Primary signet-ring cell carcinoma of the urinary bladder ‒ A rare bladder tumor

Aim: Primary Signet Ring Cell Carcinoma (SRCC) of the bladder accounts for only 1%‒4% of all bladder malignancies. To date, few studies have been conducted to investigate the characteristics of SRCC. This study aimed to investigate the clinical features and treatments of SRCC and explore the indepen...

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Autores: Hong, Xin, Wang, Tian, Liu, Qing, Bi, Jianlong, Li, Hui
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:Brasil
Institución:Universidade de São Paulo (USP)
Repositorio:Clinics
Idioma:inglés
OAI Identifier:oai:revistas.usp.br:article/237741
Acceso en línea:https://revistas.usp.br/clinics/article/view/237741
Access Level:acceso abierto
Palabra clave:Primary signet-ring cell carcinoma
Bladder adenocarcinoma
GATA3
Mortality
Independent risk factor
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spelling Primary signet-ring cell carcinoma of the urinary bladder ‒ A rare bladder tumorPrimary signet-ring cell carcinomaBladder adenocarcinomaGATA3MortalityIndependent risk factorAim: Primary Signet Ring Cell Carcinoma (SRCC) of the bladder accounts for only 1%‒4% of all bladder malignancies. To date, few studies have been conducted to investigate the characteristics of SRCC. This study aimed to investigate the clinical features and treatments of SRCC and explore the independent risk factors of survival in SRCC patients. Patients and methods: A retrospective study was conducted on 32 eligible patients. The survival rate was calculated with the Kaplan-Meier method, and the COX proportional hazards model was used to investigate the independent risk factors of prognosis. Results: In the present study, the 1-year and 2-year survival rates of SRCC patients were 53.1% and 9.4%, respectively. The TNM stage, tumor differentiation, and metastasis after treatment were risk factors for the prognosis of SRCC patients (p < 0.05), while surgical treatment, chemotherapy, and positive GATA3 expression were protective for prognosis (p < 0.05). Multivariate analysis showed that GATA3 was an independent protective factor for prognosis (p < 0.05), and T-stage was an independent risk factor (p < 0.05). Conclusions: Primary SRCC of the bladder is highly malignant and has a poor prognosis. Its clinical and imaging findings are usually non-specific. Early radical cystectomy and postoperative adjuvant systemic chemotherapy are helpful to improve the survival rate. T-stage is an independent risk factor for survival, and positive GATA3 expression is protective for primary SRCC of the bladder.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2024-02-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistas.usp.br/clinics/article/view/23774110.1016/Clinics; Vol. 79 (2024); 100500Clinics; v. 79 (2024); 100500Clinics; Vol. 79 (2024); 1005001980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://revistas.usp.br/clinics/article/view/237741/214643Copyright (c) 2024 Clinicsinfo:eu-repo/semantics/openAccessHong, XinWang, TianLiu, QingBi, JianlongLi, Hui2025-06-17T18:45:43Zoai:revistas.usp.br:article/237741Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2025-06-17T18:45:43Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Primary signet-ring cell carcinoma of the urinary bladder ‒ A rare bladder tumor
title Primary signet-ring cell carcinoma of the urinary bladder ‒ A rare bladder tumor
spellingShingle Primary signet-ring cell carcinoma of the urinary bladder ‒ A rare bladder tumor
Hong, Xin
Primary signet-ring cell carcinoma
Bladder adenocarcinoma
GATA3
Mortality
Independent risk factor
title_short Primary signet-ring cell carcinoma of the urinary bladder ‒ A rare bladder tumor
title_full Primary signet-ring cell carcinoma of the urinary bladder ‒ A rare bladder tumor
title_fullStr Primary signet-ring cell carcinoma of the urinary bladder ‒ A rare bladder tumor
title_full_unstemmed Primary signet-ring cell carcinoma of the urinary bladder ‒ A rare bladder tumor
title_sort Primary signet-ring cell carcinoma of the urinary bladder ‒ A rare bladder tumor
dc.creator.none.fl_str_mv Hong, Xin
Wang, Tian
Liu, Qing
Bi, Jianlong
Li, Hui
author Hong, Xin
author_facet Hong, Xin
Wang, Tian
Liu, Qing
Bi, Jianlong
Li, Hui
author_role author
author2 Wang, Tian
Liu, Qing
Bi, Jianlong
Li, Hui
author2_role author
author
author
author
dc.subject.por.fl_str_mv Primary signet-ring cell carcinoma
Bladder adenocarcinoma
GATA3
Mortality
Independent risk factor
topic Primary signet-ring cell carcinoma
Bladder adenocarcinoma
GATA3
Mortality
Independent risk factor
description Aim: Primary Signet Ring Cell Carcinoma (SRCC) of the bladder accounts for only 1%‒4% of all bladder malignancies. To date, few studies have been conducted to investigate the characteristics of SRCC. This study aimed to investigate the clinical features and treatments of SRCC and explore the independent risk factors of survival in SRCC patients. Patients and methods: A retrospective study was conducted on 32 eligible patients. The survival rate was calculated with the Kaplan-Meier method, and the COX proportional hazards model was used to investigate the independent risk factors of prognosis. Results: In the present study, the 1-year and 2-year survival rates of SRCC patients were 53.1% and 9.4%, respectively. The TNM stage, tumor differentiation, and metastasis after treatment were risk factors for the prognosis of SRCC patients (p < 0.05), while surgical treatment, chemotherapy, and positive GATA3 expression were protective for prognosis (p < 0.05). Multivariate analysis showed that GATA3 was an independent protective factor for prognosis (p < 0.05), and T-stage was an independent risk factor (p < 0.05). Conclusions: Primary SRCC of the bladder is highly malignant and has a poor prognosis. Its clinical and imaging findings are usually non-specific. Early radical cystectomy and postoperative adjuvant systemic chemotherapy are helpful to improve the survival rate. T-stage is an independent risk factor for survival, and positive GATA3 expression is protective for primary SRCC of the bladder.
publishDate 2024
dc.date.none.fl_str_mv 2024-02-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistas.usp.br/clinics/article/view/237741
10.1016/
url https://revistas.usp.br/clinics/article/view/237741
identifier_str_mv 10.1016/
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revistas.usp.br/clinics/article/view/237741/214643
dc.rights.driver.fl_str_mv Copyright (c) 2024 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2024 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 79 (2024); 100500
Clinics; v. 79 (2024); 100500
Clinics; Vol. 79 (2024); 100500
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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score 15,301603

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