Mesoionic compounds with antifungal activity against Fusarium verticillioides

Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil.

Detalles Bibliográficos
Autores: Paiva, Rojane de Oliveira, Kneipp, Lucimar Ferreira, Reis, Camila Moretto dos, Echevarria, Aurea
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Brasil
Institución:Fundação Oswaldo Cruz (FIOCRUZ)
Repositorio:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglés
OAI Identifier:oai:arca.fiocruz.br:icict/11496
Acceso en línea:https://arca.fiocruz.br/handle/icict/11496
Access Level:acceso abierto
Palabra clave:Mycotoxigenic fungi
Mycotoxicology
Mesoionic
Antifungal activity
Ergosterol
Micotoxinas
Antifúngicos
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dc.title.none.fl_str_mv Mesoionic compounds with antifungal activity against Fusarium verticillioides
title Mesoionic compounds with antifungal activity against Fusarium verticillioides
spellingShingle Mesoionic compounds with antifungal activity against Fusarium verticillioides
Paiva, Rojane de Oliveira
Mycotoxigenic fungi
Mycotoxicology
Mesoionic
Antifungal activity
Ergosterol
Ergosterol
Micotoxinas
Antifúngicos
title_short Mesoionic compounds with antifungal activity against Fusarium verticillioides
title_full Mesoionic compounds with antifungal activity against Fusarium verticillioides
title_fullStr Mesoionic compounds with antifungal activity against Fusarium verticillioides
title_full_unstemmed Mesoionic compounds with antifungal activity against Fusarium verticillioides
title_sort Mesoionic compounds with antifungal activity against Fusarium verticillioides
dc.creator.none.fl_str_mv Paiva, Rojane de Oliveira
Kneipp, Lucimar Ferreira
Reis, Camila Moretto dos
Echevarria, Aurea
author Paiva, Rojane de Oliveira
author_facet Paiva, Rojane de Oliveira
Kneipp, Lucimar Ferreira
Reis, Camila Moretto dos
Echevarria, Aurea
author_role author
author2 Kneipp, Lucimar Ferreira
Reis, Camila Moretto dos
Echevarria, Aurea
author2_role author
author
author
dc.subject.en.none.fl_str_mv Mycotoxigenic fungi
Mycotoxicology
Mesoionic
Antifungal activity
Ergosterol
topic Mycotoxigenic fungi
Mycotoxicology
Mesoionic
Antifungal activity
Ergosterol
Ergosterol
Micotoxinas
Antifúngicos
dc.subject.decs.none.fl_str_mv Ergosterol
Micotoxinas
Antifúngicos
description Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-08-19T13:49:22Z
dc.date.available.fl_str_mv 2015-08-19T13:49:22Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PAIVA, Rojane de Oliveira: et al. Mesoionic compounds with antifungal activity against Fusarium verticillioides. BMC Microbiology, v.15:11, 8p, 2015.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/11496
dc.identifier.issn.none.fl_str_mv 1471-2180
dc.identifier.doi.none.fl_str_mv 10.1186/s12866-015-0340-9
identifier_str_mv PAIVA, Rojane de Oliveira: et al. Mesoionic compounds with antifungal activity against Fusarium verticillioides. BMC Microbiology, v.15:11, 8p, 2015.
1471-2180
10.1186/s12866-015-0340-9
url https://arca.fiocruz.br/handle/icict/11496
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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spelling 2015-08-19T13:49:22Z2015-08-19T13:49:22Z2015PAIVA, Rojane de Oliveira: et al. Mesoionic compounds with antifungal activity against Fusarium verticillioides. BMC Microbiology, v.15:11, 8p, 2015.1471-2180https://arca.fiocruz.br/handle/icict/1149610.1186/s12866-015-0340-9engBioMed CentralMesoionic compounds with antifungal activity against Fusarium verticillioidesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Taxonomia Bioquímica e Bioprospecção de Fungos. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Ciências Exatas. Departamento de Química. Seropédica, RJ, Brasil.Background: Fungi contaminate the food of humans and animals, are a risk to health, and can cause financial losses. In this work, the antifungal activities of 16 mesoionic compounds (MI 1–16) were evaluated against mycotoxigenic fungi, including Aspergillus spp., Fusarium verticillioides and Penicillium citrinum. Furthermore, the decreased ergosterol in the total lipid content of Fusarium verticillioides was investigated. Results: F. verticillioides was the most sensitive fungus to the mesoionic compounds. Among the evaluated compounds, MI-11 and MI-16 presented higher antifungal effects against F. verticillioides, with MIC values of 7.8 μg/ml, and MI-2 and MI-3 followed, with MICs of 15.6 μg/ml. The most active compounds were those with heterocyclic ring phenyl groups substituted by electron donor moieties (MI-11 and MI-16). Among some compounds with higher activity (MI-2, MI-11 and MI-16), decreased ergosterol content in the total lipid fraction of F. verticillioides was demonstrated. MI-2 reduced the ergosterol content approximately 40% and 80% at concentrations of 7.8 μg/ml and 15.6 μg/ml, respectively, and MI-11 and MI-16 decreased the content by 30% and 50%, respectively, when at a concentration of 7.8 μg/ml. Conclusion: These findings indicate that mesoionic compounds have significant antifungal activity against F. verticillioides.Mycotoxigenic fungiMycotoxicologyMesoionicAntifungal activityErgosterolErgosterolMicotoxinasAntifúngicosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZPaiva, Rojane de OliveiraKneipp, Lucimar FerreiraReis, Camila Moretto dosEchevarria, AureaLICENSElicense.txttext/plain1914https://arca.fiocruz.br/bitstreams/3053e98e-061f-457e-942b-2eab771b4b85/download7d48279ffeed55da8dfe2f8e81f3b81fMD51falseAnonymousREADORIGINALrojane_paiva_etal_IOC_2015.pdfapplication/pdf631223https://arca.fiocruz.br/bitstreams/dd545504-f9c2-4d88-9ae3-b9ce0ec97dda/downloadf314e4b6c94c272cb5ffd3cc30ffb3e3MD52trueAnonymousREADTEXTrojane_paiva_etal_IOC_2015.pdf.txtrojane_paiva_etal_IOC_2015.pdf.txtExtracted texttext/plain35650https://arca.fiocruz.br/bitstreams/4e479b73-3aaf-49da-b955-248029bccde1/download2b9bcd36bc2f82fde038ec7ea8a38f8aMD59falseAnonymousREADTHUMBNAILrojane_paiva_etal_IOC_2015.pdf.jpgrojane_paiva_etal_IOC_2015.pdf.jpgGenerated Thumbnailimage/jpeg42685https://arca.fiocruz.br/bitstreams/6d1f54c2-cef4-4eea-9a0e-2db899ec74e4/download9bc5d674f3e6336e1a23776a4201f18dMD510falseAnonymousREADicict/114962025-12-11 08:17:51.087open.accessoai:arca.fiocruz.br:icict/11496https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-12-11T11:17:51Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
score 15.301603

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