Long-term treatment with clozapine and verbal memory performance in schizophrenia

Clozapine is more efficacious than first-generation antipsychotics for positive and negative symptoms, although it is related with serious adverse effects. Because of this profile, it could also have an impact on cognition. Therefore, we evaluated learning ability of 31 treatment-resistant individua...

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Detalhes bibliográficos
Autores: Czepielewski, Letícia Sanguinetti, Londero, Marina Dalla Barba, Sousa, Mathias Hasse de, Perin, Carolina Petry, Maldonado, Helena Carvalho, Claudino, Felipe Cesar de Almeida, Gama, Clarissa Severino
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:Brasil
Recursos:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositorio:Repositório Institucional da UFRGS
Idioma:inglés
OAI Identifier:oai:www.lume.ufrgs.br:10183/201440
Acesso em linha:http://hdl.handle.net/10183/201440
Access Level:acceso abierto
Palavra-chave:Clozapina
Esquizofrenia
Antipsicóticos
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spelling 2019-11-08T03:43:14Z20182215-0013http://hdl.handle.net/10183/201440001073498Clozapine is more efficacious than first-generation antipsychotics for positive and negative symptoms, although it is related with serious adverse effects. Because of this profile, it could also have an impact on cognition. Therefore, we evaluated learning ability of 31 treatment-resistant individuals with SZ using clozapine uninterruptedly for 18.23 ± 4.71 years and 26 non-treatment-resistant using other antipsychotics that never used clozapine. Long-term treatment with clozapine did not improve verbal learning ability better than other antipsychotics. Although clozapine has a unique profile for reducing clinical symptoms, it may not have an additional benefit for cognition when started later on the course of schizophrenia.application/pdfengSchizophrenia research : cognition. New York. Vol. 12 (June 2018), p. 40-41ClozapinaEsquizofreniaAntipsicóticosLong-term treatment with clozapine and verbal memory performance in schizophreniaEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSCzepielewski, Letícia SanguinettiLondero, Marina Dalla BarbaSousa, Mathias Hasse dePerin, Carolina PetryMaldonado, Helena CarvalhoClaudino, Felipe Cesar de AlmeidaGama, Clarissa SeverinoTEXT001073498.pdf.txt001073498.pdf.txtExtracted Texttext/plain10323http://www.lume.ufrgs.br/bitstream/10183/201440/2/001073498.pdf.txt07de551cde879806a7984440fae09f9aMD52ORIGINAL001073498.pdfTexto completo (inglês)application/pdf164040http://www.lume.ufrgs.br/bitstream/10183/201440/1/001073498.pdfa9bc2453f53413bbed94ca71492c3b6aMD5110183/2014402023-11-05 04:24:30.083987oai:www.lume.ufrgs.br:10183/201440Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2023-11-05T06:24:30Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Long-term treatment with clozapine and verbal memory performance in schizophrenia
title Long-term treatment with clozapine and verbal memory performance in schizophrenia
spellingShingle Long-term treatment with clozapine and verbal memory performance in schizophrenia
Czepielewski, Letícia Sanguinetti
Clozapina
Esquizofrenia
Antipsicóticos
title_short Long-term treatment with clozapine and verbal memory performance in schizophrenia
title_full Long-term treatment with clozapine and verbal memory performance in schizophrenia
title_fullStr Long-term treatment with clozapine and verbal memory performance in schizophrenia
title_full_unstemmed Long-term treatment with clozapine and verbal memory performance in schizophrenia
title_sort Long-term treatment with clozapine and verbal memory performance in schizophrenia
dc.creator.none.fl_str_mv Czepielewski, Letícia Sanguinetti
Londero, Marina Dalla Barba
Sousa, Mathias Hasse de
Perin, Carolina Petry
Maldonado, Helena Carvalho
Claudino, Felipe Cesar de Almeida
Gama, Clarissa Severino
author Czepielewski, Letícia Sanguinetti
author_facet Czepielewski, Letícia Sanguinetti
Londero, Marina Dalla Barba
Sousa, Mathias Hasse de
Perin, Carolina Petry
Maldonado, Helena Carvalho
Claudino, Felipe Cesar de Almeida
Gama, Clarissa Severino
author_role author
author2 Londero, Marina Dalla Barba
Sousa, Mathias Hasse de
Perin, Carolina Petry
Maldonado, Helena Carvalho
Claudino, Felipe Cesar de Almeida
Gama, Clarissa Severino
author2_role author
author
author
author
author
author
dc.subject.por.fl_str_mv Clozapina
Esquizofrenia
Antipsicóticos
topic Clozapina
Esquizofrenia
Antipsicóticos
description Clozapine is more efficacious than first-generation antipsychotics for positive and negative symptoms, although it is related with serious adverse effects. Because of this profile, it could also have an impact on cognition. Therefore, we evaluated learning ability of 31 treatment-resistant individuals with SZ using clozapine uninterruptedly for 18.23 ± 4.71 years and 26 non-treatment-resistant using other antipsychotics that never used clozapine. Long-term treatment with clozapine did not improve verbal learning ability better than other antipsychotics. Although clozapine has a unique profile for reducing clinical symptoms, it may not have an additional benefit for cognition when started later on the course of schizophrenia.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-11-08T03:43:14Z
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dc.identifier.issn.pt_BR.fl_str_mv 2215-0013
dc.identifier.nrb.pt_BR.fl_str_mv 001073498
identifier_str_mv 2215-0013
001073498
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Schizophrenia research : cognition. New York. Vol. 12 (June 2018), p. 40-41
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