Papel das Yops secretadas por Yersinia sobre a resposta imune do hospedeiro
The genus Yersinia contains three species pathogenic to humans: Y. pestis, Y. enterocolitica e Y. pseudotuberculosis. The pathogenicity of Yersinia is linked to the presence of a 70-kb virulence plasmid (pYV) that is common to the three species and codifies a type III secretion system and a set of v...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2005 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.unesp.br:11449/68629 |
| Acceso en línea: | http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/405 http://hdl.handle.net/11449/68629 |
| Access Level: | acceso abierto |
| Palabra clave: | Antibodies Cytokine Phagocytosis Yersinia Yops bacterial protein unclassified drug Yersinia outer protein B Yersinia outer protein D Yersinia outer protein H Yersinia outer protein J Yersinia outer protein M Yersinia outer protein O Yersinia outer protein T cytosol immune response nonhuman phagocytosis review Yersinia enterocolitica Yersinia pestis Yersinia pseudotuberculosis |
| Sumario: | The genus Yersinia contains three species pathogenic to humans: Y. pestis, Y. enterocolitica e Y. pseudotuberculosis. The pathogenicity of Yersinia is linked to the presence of a 70-kb virulence plasmid (pYV) that is common to the three species and codifies a type III secretion system and a set of virulence proteins, including those known as Yersinia outer proteins (Yops), that are exported by this system when the bacteria encounter host cells. Two Yops translocators (YopB and YopD) are inserted into the host plasma membrane and transport six effectors (YopO, YopH, YopM, YopJ and YopT) across the membrane into the cytosol of the host cell. The Yops effectors interfere with multiple signaling pathways of the infected cell, affecting both the innate and adaptive immune responses. This article focuses on the role of Yops in the modulation of the host immune response. |
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