[DUPLICADO] Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report
Objective: the aim of this report is to warn that sodium valproate used during pregnancy can produce craniosynostosis in the newborn, particularly trigonocephaly. Method: we describe a case of trigonocephaly in a six month-old girl, daughter of a young non-smoker couple, whose mother had used phenob...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2001 |
| País: | Brasil |
| Institución: | Universidade de Taubaté (UNITAU) |
| Repositorio: | Repositório Institucional da UNITAU |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.unitau.br:20.500.11874/2933 |
| Acceso en línea: | http://repositorio.unitau.br/jspui/handle/20.500.11874/2933 |
| Access Level: | acceso abierto |
| Palabra clave: | Valproic Acid Teratogenic Effect Craniosynostoses Metopic Suture Intracranial-Pressure Antiepileptic Drugs Risk Children Volume Series Acid Neurosciences Psychiatry Neurosciences & Neurology |
| Sumario: | Objective: the aim of this report is to warn that sodium valproate used during pregnancy can produce craniosynostosis in the newborn, particularly trigonocephaly. Method: we describe a case of trigonocephaly in a six month-old girl, daughter of a young non-smoker couple, whose mother had used phenobarbital 100 mg daily and sodium valproate 500 mg twice daily during the whole pregnancy. We also review current literature about this topic. Result: bone sclerosis over the metopic suture was confirmed during surgery. Bibliographical review yields previous reports on valproate teratogenicity, mainly determining metopic suture craniosynostosis. Conclusion: sodium valproate used during pregnancy can produce craniosynostosis by teratogenic effect, specially trigonocephaly (premature fusion of metopic suture). |
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