Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study

Purpose: Interictal intervals in pilocarpine-induced chronic epilepsy are characterized by apparent normal electrographic activity and longer sleep periods or drowsiness or both. Sparse information exists concerning the neural network activity during these seizure-free intervals. in our research, al...

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Detalhes bibliográficos
Autores: Scorza, Fulvio Alexandre [UNIFESP], Sanabria, ERG, Calderazzo, Lineu [UNIFESP], Cavalheiro, Esper Abrão [UNIFESP]
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:1998
País:Brasil
Recursos:Universidade Federal de São Paulo (UNIFESP)
Repositório:Repositório Institucional da UNIFESP
Idioma:inglês
OAI Identifier:oai:repositorio.unifesp.br:11600/25961
Acesso em linha:http://dx.doi.org/10.1111/j.1528-1157.1998.tb01288.x
http://repositorio.unifesp.br/handle/11600/25961
Access Level:Acceso aberto
Palavra-chave:interictal
pilocarpine
epilepsy
deoxyglucose
rat
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oai_identifier_str oai:repositorio.unifesp.br:11600/25961
network_acronym_str BR
network_name_str Brasil
repository_id_str
spelling Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative studyinterictalpilocarpineepilepsydeoxyglucoseratPurpose: Interictal intervals in pilocarpine-induced chronic epilepsy are characterized by apparent normal electrographic activity and longer sleep periods or drowsiness or both. Sparse information exists concerning the neural network activity during these seizure-free intervals. in our research, all [C-14]2-deoxy-D-glucose (2DG) autoradiographic technique was used to investigate interictal changes in the metabolism of the epileptic rat brain.Methods: Epileptic mts were monitored by video-EEG for similar to 120 days, with [C-14]2DG injected after a seizure-free interval of greater than or equal to 24 h.Results: Autoradiographic analysis revealed an increase in glucose utilization by several brain regions; the most consistent increase was found in the lateral posterior thalamic nucleus and prerectal region.Conclusions: These findings suggest that the lateral posterior thalamic nucleus and the prerectal region may be involved in cerebral circuits inhibiting epileptic activity during interictal intervals.UNIFESP, EPM, BR-04023900 São Paulo, BrazilUNIFESP, EPM, BR-04023900 São Paulo, BrazilWeb of ScienceLippincott Williams & WilkinsUniversidade Federal de São Paulo (UNIFESP)2016-01-24T12:30:40Z2016-01-24T12:30:40Z1998-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1041-1045http://dx.doi.org/10.1111/j.1528-1157.1998.tb01288.xEpilepsia. Philadelphia: Lippincott Williams & Wilkins, v. 39, n. 10, p. 1041-1045, 1998.10.1111/j.1528-1157.1998.tb01288.x0013-9580http://repositorio.unifesp.br/handle/11600/25961WOS:000076280500002ark:/48912/001300001txvjengEpilepsiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPScorza, Fulvio Alexandre [UNIFESP]Sanabria, ERGCalderazzo, Lineu [UNIFESP]Cavalheiro, Esper Abrão [UNIFESP]2023-02-14T15:23:16Zoai:repositorio.unifesp.br:11600/25961Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-02-14T15:23:16Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study
title Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study
spellingShingle Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study
Scorza, Fulvio Alexandre [UNIFESP]
interictal
pilocarpine
epilepsy
deoxyglucose
rat
title_short Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study
title_full Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study
title_fullStr Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study
title_full_unstemmed Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study
title_sort Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study
dc.creator.none.fl_str_mv Scorza, Fulvio Alexandre [UNIFESP]
Sanabria, ERG
Calderazzo, Lineu [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
author Scorza, Fulvio Alexandre [UNIFESP]
author_facet Scorza, Fulvio Alexandre [UNIFESP]
Sanabria, ERG
Calderazzo, Lineu [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
author_role author
author2 Sanabria, ERG
Calderazzo, Lineu [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.subject.por.fl_str_mv interictal
pilocarpine
epilepsy
deoxyglucose
rat
topic interictal
pilocarpine
epilepsy
deoxyglucose
rat
description Purpose: Interictal intervals in pilocarpine-induced chronic epilepsy are characterized by apparent normal electrographic activity and longer sleep periods or drowsiness or both. Sparse information exists concerning the neural network activity during these seizure-free intervals. in our research, all [C-14]2-deoxy-D-glucose (2DG) autoradiographic technique was used to investigate interictal changes in the metabolism of the epileptic rat brain.Methods: Epileptic mts were monitored by video-EEG for similar to 120 days, with [C-14]2DG injected after a seizure-free interval of greater than or equal to 24 h.Results: Autoradiographic analysis revealed an increase in glucose utilization by several brain regions; the most consistent increase was found in the lateral posterior thalamic nucleus and prerectal region.Conclusions: These findings suggest that the lateral posterior thalamic nucleus and the prerectal region may be involved in cerebral circuits inhibiting epileptic activity during interictal intervals.
publishDate 1998
dc.date.none.fl_str_mv 1998-10-01
2016-01-24T12:30:40Z
2016-01-24T12:30:40Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/j.1528-1157.1998.tb01288.x
Epilepsia. Philadelphia: Lippincott Williams & Wilkins, v. 39, n. 10, p. 1041-1045, 1998.
10.1111/j.1528-1157.1998.tb01288.x
0013-9580
http://repositorio.unifesp.br/handle/11600/25961
WOS:000076280500002
dc.identifier.dark.fl_str_mv ark:/48912/001300001txvj
url http://dx.doi.org/10.1111/j.1528-1157.1998.tb01288.x
http://repositorio.unifesp.br/handle/11600/25961
identifier_str_mv Epilepsia. Philadelphia: Lippincott Williams & Wilkins, v. 39, n. 10, p. 1041-1045, 1998.
10.1111/j.1528-1157.1998.tb01288.x
0013-9580
WOS:000076280500002
ark:/48912/001300001txvj
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Epilepsia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1041-1045
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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score 15,300719

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