Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats.

Background: The metabolic syndrome (MS) is characterized by variable coexistence of metabolic and pathophysiological alterations which are important risk factors for developing of type II diabetes and/or cardiovascular diseases. Increased of MS patients in worldwide has stimulated the development of...

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Autores: Castro, Uberdan Guilherme Mendes de, Santos, Robson Augusto Souza dos, Silva, Marcelo Eustáquio, Lima, Wanderson Geraldo de, Santos, Maria José Campagnole dos, Alzamora, Andréia Carvalho
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:Brasil
Institución:Universidade Federal de Ouro Preto (UFOP)
Repositorio:Repositório Institucional da UFOP
Idioma:inglés
OAI Identifier:oai:repositorio.ufop.br:123456789/4353
Acceso en línea:http://www.repositorio.ufop.br/handle/123456789/4353
https://doi.org/10.1186/1476-511X-12-136
Access Level:acceso abierto
Palabra clave:High fat diet
High fructose diet
Metabolic syndrome
Rats
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spelling Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats.High fat dietHigh fructose dietMetabolic syndromeRatsBackground: The metabolic syndrome (MS) is characterized by variable coexistence of metabolic and pathophysiological alterations which are important risk factors for developing of type II diabetes and/or cardiovascular diseases. Increased of MS patients in worldwide has stimulated the development of experimental models. However, it is still challenging to find an dietetic model that most closely approximates human MS and, in addition, is not yet fully established the effect of different diets of MS in lipid metabolism in rats of different ages. The aim of this study was to evaluate the effect of different diets of MS in lipid metabolism and ectopic fat deposition and define the most appropriate diet for inducing the characteristic disturbances of the human MS in rats of different ages. Methods: Young (4 weeks old) and adult rats (12 weeks old) were given a high-fat (FAT) or high-fructose diet (FRU) for 13 weeks and biochemical, physiological, histological and biometric parameters were evaluated. Results: In young rats, the FAT diet induced increased mean blood pressure (MAP) and heart rate (HR), body weight after 6 to 10 weeks, and in the 13th week, increased the liver, mesenteric, retroperitoneal and epididymal fat weights,fasting glucose, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and reduced HDL cholesterol; and also induced non-alcoholic fatty liver disease (NAFLD) and renal inflammatory infiltrates. In adult rats, the FRU diet induced transient elevations of MAP and HR in the 6th week, and, at 13 weeks, increased fasting glucose, triglycerides, total cholesterol, AST and ALT; increased liver, kidneys and retroperitoneal fat weights; and induced macrovesicular and microvesicular NAFLD, the presence of fat cells in the kidney, glomerular sclerosis, and liver and kidney inflammation. Additionally, the FAT and FRU diets induced, respectively, increases in liver glycogen in adults and young rats. Conclusions: Our data show that FRU diet in adult rats causes biggest change on metabolism of serum lipids and lipid accumulation in liver and kidney, while the FAT diet in young rats induces elevation of MAP and HR and higher increased visceral lipid stores, constituting the best nutritional interventions to induce MS in rats.2015-01-22T15:17:19Z2015-01-22T15:17:19Z2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfCASTRO, U. G. M. et al. Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats. Lipids in Health and Disease, v. 12, p. 136, 2013. Disponível em: <http://www.lipidworld.com/content/pdf/1476-511X-12-136.pdf>. Acesso em: 08 nov. 2014.1476-511Xhttp://www.repositorio.ufop.br/handle/123456789/4353https://doi.org/10.1186/1476-511X-12-136ark:/61566/0013000004788Authors of articles published in Lipids in Health and Disease are the copyright holders of their articles and have granted to any third party, in advance and in perpetuity, the right to use, reproduce or disseminate the article, according to the BioMed Central copyright and license agreemen. Fonte: Lipids in Health and Disease <http://www.lipidworld.com/about>. Acesso em: 28 nov. 2014.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPCastro, Uberdan Guilherme Mendes deSantos, Robson Augusto Souza dosSilva, Marcelo EustáquioLima, Wanderson Geraldo deSantos, Maria José Campagnole dosAlzamora, Andréia Carvalho2024-11-10T15:44:57Zoai:repositorio.ufop.br:123456789/4353Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332024-11-10T15:44:57Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats.
title Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats.
spellingShingle Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats.
