Is there any relationship between gene expression of tumor antigens and CD4+ T cells in multiple myeloma?
Aim: The present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor‐infiltrating T cells. Materials & methods:MAGE‐C1/CT‐7, MAGEA3/6, NY‐ESO‐1, LAGE‐1 and GAGE expression were evaluated in 46 bone marrow multiple myeloma (MM)...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | Brasil |
| Institución: | Instituição de Ensino Superior e de Pesquisa (INSPER) |
| Repositorio: | Repositório Institucional da INSPER |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.insper.edu.br:11224/3986 |
| Acceso en línea: | https://repositorio.insper.edu.br/handle/11224/3986 https://doi.org/10.2217/imt.14.24 |
| Access Level: | acceso abierto |
| Palabra clave: | cancer/testis antigen multiple myeloma Th17 Treg |
| Sumario: | Aim: The present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor‐infiltrating T cells. Materials & methods:MAGE‐C1/CT‐7, MAGEA3/6, NY‐ESO‐1, LAGE‐1 and GAGE expression were evaluated in 46 bone marrow multiple myeloma (MM) aspirates by RT‐PCR. Expression of FOXP3/CTLA4 and RORyt, as markers for Tregs and Th17 cells, respectively, was investigated by quantitative PCR. Results:MAGEC1/CT7 was expressed in 66% of MM samples. We did not find correlation between the presence of single CTA and expression of CTLA4 or RORyt neither expression of CD4+ T‐cell markers and the number of CTA simultaneously expressed in the tumor. However, we did observe a correlation between the percentage of plasma cells and the number of CTAs expressed in the patients' bone marrow. Conclusion: Although CTAs and immunomodulatory CD4+ T cells represent potential targets for immunotherapy in MM, we did not find association among expression of such genes in MM |
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