p38MAPK plays a pivotal role in the development of acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) is a life-threatening illness characterized by a complex pathophysiology, involving not only the respiratory system but also nonpulmonary distal organs. Although advances in the management of ARDS have led to a distinct improvement in ARDS-related mortality...
| Autores: | , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2019 |
| País: | Brasil |
| Recursos: | Universidade de São Paulo (USP) |
| Repositório: | Clinics |
| Idioma: | inglês |
| OAI Identifier: | oai:revistas.usp.br:article/161181 |
| Acesso em linha: | https://www.revistas.usp.br/clinics/article/view/161181 |
| Access Level: | Acceso aberto |
| Palavra-chave: | ARDS p38MAPK Pathophysiology |
| Resumo: | Acute respiratory distress syndrome (ARDS) is a life-threatening illness characterized by a complex pathophysiology, involving not only the respiratory system but also nonpulmonary distal organs. Although advances in the management of ARDS have led to a distinct improvement in ARDS-related mortality, ARDS is still a lifethreatening respiratory condition with long-term consequences. A better understanding of the pathophysiology of this condition will allow us to create a personalized treatment strategy for improving clinical outcomes. In this article, we present a general overview p38 mitogen-activated protein kinase (p38MAPK) and recent advances in understanding its functions. We consider the potential of the pharmacological targeting of p38MAPK pathways to treat ARDS. |
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