Early choroidal and retinal changes detected by swept-source oct in type 2 diabetes and their association with diabetic kidney disease : a longitudinal prospective study

Background To evaluate structural changes in retina and choroid in patients with type 2 diabetes (T2D) and their association with diabetic kidney disease (DKD). Methods T2D patients with mild or no diabetic retinopathy (DR) were followed for 3 years using structural SS-OCT and OCT angiography (OCT-A...

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Autores: Silva, Monica Oliveira da, Chaves, Anne Elise Cruz do Carmo, Gobbato, Glauber Corrêa, Lavinsky, Fábio, Lavinsky, Daniel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:Brasil
Institución:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositorio:Repositório Institucional da UFRGS
Idioma:inglés
OAI Identifier:oai:www.lume.ufrgs.br:10183/289106
Acceso en línea:http://hdl.handle.net/10183/289106
Access Level:acceso abierto
Palabra clave:Diabetes mellitus tipo 2
Retinopatia diabética
Nefropatias diabéticas
Diabetes mellitus type 2
Diabetic nephropathy
Diabetic retinopathy
Retinal thickness
Choroidal thickness
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spelling 2025-03-27T06:41:55Z20241471-2415http://hdl.handle.net/10183/289106001243868Background To evaluate structural changes in retina and choroid in patients with type 2 diabetes (T2D) and their association with diabetic kidney disease (DKD). Methods T2D patients with mild or no diabetic retinopathy (DR) were followed for 3 years using structural SS-OCT and OCT angiography (OCT-A) taken every 6 months. Parameters were compared longitudinally and according to the DKD status on baseline. Results One hundred and sixty eyes from 80 patients were followed for 3 years, 72 with no DKD (nDKD) at baseline and 88 with DKD. Trend analysis of T2D showed signifcant thinning in GCL+and circumpapillary retinal fber neural layer (cRFNL), choroid, and decreased vascular density (VD) in superfcial plexus and central choriocapillaris with foveal avascular zone (FAZ) enlargement. Patients with no DKD on baseline presented more signifcant declines in retinal center and choroidal thickness, increased FAZ and loss of nasal and temporal choriocapillaris volume. In addition, the nDKD group had worse glycemic control and renal parameters at the end of the study. Conclusion Our data suggests the potential existence of early and progressive neurovascular damage in the retina and choroid of patients with Type 2 Diabetes (T2D) who have either no or mild Diabetic Retinopathy (DR). The progression of neurovascular damage appears to be correlated with parameters related to glycemic control and renal damage.application/pdfengBMC ophthalmology. London. Vol. 24 (2024), 85, 10 p.Diabetes mellitus tipo 2Retinopatia diabéticaNefropatias diabéticasDiabetes mellitus type 2Diabetic nephropathyDiabetic retinopathyRetinal thicknessChoroidal thicknessEarly choroidal and retinal changes detected by swept-source oct in type 2 diabetes and their association with diabetic kidney disease : a longitudinal prospective studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSSilva, Monica Oliveira daChaves, Anne Elise Cruz do CarmoGobbato, Glauber CorrêaLavinsky, FábioLavinsky, DanielTEXT001243868.pdf.txt001243868.pdf.txtExtracted Texttext/plain35209http://www.lume.ufrgs.br/bitstream/10183/289106/2/001243868.pdf.txteb30ce2e29897c7f326bb6b853fadabaMD52ORIGINAL001243868.pdfTexto completo (inglês)application/pdf1763624http://www.lume.ufrgs.br/bitstream/10183/289106/1/001243868.pdf599337bfd23da3be6fb18af4e88549ecMD5110183/2891062025-03-28 06:43:47.706233oai:www.lume.ufrgs.br:10183/289106Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2025-03-28T09:43:47Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Early choroidal and retinal changes detected by swept-source oct in type 2 diabetes and their association with diabetic kidney disease : a longitudinal prospective study
title Early choroidal and retinal changes detected by swept-source oct in type 2 diabetes and their association with diabetic kidney disease : a longitudinal prospective study
