Data Augmentation in Histopathological Classification: An Analysis Exploring GANs with XAI and Vision Transformers

Generative adversarial networks (GANs) create images by pitting a generator (G) against a discriminator (D) network, aiming to find a balance between the networks. However, achieving this balance is difficult because G is trained based on just one value representing D’s prediction, and only D can ac...

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Detalhes bibliográficos
Autores: Rozendo, Guilherme Botazzo [UNESP], Garcia, Bianca Lançoni de Oliveira [UNESP], Borgue, Vinicius Augusto Toreli [UNESP], Lumini, Alessandra, Tosta, Thaína Aparecida Azevedo, Nascimento, Marcelo Zanchetta do, Neves, Leandro Alves [UNESP]
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2024
País:Brasil
Recursos:Universidade Estadual Paulista (UNESP)
Repositório:Repositório Institucional da UNESP
Idioma:inglês
OAI Identifier:oai:repositorio.unesp.br:11449/303070
Acesso em linha:http://dx.doi.org/10.3390/app14188125
https://hdl.handle.net/11449/303070
Access Level:Acceso aberto
Palavra-chave:data augmentation
explainable artificial intelligence
GAN training
generative adversarial networks
histopathological classification
vision transformers
Descrição
Resumo:Generative adversarial networks (GANs) create images by pitting a generator (G) against a discriminator (D) network, aiming to find a balance between the networks. However, achieving this balance is difficult because G is trained based on just one value representing D’s prediction, and only D can access image features. We introduce a novel approach for training GANs using explainable artificial intelligence (XAI) to enhance the quality and diversity of generated images in histopathological datasets. We leverage XAI to extract feature information from D and incorporate it into G via the loss function, a unique strategy not previously explored in this context. We demonstrate that this approach enriches the training with relevant information and promotes improved quality and more variability in the artificial images, decreasing the FID by up to 32.7% compared to traditional methods. In the data augmentation task, these images improve the classification accuracy of Transformer models by up to 3.81% compared to models without data augmentation and up to 3.01% compared to traditional GAN data augmentation. The Saliency method provides G with the most informative feature information. Overall, our work highlights the potential of XAI for enhancing GAN training and suggests avenues for further exploration in this field.