Castro, Uberdan Guilherme Mendes de
High fat diet
High fructose diet
Metabolic syndrome
Rats
title_short Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats.
title_full Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats.
title_fullStr Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats.
title_full_unstemmed Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats.
title_sort Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats.
dc.creator.none.fl_str_mv Castro, Uberdan Guilherme Mendes de
Santos, Robson Augusto Souza dos
Silva, Marcelo Eustáquio
Lima, Wanderson Geraldo de
Santos, Maria José Campagnole dos
Alzamora, Andréia Carvalho
author Castro, Uberdan Guilherme Mendes de
author_facet Castro, Uberdan Guilherme Mendes de
Santos, Robson Augusto Souza dos
Silva, Marcelo Eustáquio
Lima, Wanderson Geraldo de
Santos, Maria José Campagnole dos
Alzamora, Andréia Carvalho
author_role author
author2 Santos, Robson Augusto Souza dos
Silva, Marcelo Eustáquio
Lima, Wanderson Geraldo de
Santos, Maria José Campagnole dos
Alzamora, Andréia Carvalho
author2_role author
author
author
author
author
dc.subject.por.fl_str_mv High fat diet
High fructose diet
Metabolic syndrome
Rats
topic High fat diet
High fructose diet
Metabolic syndrome
Rats
description Background: The metabolic syndrome (MS) is characterized by variable coexistence of metabolic and pathophysiological alterations which are important risk factors for developing of type II diabetes and/or cardiovascular diseases. Increased of MS patients in worldwide has stimulated the development of experimental models. However, it is still challenging to find an dietetic model that most closely approximates human MS and, in addition, is not yet fully established the effect of different diets of MS in lipid metabolism in rats of different ages. The aim of this study was to evaluate the effect of different diets of MS in lipid metabolism and ectopic fat deposition and define the most appropriate diet for inducing the characteristic disturbances of the human MS in rats of different ages. Methods: Young (4 weeks old) and adult rats (12 weeks old) were given a high-fat (FAT) or high-fructose diet (FRU) for 13 weeks and biochemical, physiological, histological and biometric parameters were evaluated. Results: In young rats, the FAT diet induced increased mean blood pressure (MAP) and heart rate (HR), body weight after 6 to 10 weeks, and in the 13th week, increased the liver, mesenteric, retroperitoneal and epididymal fat weights,fasting glucose, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and reduced HDL cholesterol; and also induced non-alcoholic fatty liver disease (NAFLD) and renal inflammatory infiltrates. In adult rats, the FRU diet induced transient elevations of MAP and HR in the 6th week, and, at 13 weeks, increased fasting glucose, triglycerides, total cholesterol, AST and ALT; increased liver, kidneys and retroperitoneal fat weights; and induced macrovesicular and microvesicular NAFLD, the presence of fat cells in the kidney, glomerular sclerosis, and liver and kidney inflammation. Additionally, the FAT and FRU diets induced, respectively, increases in liver glycogen in adults and young rats. Conclusions: Our data show that FRU diet in adult rats causes biggest change on metabolism of serum lipids and lipid accumulation in liver and kidney, while the FAT diet in young rats induces elevation of MAP and HR and higher increased visceral lipid stores, constituting the best nutritional interventions to induce MS in rats.
publishDate 2013
dc.date.none.fl_str_mv 2013
2015-01-22T15:17:19Z
2015-01-22T15:17:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv CASTRO, U. G. M. et al. Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats. Lipids in Health and Disease, v. 12, p. 136, 2013. Disponível em: <http://www.lipidworld.com/content/pdf/1476-511X-12-136.pdf>. Acesso em: 08 nov. 2014.
1476-511X
http://www.repositorio.ufop.br/handle/123456789/4353
https://doi.org/10.1186/1476-511X-12-136
dc.identifier.dark.fl_str_mv ark:/61566/0013000004788
identifier_str_mv CASTRO, U. G. M. et al. Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats. Lipids in Health and Disease, v. 12, p. 136, 2013. Disponível em: <http://www.lipidworld.com/content/pdf/1476-511X-12-136.pdf>. Acesso em: 08 nov. 2014.
1476-511X
ark:/61566/0013000004788
url http://www.repositorio.ufop.br/handle/123456789/4353
https://doi.org/10.1186/1476-511X-12-136
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
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