spellingShingle Early choroidal and retinal changes detected by swept-source oct in type 2 diabetes and their association with diabetic kidney disease : a longitudinal prospective study
Silva, Monica Oliveira da
Diabetes mellitus tipo 2
Retinopatia diabética
Nefropatias diabéticas
Diabetes mellitus type 2
Diabetic nephropathy
Diabetic retinopathy
Retinal thickness
Choroidal thickness
title_short Early choroidal and retinal changes detected by swept-source oct in type 2 diabetes and their association with diabetic kidney disease : a longitudinal prospective study
title_full Early choroidal and retinal changes detected by swept-source oct in type 2 diabetes and their association with diabetic kidney disease : a longitudinal prospective study
title_fullStr Early choroidal and retinal changes detected by swept-source oct in type 2 diabetes and their association with diabetic kidney disease : a longitudinal prospective study
title_full_unstemmed Early choroidal and retinal changes detected by swept-source oct in type 2 diabetes and their association with diabetic kidney disease : a longitudinal prospective study
title_sort Early choroidal and retinal changes detected by swept-source oct in type 2 diabetes and their association with diabetic kidney disease : a longitudinal prospective study
dc.creator.none.fl_str_mv Silva, Monica Oliveira da
Chaves, Anne Elise Cruz do Carmo
Gobbato, Glauber Corrêa
Lavinsky, Fábio
Lavinsky, Daniel
author Silva, Monica Oliveira da
author_facet Silva, Monica Oliveira da
Chaves, Anne Elise Cruz do Carmo
Gobbato, Glauber Corrêa
Lavinsky, Fábio
Lavinsky, Daniel
author_role author
author2 Chaves, Anne Elise Cruz do Carmo
Gobbato, Glauber Corrêa
Lavinsky, Fábio
Lavinsky, Daniel
author2_role author
author
author
author
dc.subject.por.fl_str_mv Diabetes mellitus tipo 2
Retinopatia diabética
Nefropatias diabéticas
topic Diabetes mellitus tipo 2
Retinopatia diabética
Nefropatias diabéticas
Diabetes mellitus type 2
Diabetic nephropathy
Diabetic retinopathy
Retinal thickness
Choroidal thickness
dc.subject.eng.fl_str_mv Diabetes mellitus type 2
Diabetic nephropathy
Diabetic retinopathy
Retinal thickness
Choroidal thickness
description Background To evaluate structural changes in retina and choroid in patients with type 2 diabetes (T2D) and their association with diabetic kidney disease (DKD). Methods T2D patients with mild or no diabetic retinopathy (DR) were followed for 3 years using structural SS-OCT and OCT angiography (OCT-A) taken every 6 months. Parameters were compared longitudinally and according to the DKD status on baseline. Results One hundred and sixty eyes from 80 patients were followed for 3 years, 72 with no DKD (nDKD) at baseline and 88 with DKD. Trend analysis of T2D showed signifcant thinning in GCL+and circumpapillary retinal fber neural layer (cRFNL), choroid, and decreased vascular density (VD) in superfcial plexus and central choriocapillaris with foveal avascular zone (FAZ) enlargement. Patients with no DKD on baseline presented more signifcant declines in retinal center and choroidal thickness, increased FAZ and loss of nasal and temporal choriocapillaris volume. In addition, the nDKD group had worse glycemic control and renal parameters at the end of the study. Conclusion Our data suggests the potential existence of early and progressive neurovascular damage in the retina and choroid of patients with Type 2 Diabetes (T2D) who have either no or mild Diabetic Retinopathy (DR). The progression of neurovascular damage appears to be correlated with parameters related to glycemic control and renal damage.
publishDate 2024
dc.date.issued.fl_str_mv 2024
dc.date.accessioned.fl_str_mv 2025-03-27T06:41:55Z
dc.type.driver.fl_str_mv Estrangeiro
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dc.identifier.issn.pt_BR.fl_str_mv 1471-2415
dc.identifier.nrb.pt_BR.fl_str_mv 001243868
identifier_str_mv 1471-2415
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url http://hdl.handle.net/10183/289106
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv BMC ophthalmology. London. Vol. 24 (2024), 85, 10 p.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
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