Renin–angiotensin system contributes to naive T-cell migration in vivo
2016-04-30
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | Brasil |
| Institución: | Fundação Oswaldo Cruz (FIOCRUZ) |
| Repositorio: | Repositório Institucional da FIOCRUZ (ARCA) |
| Idioma: | inglés |
| OAI Identifier: | oai:arca.fiocruz.br:icict/12105 |
| Acceso en línea: | https://arca.fiocruz.br/handle/icict/12105 |
| Access Level: | acceso abierto |
| Palabra clave: | Renin–angiotensin system Angiotensin receptors Adaptive immunity Lymphoid organs Chemokine Quimiocinas Linfóide Sistema Renina-Angiotensina Receptores de Angiotensina |
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Renin–angiotensin system contributes to naive T-cell migration in vivo |
| title |
Renin–angiotensin system contributes to naive T-cell migration in vivo |
| spellingShingle |
Renin–angiotensin system contributes to naive T-cell migration in vivo Silva Filho, J. L. Renin–angiotensin system Angiotensin receptors Adaptive immunity Lymphoid organs Chemokine Quimiocinas Linfóide Sistema Renina-Angiotensina Receptores de Angiotensina |
| title_short |
Renin–angiotensin system contributes to naive T-cell migration in vivo |
| title_full |
Renin–angiotensin system contributes to naive T-cell migration in vivo |
| title_fullStr |
Renin–angiotensin system contributes to naive T-cell migration in vivo |
| title_full_unstemmed |
Renin–angiotensin system contributes to naive T-cell migration in vivo |
| title_sort |
Renin–angiotensin system contributes to naive T-cell migration in vivo |
| dc.creator.none.fl_str_mv |
Silva Filho, J. L. Souza, M. C. Henriques, M. G. Morrot, A. Savino, Wilson Neves, C. Caruso Pinheiro, A. A. S. |
| author |
Silva Filho, J. L. |
| author_facet |
Silva Filho, J. L. Souza, M. C. Henriques, M. G. Morrot, A. Savino, Wilson Neves, C. Caruso Pinheiro, A. A. S. |
| author_role |
author |
| author2 |
Souza, M. C. Henriques, M. G. Morrot, A. Savino, Wilson Neves, C. Caruso Pinheiro, A. A. S. |
| author2_role |
author author author author author author |
| dc.subject.en.none.fl_str_mv |
Renin–angiotensin system Angiotensin receptors Adaptive immunity Lymphoid organs Chemokine |
| topic |
Renin–angiotensin system Angiotensin receptors Adaptive immunity Lymphoid organs Chemokine Quimiocinas Linfóide Sistema Renina-Angiotensina Receptores de Angiotensina |
| dc.subject.decs.none.fl_str_mv |
Quimiocinas Linfóide Sistema Renina-Angiotensina Receptores de Angiotensina |
| description |
2016-04-30 |
| publishDate |
2015 |
| dc.date.accessioned.fl_str_mv |
2015-11-03T13:10:04Z |
| dc.date.issued.fl_str_mv |
2015 |
| dc.date.available.fl_str_mv |
2016-05-01T07:30:06Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
SILVA FILHO, J. L. et al. Renin–angiotensin system contributes to naive T-cell migration in vivo. Archives of Biochemistry and Biophysics, v.573, p.1-13, May 2015. |
| dc.identifier.uri.fl_str_mv |
https://arca.fiocruz.br/handle/icict/12105 |
| dc.identifier.issn.none.fl_str_mv |
0003-9861 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.abb.2015.02.035 |
| dc.identifier.eissn.none.fl_str_mv |
1096-0384 |
| identifier_str_mv |
SILVA FILHO, J. L. et al. Renin–angiotensin system contributes to naive T-cell migration in vivo. Archives of Biochemistry and Biophysics, v.573, p.1-13, May 2015. 0003-9861 10.1016/j.abb.2015.02.035 1096-0384 |
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https://arca.fiocruz.br/handle/icict/12105 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
ScienceDirect |
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ScienceDirect |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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Repositório Institucional da FIOCRUZ (ARCA) |
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2015-11-03T13:10:04Z2016-05-01T07:30:06Z2015SILVA FILHO, J. L. et al. Renin–angiotensin system contributes to naive T-cell migration in vivo. Archives of Biochemistry and Biophysics, v.573, p.1-13, May 2015.0003-9861https://arca.fiocruz.br/handle/icict/1210510.1016/j.abb.2015.02.0351096-0384engScienceDirectRenin–angiotensin system contributes to naive T-cell migration in vivoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2016-04-30Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico/MCT. Instituto Nacional de Ciência e Tecnologia em Biologia e Bioimagem. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Conselho Nacional de Desenvolvimento Científico e Tecnológico/MCT. Instituto Nacional para Pesquisa Translacional em Saúde e Ambiente na Região Amazônica. Brasil.Angiotensin II (Ang II) plays an important role in the regulation of the T-cell response during inflammation. However, the cellular mechanisms underlying the regulation of lymphocytes under physiologic conditions have not yet been studied. Here, we tested the influence of Ang II on T-cell migration using T cells from BALB/c mice. The results obtained in vivo showed that when Ang II production or the AT1 receptor were blocked, T-cell counts were enhanced in blood but decreased in the spleen. The significance of these effects was confirmed by observing that these cells migrate, through fibronectin to Ang II via the AT1 receptor. We also observed a gradient of Ang II from peripheral blood to the spleen, which explains its chemotactic effect on this organ. The following cellular mechanisms were identified to mediate the Ang II effect: upregulation of the chemokine receptor CCR9; upregulation of the adhesion molecule CD62L; increased production of the chemokines CCL19 and CCL25 in the spleen. These results indicate that the higher levels of Ang II in the spleen and AT1 receptor activation contribute to migration of naive T cells to the spleen, which expands our understanding on how the Ang II/AT1 receptor axis contributes to adaptive immunity.Renin–angiotensin systemAngiotensin receptorsAdaptive immunityLymphoid organsChemokineQuimiocinasLinfóideSistema Renina-AngiotensinaReceptores de Angiotensinainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZSilva Filho, J. L.Souza, M. C.Henriques, M. G.Morrot, A.Savino, WilsonNeves, C. CarusoPinheiro, A. A. 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