Resveratrol reduces chronic inflammation and improves insulin action in the myocardium of high-fat diet-induced obese rats
ObjectiveTo evaluate the effects of resveratrol on insulin signaling and inflammation pathway in the myocardium of high-fat diet-induced obese rats. MethodsThirty Wistar rats were divided into a control group (n=10, standard diet), obese group (n=10, high-fat diet), and obese supplemented with resve...
| Autores: | , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | Brasil |
| Recursos: | Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
| Repositorio: | Revista de Nutrição |
| Idioma: | inglés |
| OAI Identifier: | oai:ojs.periodicos.puc-campinas.edu.br:article/8297 |
| Acesso em linha: | https://periodicos.puc-campinas.edu.br/nutricao/article/view/8297 |
| Access Level: | acceso abierto |
| Palavra-chave: | Obesity Resveratrol Insulin resistance Inflammation Obesidade Resistência à insulina Inflamação |
| Resumo: | ObjectiveTo evaluate the effects of resveratrol on insulin signaling and inflammation pathway in the myocardium of high-fat diet-induced obese rats. MethodsThirty Wistar rats were divided into a control group (n=10, standard diet), obese group (n=10, high-fat diet), and obese supplemented with resveratrol group (n=10, 20 mg/kg/day) for eight weeks. An insulin tolerance test was performed at the end of the study period “0” (without insulin), 5, 10, 15, 20, 25, and 30 minutes after an intraperitoneal injection of insulin (2 U/kg). Body and epididymal adipose tissue were weighed. Fragments of the myocardium were extracted for Western blot analyses of insulin pathway and proinflammatory molecules. ResultsResveratrol increased the rate of glucose disappearance, phosphorylation of the insulin receptor, insulin receptor substrate 1, and protein kinase B; and reduced expression of tumor necrosis factor alpha and of the moleculesinvolved in proinflammatory signal transduction, namely Ikappa B kinase and nuclear factor kappa B complex. The results also suggest that higher insulin sensitivity and lower levels of proinflammatory molecules occurred regardless of weight and epididymal adipose tissue loss. ConclusionResveratrol increases insulin action and reduces inflammatory molecules in the myocardium. |
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