Deleterious effects of gestational diabetes mellitus on the characteristics of the rectus abdominis muscle associated with pregnancy-specific urinary incontinence
Aims: To evaluate the effects of gestational diabetes mellitus (GDM) on the structural characteristics of the rectus abdominis muscle (RAM) and its indirect effects on pregnancy-specific urinary incontinence (PSUI). Methods: A total of 92 pregnant women were divided into four groups, according to th...
| Autores: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.unesp.br:11449/200818 |
| Acceso en línea: | http://dx.doi.org/10.1016/j.diabres.2020.108315 http://hdl.handle.net/11449/200818 |
| Access Level: | acceso abierto |
| Palabra clave: | Collagen Gestational diabetes mellitus Pregnancy-specific urinary incontinence Skeletal muscle Urinary incontinence |
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| dc.title.none.fl_str_mv |
Deleterious effects of gestational diabetes mellitus on the characteristics of the rectus abdominis muscle associated with pregnancy-specific urinary incontinence |
| title |
Deleterious effects of gestational diabetes mellitus on the characteristics of the rectus abdominis muscle associated with pregnancy-specific urinary incontinence |
| spellingShingle |
Deleterious effects of gestational diabetes mellitus on the characteristics of the rectus abdominis muscle associated with pregnancy-specific urinary incontinence Vesentini, Giovana [UNESP] Collagen Gestational diabetes mellitus Pregnancy-specific urinary incontinence Skeletal muscle Urinary incontinence |
| title_short |
Deleterious effects of gestational diabetes mellitus on the characteristics of the rectus abdominis muscle associated with pregnancy-specific urinary incontinence |
| title_full |
Deleterious effects of gestational diabetes mellitus on the characteristics of the rectus abdominis muscle associated with pregnancy-specific urinary incontinence |
| title_fullStr |
Deleterious effects of gestational diabetes mellitus on the characteristics of the rectus abdominis muscle associated with pregnancy-specific urinary incontinence |
| title_full_unstemmed |
Deleterious effects of gestational diabetes mellitus on the characteristics of the rectus abdominis muscle associated with pregnancy-specific urinary incontinence |
| title_sort |
Deleterious effects of gestational diabetes mellitus on the characteristics of the rectus abdominis muscle associated with pregnancy-specific urinary incontinence |
| dc.creator.none.fl_str_mv |
Vesentini, Giovana [UNESP] Barbosa, Angélica M.P. [UNESP] Floriano, Juliana F. [UNESP] Felisbino, Sérgio L. [UNESP] Costa, Sarah M.B. [UNESP] Piculo, Fernanda [UNESP] Marini, Gabriela [UNESP] Nunes, Sthefanie K. [UNESP] Reyes, David R.A. [UNESP] Marcondes, João P.C. [UNESP] Hallur, Raghavendra L.S. [UNESP] Rozza, Ariane L. [UNESP] Magalhães, Cláudia G. [UNESP] Costa, Roberto [UNESP] Abbade, Joelcio F. [UNESP] Corrente, José E. [UNESP] Calderon, Iracema M.P. [UNESP] Matheus, Selma M.M. [UNESP] Rudge, Marilza V.C. [UNESP] |
| author |
Vesentini, Giovana [UNESP] |
| author_facet |
Vesentini, Giovana [UNESP] Barbosa, Angélica M.P. [UNESP] Floriano, Juliana F. [UNESP] Felisbino, Sérgio L. [UNESP] Costa, Sarah M.B. [UNESP] Piculo, Fernanda [UNESP] Marini, Gabriela [UNESP] Nunes, Sthefanie K. [UNESP] Reyes, David R.A. [UNESP] Marcondes, João P.C. [UNESP] Hallur, Raghavendra L.S. [UNESP] Rozza, Ariane L. [UNESP] Magalhães, Cláudia G. [UNESP] Costa, Roberto [UNESP] Abbade, Joelcio F. [UNESP] Corrente, José E. [UNESP] Calderon, Iracema M.P. [UNESP] Matheus, Selma M.M. [UNESP] Rudge, Marilza V.C. [UNESP] |
| author_role |
author |
| author2 |
Barbosa, Angélica M.P. [UNESP] Floriano, Juliana F. [UNESP] Felisbino, Sérgio L. [UNESP] Costa, Sarah M.B. [UNESP] Piculo, Fernanda [UNESP] Marini, Gabriela [UNESP] Nunes, Sthefanie K. [UNESP] Reyes, David R.A. [UNESP] Marcondes, João P.C. [UNESP] Hallur, Raghavendra L.S. [UNESP] Rozza, Ariane L. [UNESP] Magalhães, Cláudia G. [UNESP] Costa, Roberto [UNESP] Abbade, Joelcio F. [UNESP] Corrente, José E. [UNESP] Calderon, Iracema M.P. [UNESP] Matheus, Selma M.M. [UNESP] Rudge, Marilza V.C. [UNESP] |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Sagrado Coração |
| dc.subject.por.fl_str_mv |
Collagen Gestational diabetes mellitus Pregnancy-specific urinary incontinence Skeletal muscle Urinary incontinence |
| topic |
Collagen Gestational diabetes mellitus Pregnancy-specific urinary incontinence Skeletal muscle Urinary incontinence |
| description |
Aims: To evaluate the effects of gestational diabetes mellitus (GDM) on the structural characteristics of the rectus abdominis muscle (RAM) and its indirect effects on pregnancy-specific urinary incontinence (PSUI). Methods: A total of 92 pregnant women were divided into four groups, according to their clinical conditions: non-GDM continent, non-GDM associated PSUI, GDM continent and GDM associated PSUI. The muscle morphometry (histochemistry and immunohistochemistry) for the fiber types and collagen fiber distribution, the ultrastructural analysis (transmission electron microscopy), the protein expression of fiber types and calcium signaling (Western blotting), and the content of types I and III collagen fiber (ELISA) in RAM collected at delivery were assessed. Results: The GDM groups presented a significantly increased number of slow fibers and slow-twitch oxidative fiber expression; decreased fiber area, number of fast fibers, and area of collagen; an increase in central nuclei; ultrastructural alterations with focal lesion areas such as myeloid structures, sarcomere disorganization, and mitochondrial alteration. The PSUI groups presented a considerable decrease in types I and III collagen contents and the localization of collagen fiber. Conclusions: Our data reveal that GDM causes morphological, biochemical and physiological changes in the RAM, and this might predispose women to PSUI. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-12-12T02:16:51Z 2020-12-12T02:16:51Z 2020-08-01 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.diabres.2020.108315 Diabetes Research and Clinical Practice, v. 166. 1872-8227 0168-8227 http://hdl.handle.net/11449/200818 10.1016/j.diabres.2020.108315 2-s2.0-85088633211 |
