276 asymptomatic individuals undergoing ART, and an additional 48 individuals positive for AIDS-associated Kaposi's Sarcoma (AIDSKS). The salivary TTV titer was measured by gene amplification analysis. The circulating CD4+ T lymphocyte and HIV levels were obtained by chart review. Results: TTV was detectable in saliva from 80%of the asymptomatic subjects and 87% of those with AIDS-KS. In the asymptomatic group the median log10 TTV titer/ml was 3.3 in 200 males vs. 2.4 in 76 females (p < 0.0001). TTV titer/ml was 3.7 when HIV was acquired by intravenous drug usage, 3.2 when by sexual acquisition and 2.4 when blood transfusion acquired. The salivary TTV titer was inversely correlated with the circulating CD4+ T lymphocyte level (p < 0.0001) and positively correlated with the circulating HIV concentration (p = 0.0005). The median salivary TTV titer and circulating HIV titer were higher, and the CD4+ count was lower, in individuals positive for AIDS-KS than in the asymptomatic subjects (p < 0.0001).info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZHonorato, LaylaWitkin, Steven S.Correa, Maria Cássia MendesToscano, Ana Luiza Castro CondeLinhares, Iara MorenoPaula, Anderson Vicente dePaião, Heuder Gustavo OliveiraPaula, Vanessa Salete deLopes, Amanda de OliveiraLima, Silvia HelenaRaymundi, Vanessa de CássiaFerreira, Noely EvangelistaSilva Junior, Almir Ribeiro daAbrahim, Karim YaqubSilva, Paulo Henrique BrazTozetto-Mendoza, Tania ReginaLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/cbb7376e-0f76-41a3-bbb0-8f718d54e540/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALVanessaPaula_LauraHonorato_etal_IOC_2022.pdfVanessaPaula_LauraHonorato_etal_IOC_2022.pdfapplication/pdf261752https://arca.fiocruz.br/bitstreams/163150ff-93e6-4e2a-81b0-bd9c8a19114c/download646322b780cf5c6677e13683295da325MD52trueAnonymousREADTEXTVanessaPaula_LauraHonorato_etal_IOC_2022.pdf.txtVanessaPaula_LauraHonorato_etal_IOC_2022.pdf.txtExtracted texttext/plain34415https://arca.fiocruz.br/bitstreams/abf886c8-afcc-4a08-b4b9-b39c02592a83/download82bdcc2371d087a96a784f32bf9d248dMD515falseAnonymousREADTHUMBNAILVanessaPaula_LauraHonorato_etal_IOC_2022.pdf.jpgVanessaPaula_LauraHonorato_etal_IOC_2022.pdf.jpgGenerated Thumbnailimage/jpeg41810https://arca.fiocruz.br/bitstreams/bc910aae-284d-4f99-9ee5-bcdf9d5b124f/download7233e5874bd9b1d7c6e527bfa715a4a1MD516falseAnonymousREADicict/549522025-12-16 06:37:17.654open.accessoai:arca.fiocruz.br:icict/54952https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-12-16T09:37:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
score 15,301629

Similares en LA Referencia