Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia

The distribution of genetic polymorphisms of chemokine receptors CCR5-D32, CCR2-64I and chemokine (SDF1-3 A) mutations were studied in 110 Human Immunodeficiency Virus type 1 (HIV-1) seropositive individuals (seropositive group) and 139 seronegative individuals (seronegative group) from the populati...

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Autores: CARVALHAES, Fernanda Andreza de Pinho Lott, CARDOSO, Greice de Lemos, VALLINOTO, Antonio Carlos Rosário, MACHADO, Luiz Fernando Almeida, ISHAK, Marluísa de Oliveira Guimarães, ISHAK, Ricardo, GUERREIRO, João Farias
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2005
País:Brasil
Institución:Universidade Federal do Pará (UFPA)
Repositorio:Repositório Institucional da UFPA
Idioma:inglés
OAI Identifier:oai:repositorio.ufpa.br:2011/3595
Acceso en línea:http://repositorio.ufpa.br/jspui/handle/2011/3595
Access Level:acceso abierto
Palabra clave:Polimorfismo genético
Receptor CCR2
Receptor CCR5
Receptor SDF1
HIV-1
Síndrome de Imunodeficiência Adquirida
Frequência do gene
Belém - PA
Pará - Estado
Amazônia brasileira
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dc.title.pt_BR.fl_str_mv Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia
title Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia
spellingShingle Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia
CARVALHAES, Fernanda Andreza de Pinho Lott
Polimorfismo genético
Receptor CCR2
Receptor CCR5
Receptor SDF1
HIV-1
Síndrome de Imunodeficiência Adquirida
Frequência do gene
Belém - PA
Pará - Estado
Amazônia brasileira
title_short Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia
title_full Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia
title_fullStr Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia
title_full_unstemmed Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia
title_sort Frequencies of CCR5-D32, CCR2-64I and SDF1-3'A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia
dc.creator.none.fl_str_mv CARVALHAES, Fernanda Andreza de Pinho Lott
CARDOSO, Greice de Lemos
VALLINOTO, Antonio Carlos Rosário
MACHADO, Luiz Fernando Almeida
ISHAK, Marluísa de Oliveira Guimarães
ISHAK, Ricardo
GUERREIRO, João Farias
author CARVALHAES, Fernanda Andreza de Pinho Lott
author_facet CARVALHAES, Fernanda Andreza de Pinho Lott
CARDOSO, Greice de Lemos
VALLINOTO, Antonio Carlos Rosário
MACHADO, Luiz Fernando Almeida
ISHAK, Marluísa de Oliveira Guimarães
ISHAK, Ricardo
GUERREIRO, João Farias
author_role author
author2 CARDOSO, Greice de Lemos
VALLINOTO, Antonio Carlos Rosário
MACHADO, Luiz Fernando Almeida
ISHAK, Marluísa de Oliveira Guimarães
ISHAK, Ricardo
GUERREIRO, João Farias
author2_role author
author
author
author
author
author
dc.subject.por.fl_str_mv Polimorfismo genético
Receptor CCR2
Receptor CCR5
Receptor SDF1
HIV-1
Síndrome de Imunodeficiência Adquirida
Frequência do gene
Belém - PA
Pará - Estado
Amazônia brasileira
topic Polimorfismo genético
Receptor CCR2
Receptor CCR5
Receptor SDF1
HIV-1
Síndrome de Imunodeficiência Adquirida
Frequência do gene
Belém - PA
Pará - Estado
Amazônia brasileira
description The distribution of genetic polymorphisms of chemokine receptors CCR5-D32, CCR2-64I and chemokine (SDF1-3 A) mutations were studied in 110 Human Immunodeficiency Virus type 1 (HIV-1) seropositive individuals (seropositive group) and 139 seronegative individuals (seronegative group) from the population of the northern Brazilian city of Belém which is the capital of the state of Pará in the Brazilian Amazon. The CCR5-D32 mutation was found in the two groups at similar frequencies, i.e. 2.2% for the seronegative group and 2.7% for the seropositive group. The frequencies of the SDF1-3 A mutation were 21.0% for the seronegative group and 15.4% for the seropositive group, and the CCR2-64I allele was found at frequencies of 12.5% for the seronegative group and 5.4% for the seropositive group. Genotype distributions were consistent with Hardy-Weinberg expectations in both groups, suggesting that none of the three mutations has a detectable selective effect. Difference in the allelic and genotypic frequencies was statistically significant for the CCR2 locus, the frequency in the seronegative group being twice that found in the seropositive group. This finding may indicate a protective effect of the CCR2-64I mutation in relation to HIV transmission. However, considering that the CCR2-64I mutation has been more strongly associated with a decreased risk for progression for AIDS than to the resistance to the HIV infection, this could reflect an aspect of population structure or a Type I error.
