Cytotoxicity and Antibacterial Activity of Silver Complexes Bearing Semicarbazones and Triphenylphosphine

The present work aimed to evaluate the biological activities of the silver (I) complexes, with the formulae [Ag(L)(PPh3)2]+ and [Ag(L)2]+ (L=(E)-2-((E)-3-phenylallylidene) hydrazine-1-carboxamide – CSC and (2E)-2-[(3E)-4-phenylbut-3-en-2-ylidene]-hydrazinecarboxamide – BSC). Four new silver(I) compo...

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Detalles Bibliográficos
Autores: Almeida, Vitor Y. G., Rocha, Josias S., Felix, Débora P., Oliveira, Gabriela P., Lima, Mauro A., Farias, Renan L. [UNESP], Zanetti, Renan D. [UNESP], Netto, Adelino V. G. [UNESP], Zambom, Carolina R. [UNESP], Garrido, Saulo S. [UNESP], Rocha, Fillipe V.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/206948
Acceso en línea:http://dx.doi.org/10.1002/slct.202004093
http://hdl.handle.net/11449/206948
Access Level:acceso abierto
Palabra clave:Antibacterial
Antiproliferation
DNA interaction
NMR spectroscopy
Silver (I)
Descripción
Sumario:The present work aimed to evaluate the biological activities of the silver (I) complexes, with the formulae [Ag(L)(PPh3)2]+ and [Ag(L)2]+ (L=(E)-2-((E)-3-phenylallylidene) hydrazine-1-carboxamide – CSC and (2E)-2-[(3E)-4-phenylbut-3-en-2-ylidene]-hydrazinecarboxamide – BSC). Four new silver(I) compounds were synthesized and characterized by NMR 1H, 13C-{1H}, 31P, IR, and UV-Vis spectroscopies, molar conductivity, and elemental analysis (CNH). High cytotoxicity was found for all complexes being more active than cisplatin in the tested cell lines. The antibacterial assay demonstrated that the compounds without phosphine groups presented high levels of inhibition (80 %) at 70.4 uM against the Gram-positive and Gram-negative bacteria strains. The DNA interactions were investigated by UV-Vis DNA titration, electrophoresis, and circular dichroism experiments. Data showed that the compounds did not interact with DNA in the tested conditions. However, the compounds have provided important information about the structural features that are needed in order to design new silver (I) complexes with biological activities.

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