| url |
http://dx.doi.org/10.1016/j.diabres.2020.108315 http://hdl.handle.net/11449/200818 |
| identifier_str_mv |
Diabetes Research and Clinical Practice, v. 166. 1872-8227 0168-8227 10.1016/j.diabres.2020.108315 2-s2.0-85088633211 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Diabetes Research and Clinical Practice |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
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UNESP |
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Repositório Institucional da UNESP |
| collection |
Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
| repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
| _version_ |
1853672083393871872 |
| spelling |
Deleterious effects of gestational diabetes mellitus on the characteristics of the rectus abdominis muscle associated with pregnancy-specific urinary incontinenceCollagenGestational diabetes mellitusPregnancy-specific urinary incontinenceSkeletal muscleUrinary incontinenceAims: To evaluate the effects of gestational diabetes mellitus (GDM) on the structural characteristics of the rectus abdominis muscle (RAM) and its indirect effects on pregnancy-specific urinary incontinence (PSUI). Methods: A total of 92 pregnant women were divided into four groups, according to their clinical conditions: non-GDM continent, non-GDM associated PSUI, GDM continent and GDM associated PSUI. The muscle morphometry (histochemistry and immunohistochemistry) for the fiber types and collagen fiber distribution, the ultrastructural analysis (transmission electron microscopy), the protein expression of fiber types and calcium signaling (Western blotting), and the content of types I and III collagen fiber (ELISA) in RAM collected at delivery were assessed. Results: The GDM groups presented a significantly increased number of slow fibers and slow-twitch oxidative fiber expression; decreased fiber area, number of fast fibers, and area of collagen; an increase in central nuclei; ultrastructural alterations with focal lesion areas such as myeloid structures, sarcomere disorganization, and mitochondrial alteration. The PSUI groups presented a considerable decrease in types I and III collagen contents and the localization of collagen fiber. Conclusions: Our data reveal that GDM causes morphological, biochemical and physiological changes in the RAM, and this might predispose women to PSUI.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Perinatal Diabetes Research Center University Hospital Botucatu Medical School Univ Estadual Paulista_UNESPSão Paulo State University (UNESP) Botucatu Medical School Department of Gynecology and ObstetricsSão Paulo State University (UNESP) School of Philosophy and Sciences Department of Physical Therapy and Occupational TherapySão Paulo State University (UNESP) Institute of Biosciences Department of MorphologyUniversidade Sagrado Coração Department of Health SciencesSão Paulo State University (UNESP) Institute of Biosciences Biostatistics DepartmentSão Paulo State University (UNESP) Institute of Biosciences Department of AnatomyPerinatal Diabetes Research Center University Hospital Botucatu Medical School Univ Estadual Paulista_UNESPSão Paulo State University (UNESP) Botucatu Medical School Department of Gynecology and ObstetricsSão Paulo State University (UNESP) School of Philosophy and Sciences Department of Physical Therapy and Occupational TherapySão Paulo State University (UNESP) Institute of Biosciences Department of MorphologySão Paulo State University (UNESP) Institute of Biosciences Biostatistics DepartmentSão Paulo State University (UNESP) Institute of Biosciences Department of AnatomyFAPESP: 2014/26852-6FAPESP: 2016/09710-9Universidade Estadual Paulista (Unesp)Universidade Sagrado Coração2020-12-12T02:16:51Z2020-12-12T02:16:51Z2020-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.diabres.2020.108315Diabetes Research and Clinical Practice, v. 166.1872-82270168-8227http://hdl.handle.net/11449/20081810.1016/j.diabres.2020.1083152-s2.0-85088633211Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengDiabetes Research and Clinical Practiceinfo:eu-repo/semantics/openAccessVesentini, Giovana [UNESP]Barbosa, Angélica M.P. [UNESP]Floriano, Juliana F. [UNESP]Felisbino, Sérgio L. [UNESP]Costa, Sarah M.B. [UNESP]Piculo, Fernanda [UNESP]Marini, Gabriela [UNESP]Nunes, Sthefanie K. [UNESP]Reyes, David R.A. [UNESP]Marcondes, João P.C. [UNESP]Hallur, Raghavendra L.S. [UNESP]Rozza, Ariane L. [UNESP]Magalhães, Cláudia G. [UNESP]Costa, Roberto [UNESP]Abbade, Joelcio F. [UNESP]Corrente, José E. [UNESP]Calderon, Iracema M.P. [UNESP]Matheus, Selma M.M. [UNESP]Rudge, Marilza V.C. [UNESP]2025-10-21T05:27:26Zoai:repositorio.unesp.br:11449/200818Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-10-21T05:27:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
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15,301603 |