TNFA-308G>A and IL10-1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection
Background: Genetic changes may induce dysregulated cytokine production and afect the progression of the chronic disease caused by the hepacivirus C (HCV) because the balance of pro- and anti-infammatory cytokines determines the outcome of infection. This study evaluated the TNFA -308G>A and IL10...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | Brasil |
| Institución: | Instituto Evandro Chagas (IEC) |
| Repositorio: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
| Idioma: | inglés |
| OAI Identifier: | oai:patua.iec.gov.br:iec/4472 |
| Acceso en línea: | https://patua.iec.gov.br/handle/iec/4472 |
| Access Level: | acceso abierto |
| Palabra clave: | Hepatite C / virologia Hepacivirus / patogenicidade Polimorfismo Genético Fator de Necrose Tumoral alfa Interferon gama Interleucina-10 Citocinas |
| Sumario: | Background: Genetic changes may induce dysregulated cytokine production and afect the progression of the chronic disease caused by the hepacivirus C (HCV) because the balance of pro- and anti-infammatory cytokines determines the outcome of infection. This study evaluated the TNFA -308G>A and IL10 -1082A>G polymorphisms in the susceptibility and progress of chronic hepatitis C. Method: The study included 101 samples from patients with chronic hepatitis C and 300 samples from healthy donors. Polymorphisms were typed by real-time PCR and were analyzed for associations with histopathological parameters (according to METAVIR classifcation) and HCV viral load. Results: The polymorphic genotype for the TNFA -308G>A variant was not present in the group of patients with chronic hepatitis C and its absence could be associated with protection against HCV infection (p=0.0477). Patients with the polymorphic genotype of the IL10 -1082A>G polymorphism had higher HCV viral load than wild-type patients (p=0.0428). Neither polymorphism was associated with diferent levels of necroinfammatory activity or fbrosis scores. Conclusion: Our results suggest the polymorphic genotype at TNFA -308G>A as protective against chronic HCV infection, and the polymorphic genotype at the IL10 -1082A>G variant associated with higher HCV viral load. Further studies must be performed in order to confrm these associations. |
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