Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats

The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (two kidney one clip

Bibliographic Details
Authors: Pijacka, Wioletta, McBryde, Fiona D., Marvar, Paul J., Lincevicius, Gisele S. [UNIFESP], Abdala, Ana Paula Lima [UNIFESP], Woodward, Lavinia, Li, Dan, Paterson, David J., Paton, Julian F. R.
Format: article
Status:Published version
Publication Date:2016
Country:Brasil
Institution:Universidade Federal de São Paulo (UNIFESP)
Repository:Repositório Institucional da UNIFESP
Language:English
OAI Identifier:oai:repositorio.unifesp.br:11600/56846
Online Access:http://dx.doi.org/10.1113/JP272708
https://repositorio.unifesp.br/handle/11600/56846
Access Level:Open access
Keyword:carotid sinus denervation
chemoreceptor reflex
renovascular hypertension
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spelling Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar ratscarotid sinus denervationchemoreceptor reflexrenovascular hypertensionThe peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (two kidney one clip2K1C) rats. We have previously shown that carotid sinus nerve denervation (CSD) reduces arterial blood pressure (ABP) in SHR. In the present study, we show that CSD ameliorates 2K1C hypertension and reveal the potential underlying mechanisms. Adult Wistar rats were instrumented to record ABP via telemetry, and then underwent CSD (n=9) or sham CSD (n=9) 5weeks after renal artery clipping, in comparison with normal Wistar rats (n=5). After 21days, renal function was assessed, and tissue was collected to assess sympathetic postganglionic intracellular calcium transients ([Ca2+](i)) and immune cell infiltrates. Hypertensive 2K1C rats showed a profound elevation in ABP (Wistar: 984mmHg vs. 2K1C: 1478mmHgP<0.001), coupled with impairments in renal function and baroreflex sensitivity, increased neuroinflammatory markers and enhanced [Ca2+](I) in stellate neurons (P<0.05). CSD reduced ABP in 2K1C+CSD rats and prevented the further progressive increase in ABP seen in 2K1C+sham CSD rats, with a between-group difference of 142mmHg by week 3 (P<0.01), which was accompanied by improvements in both baroreflex control and spectral indicators of cardiac sympatho-vagal balance. Furthermore, CSD improved protein and albuminuria, decreased [Ca2+](i) evoked responses from stellate neurons, and also reduced indicators of brainstem inflammation. In summary, CSD in 2K1C rats reduces the hypertensive burden and improves renal function. This may be mediated by improvements in autonomic balance, functional remodelling of post-ganglionic neurons and reduced inflammation. Our results suggest that the peripheral chemoreflex may be considered as a potential therapeutic target for controlling renovascular hypertension.Univ Bristol, Sch Physiol Pharmacol & Neurosci, Biomed Sci, Bristol, Avon, EnglandUniv Auckland, Dept Physiol, Fac Med & Hlth Sci, Auckland, New ZealandGeorge Washington Univ, Sch Med & Hlth Sci, Dept Pharmacol & Physiol, Washington, DC 20052 USAUniv Fed Sao Paulo, Cardiovasc Div, Escola Paulista Med, Dept Physiol, Sao Paulo, BrazilUniv Oxford, Burdon Sanderson Cardiac Sci Ctr, Dept Physiol Anat & Genet, Oxford OX1 2JD, EnglandCardiovascular Division ‐ Department of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, BrazilWeb of ScienceBritish Heart FoundationRoyal SocietyNational Institutes of Health (NIH)European Commission Research Executive Agency Marie Curie International Incoming FellowshipAmerican Heart AssociationBritish Heart Foundation: RG/12/6/29670NIH: 1R01AT008632-01NIH: R00 HL107675-03European Commission Research Executive Agency Marie Curie International Incoming Fellowship: MC-IIF - 276147American Heart Association: 15CSA24340001Wiley2020-07-31T12:47:29Z2020-07-31T12:47:29Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6255-6266http://dx.doi.org/10.1113/JP272708Journal Of Physiology-London. Hoboken, v. 594, n. 21, p. 6255-6266, 2016.10.1113/JP2727080022-3751https://repositorio.unifesp.br/handle/11600/56846WOS:000387084200016ark:/48912/0013000025v50engJournal Of Physiology-LondonHobokeninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPPijacka, WiolettaMcBryde, Fiona D.Marvar, Paul J.Lincevicius, Gisele S. [UNIFESP]Abdala, Ana Paula Lima [UNIFESP]Woodward, LaviniaLi, DanPaterson, David J.Paton, Julian F. R.2022-10-06T11:07:56Zoai:repositorio.unifesp.br:11600/56846Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652022-10-06T11:07:56Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats
title Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats
spellingShingle Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats
Pijacka, Wioletta
carotid sinus denervation
chemoreceptor reflex
renovascular hypertension
title_short Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats
title_full Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats
title_fullStr Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats
title_full_unstemmed Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats
title_sort Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats
dc.creator.none.fl_str_mv Pijacka, Wioletta
McBryde, Fiona D.
Marvar, Paul J.
Lincevicius, Gisele S. [UNIFESP]
Abdala, Ana Paula Lima [UNIFESP]
Woodward, Lavinia
Li, Dan
Paterson, David J.
Paton, Julian F. R.
author Pijacka, Wioletta
author_facet Pijacka, Wioletta
McBryde, Fiona D.
Marvar, Paul J.
Lincevicius, Gisele S. [UNIFESP]
Abdala, Ana Paula Lima [UNIFESP]
Woodward, Lavinia
Li, Dan
Paterson, David J.
Paton, Julian F. R.
author_role author
author2 McBryde, Fiona D.
Marvar, Paul J.
Lincevicius, Gisele S. [UNIFESP]
Abdala, Ana Paula Lima [UNIFESP]
Woodward, Lavinia
Li, Dan
Paterson, David J.
Paton, Julian F. R.
author2_role author
author
author
author
author
author
author
author
dc.subject.por.fl_str_mv carotid sinus denervation
chemoreceptor reflex
renovascular hypertension
topic carotid sinus denervation
chemoreceptor reflex
renovascular hypertension
description The peripheral chemoreflex is known to be hyper-responsive in both spontaneously hypertensive (SHR) and Goldblatt hypertensive (two kidney one clip
publishDate 2016
dc.date.none.fl_str_mv 2016
2020-07-31T12:47:29Z
2020-07-31T12:47:29Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1113/JP272708
Journal Of Physiology-London. Hoboken, v. 594, n. 21, p. 6255-6266, 2016.
10.1113/JP272708
0022-3751
https://repositorio.unifesp.br/handle/11600/56846
WOS:000387084200016
dc.identifier.dark.fl_str_mv ark:/48912/0013000025v50
url http://dx.doi.org/10.1113/JP272708
https://repositorio.unifesp.br/handle/11600/56846
identifier_str_mv Journal Of Physiology-London. Hoboken, v. 594, n. 21, p. 6255-6266, 2016.
10.1113/JP272708
0022-3751
WOS:000387084200016
ark:/48912/0013000025v50
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal Of Physiology-London
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6255-6266
dc.coverage.none.fl_str_mv Hoboken
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1853670541455523840
score 15,298079

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