[DUPLICADO] Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report
Objective: the aim of this report is to warn that sodium valproate used during pregnancy can produce craniosynostosis in the newborn, particularly trigonocephaly. Method: we describe a case of trigonocephaly in a six month-old girl, daughter of a young non-smoker couple, whose mother had used phenob...
| Authors: | , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2001 |
| Country: | Brasil |
| Institution: | Universidade de Taubaté (UNITAU) |
| Repository: | Repositório Institucional da UNITAU |
| Language: | Portuguese |
| OAI Identifier: | oai:repositorio.unitau.br:20.500.11874/2933 |
| Online Access: | http://repositorio.unitau.br/jspui/handle/20.500.11874/2933 |
| Access Level: | Open access |
| Keyword: | Valproic Acid Teratogenic Effect Craniosynostoses Metopic Suture Intracranial-Pressure Antiepileptic Drugs Risk Children Volume Series Acid Neurosciences Psychiatry Neurosciences & Neurology |
| Summary: | Objective: the aim of this report is to warn that sodium valproate used during pregnancy can produce craniosynostosis in the newborn, particularly trigonocephaly. Method: we describe a case of trigonocephaly in a six month-old girl, daughter of a young non-smoker couple, whose mother had used phenobarbital 100 mg daily and sodium valproate 500 mg twice daily during the whole pregnancy. We also review current literature about this topic. Result: bone sclerosis over the metopic suture was confirmed during surgery. Bibliographical review yields previous reports on valproate teratogenicity, mainly determining metopic suture craniosynostosis. Conclusion: sodium valproate used during pregnancy can produce craniosynostosis by teratogenic effect, specially trigonocephaly (premature fusion of metopic suture). |
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