Dopamine Transporter Imaging Using Tc-99m-TRODAT-1 SPECT in Parkinson's Disease

Background: Although the decrease in striatal dopamine transporter (DAT) density has been described in North American, European, and Asian Parkinson's disease (PD) patients, studies on this issue are required in the rest of the world. This study examined the diagnostic utility of DAT imaging in...

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Detalles Bibliográficos
Autores: Bor-Seng-Shu, Edson, Felício, André Carvalho [UNIFESP], Braga-Neto, Pedro [UNIFESP], Batista, Ilza Rosa [UNIFESP], Paiva, Wellingson Silva, Andrade, Daniel Ciampi de, Teixeira, Manoel Jacobsen, Franco de Andrade, Luiz Augusto, Barsottini, Orlando Graziani Povoas [UNIFESP], Shih, Ming Chi, Bressan, Rodrigo Affonseca [UNIFESP], Ferraz, Henrique Ballalai [UNIFESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Brasil
Institución:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:inglés
OAI Identifier:oai:repositorio.unifesp.br:11600/44876
Acceso en línea:http://dx.doi.org/10.12659/MSM.890522
http://repositorio.unifesp.br/handle/11600/44876
Access Level:acceso abierto
Palabra clave:Molecular Imaging
Parkinson Disease - radionuclide imaging
Tomography, Emission-Computed, Single-Photon
Descripción
Sumario:Background: Although the decrease in striatal dopamine transporter (DAT) density has been described in North American, European, and Asian Parkinson's disease (PD) patients, studies on this issue are required in the rest of the world. This study examined the diagnostic utility of DAT imaging in Brazilian PD patients.Material/Methods: Twenty PD patients (13 males, 7 females, median age: 62 years, median age at disease onset: 56 years, median disease duration: 5 years, and median UPDRS-III score: 29) and 9 age-and sex-matched healthy subjects underwent single-photon emission computerized tomography (SPECT) using Tc-99m-TRODAT-1.Results: PD patients showed a significant decrease in the striatum, caudate nucleus, and putamen DAT densities compared with data from healthy subjects. Striatal Tc-99m-TRODAT-1 bindings had the highest diagnostic accuracy compared to those estimates from caudate nucleus and putamen. For the diagnosis of PD, a striatal Tc-99m-TRODAT-1 binding cut-off value of 0.90 was associated with a sensitivity of 100% and a specificity of 89%. There was no significant difference between striatal Tc-99m-TRODAT-1 binding values provided by different readers, contrary to Tc-99m-TRODAT-1 binding estimates in the caudate nucleus.Conclusions: Striatal DAT imaging using Tc-99m-TRODAT-1 can be considered a marker for differentiating PD patients from healthy individuals, with a good interobserver reproducibility.

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