publishDate 2005
dc.date.issued.fl_str_mv 2005-12
dc.date.accessioned.fl_str_mv 2013-03-26T15:19:03Z
dc.date.available.fl_str_mv 2013-03-26T15:19:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHAES, Fernanda Andreza de Pinho Lott, et al. Frequencies of CCR5-D32, CCR2-64I and SDF1-3’A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia. Genetics and Molecular Biology. São Paulo, v. 28, n. 4, p. 665-669, out./dez. 2005. Disponível em: <http://www.scielo.br/pdf/gmb/v28n4/a04v28n4.pdf>. Acesso em: 25 mar. 2013. <http://dx.doi.org/10.1590/S1415-47572005000500004>.
dc.identifier.uri.fl_str_mv http://repositorio.ufpa.br/jspui/handle/2011/3595
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1415-4757
identifier_str_mv CARVALHAES, Fernanda Andreza de Pinho Lott, et al. Frequencies of CCR5-D32, CCR2-64I and SDF1-3’A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia. Genetics and Molecular Biology. São Paulo, v. 28, n. 4, p. 665-669, out./dez. 2005. Disponível em: <http://www.scielo.br/pdf/gmb/v28n4/a04v28n4.pdf>. Acesso em: 25 mar. 2013. <http://dx.doi.org/10.1590/S1415-47572005000500004>.
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institution UFPA
reponame_str Repositório Institucional da UFPA
collection Repositório Institucional da UFPA
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spelling 2013-03-26T15:19:03Z2013-03-26T15:19:03Z2005-12CARVALHAES, Fernanda Andreza de Pinho Lott, et al. Frequencies of CCR5-D32, CCR2-64I and SDF1-3’A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia. Genetics and Molecular Biology. São Paulo, v. 28, n. 4, p. 665-669, out./dez. 2005. Disponível em: <http://www.scielo.br/pdf/gmb/v28n4/a04v28n4.pdf>. Acesso em: 25 mar. 2013. <http://dx.doi.org/10.1590/S1415-47572005000500004>.1678-46851415-4757http://repositorio.ufpa.br/jspui/handle/2011/3595The distribution of genetic polymorphisms of chemokine receptors CCR5-D32, CCR2-64I and chemokine (SDF1-3 A) mutations were studied in 110 Human Immunodeficiency Virus type 1 (HIV-1) seropositive individuals (seropositive group) and 139 seronegative individuals (seronegative group) from the population of the northern Brazilian city of Belém which is the capital of the state of Pará in the Brazilian Amazon. The CCR5-D32 mutation was found in the two groups at similar frequencies, i.e. 2.2% for the seronegative group and 2.7% for the seropositive group. The frequencies of the SDF1-3 A mutation were 21.0% for the seronegative group and 15.4% for the seropositive group, and the CCR2-64I allele was found at frequencies of 12.5% for the seronegative group and 5.4% for the seropositive group. Genotype distributions were consistent with Hardy-Weinberg expectations in both groups, suggesting that none of the three mutations has a detectable selective effect. Difference in the allelic and genotypic frequencies was statistically significant for the CCR2 locus, the frequency in the seronegative group being twice that found in the seropositive group. This finding may indicate a protective effect of the CCR2-64I mutation in relation to HIV transmission. However, considering that the CCR2-64I mutation has been more strongly associated with a decreased risk for progression for AIDS than to the resistance to the HIV infection, this could reflect an aspect of population structure or a Type I error.Submitted by Samira Prince (prince@ufpa.br) on 2013-03-25T16:10:39Z No. of bitstreams: 2 license_rdf: 23599 bytes, checksum: 9e2b7f6edbd693264102b96ece20428a (MD5) Artigo_FrequenciesCCR5-D32.pdf: 57976 bytes, checksum: b0d6a6153a6599862c017a39c432df4b (MD5)Approved for entry into archive by Ana Rosa Silva(arosa@ufpa.br) on 2013-03-26T15:19:03Z (GMT) No. of bitstreams: 2 license_rdf: 23599 bytes, checksum: 9e2b7f6edbd693264102b96ece20428a (MD5) Artigo_FrequenciesCCR5-D32.pdf: 57976 bytes, checksum: b0d6a6153a6599862c017a39c432df4b (MD5)Made available in DSpace on 2013-03-26T15:19:03Z (GMT). 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