Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort : comparison with INTERGROWTH

Objective To assess the predictive value of selected growth phenotypes for neonatal morbidity and mortality in preterm infants < 30 weeks and to compare them with INTERGROWTH-21st (IG21). Method Retrospective analysis of data from the Brazilian Neonatal Research Network (BNRN) database for very l...

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Autores: Cardoso, Viviane C., Silveira, Rita de Cássia dos Santos, Carmona, Fabio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:Brasil
Institución:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositorio:Repositório Institucional da UFRGS
Idioma:inglés
OAI Identifier:oai:www.lume.ufrgs.br:10183/283870
Acceso en línea:http://hdl.handle.net/10183/283870
Access Level:acceso abierto
Palabra clave:Nascimento prematuro
Fenótipo
Prognóstico
Recém-nascido de muito baixo peso
Complicações na gravidez
Premature birth
Very low birth weight
Phenotype
Outcome
Predictive values
Network
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spelling 2025-01-25T06:57:48Z20230021-7557http://hdl.handle.net/10183/283870001217380Objective To assess the predictive value of selected growth phenotypes for neonatal morbidity and mortality in preterm infants < 30 weeks and to compare them with INTERGROWTH-21st (IG21). Method Retrospective analysis of data from the Brazilian Neonatal Research Network (BNRN) database for very low birth weight (VLBW) at 20 public tertiary-care university hospitals. Outcome: the composite neonatal morbidity and mortality (CNMM) consisted of in-hospital death, oxygen use at 36 weeks, intraventricular hemorrhage grade 3 or 4, and Bell stage 2 or 3 necrotizing enterocolitis. Selected growth phenotypes: small-for-gestational-age (SGA) defined as being < 3rd (SGA3) or 10th (SGA10) percentiles of BW, and large-for-gestational-age (LGA) as being > 97th percentile of BW. Stunting as being < 3rd percentile of the length and wasting as being < 3rd percentile of BMI. Single and multiple log-binomial regression models were fitted to estimate the relative risks of CNMM, comparing them to IG21. Results 4,072 infants were included. The adjusted relative risks of CNMM associated with selected growth phenotypes were (BNRN/IG21): 1.45 (0.92–2.31)/1.60 (1.27–2.02) for SGA; 0.90 (0.55–1.47)/1.05 (0.55–1.99) for LGA; 1.65 (1.08–2.51)/1.58 (1.28–1.96) for stunting; and 1.48 (1.02–2.17) for wasting. Agreement between the two references was variable. The growth phenotypes had good specificity (>95%) and positive predictive value (70-90%), with poor sensitivity and low negative predictive value. Conclusion The BNRN phenotypes at birth differed markedly from the IG21 standard and showed poor accuracy in predicting adverse neonatal outcomes.application/pdfengJornal de pediatria. Rio de Janeiro. Vol. 99, no. 1 (2023), p. 86-93Nascimento prematuroFenótipoPrognósticoRecém-nascido de muito baixo pesoComplicações na gravidezPremature birthVery low birth weightPhenotypeOutcomePredictive valuesNetworkGrowth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort : comparison with INTERGROWTHinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSCardoso, Viviane C.Silveira, Rita de Cássia dos SantosCarmona, FabioTEXT001217380.pdf.txt001217380.pdf.txtExtracted Texttext/plain35713http://www.lume.ufrgs.br/bitstream/10183/283870/2/001217380.pdf.txtfc993ee27c8aac253298255d9d995b44MD52ORIGINAL001217380.pdfTexto completo (inglês)application/pdf476064http://www.lume.ufrgs.br/bitstream/10183/283870/1/001217380.pdf3a6c24b056a479a50c0caa77649d51b0MD5110183/2838702025-01-26 07:55:26.561651oai:www.lume.ufrgs.br:10183/283870Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2025-01-26T09:55:26Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort : comparison with INTERGROWTH
title Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort : comparison with INTERGROWTH
spellingShingle Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort : comparison with INTERGROWTH
Cardoso, Viviane C.
Nascimento prematuro
Fenótipo
Prognóstico
Recém-nascido de muito baixo peso
Complicações na gravidez
Premature birth
Very low birth weight
Phenotype
Outcome
Predictive values
Network
title_short Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort : comparison with INTERGROWTH
title_full Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort : comparison with INTERGROWTH
title_fullStr Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort : comparison with INTERGROWTH
title_full_unstemmed Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort : comparison with INTERGROWTH
title_sort Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort : comparison with INTERGROWTH
dc.creator.none.fl_str_mv Cardoso, Viviane C.
Silveira, Rita de Cássia dos Santos
Carmona, Fabio
author Cardoso, Viviane C.
author_facet Cardoso, Viviane C.
Silveira, Rita de Cássia dos Santos
Carmona, Fabio
author_role author
author2 Silveira, Rita de Cássia dos Santos
Carmona, Fabio
author2_role author
author
dc.subject.por.fl_str_mv Nascimento prematuro
Fenótipo
Prognóstico
Recém-nascido de muito baixo peso
Complicações na gravidez
topic Nascimento prematuro
Fenótipo
Prognóstico
Recém-nascido de muito baixo peso
Complicações na gravidez
Premature birth
Very low birth weight
Phenotype
Outcome
Predictive values
Network
dc.subject.eng.fl_str_mv Premature birth
Very low birth weight
Phenotype
Outcome
Predictive values
Network
description Objective To assess the predictive value of selected growth phenotypes for neonatal morbidity and mortality in preterm infants < 30 weeks and to compare them with INTERGROWTH-21st (IG21). Method Retrospective analysis of data from the Brazilian Neonatal Research Network (BNRN) database for very low birth weight (VLBW) at 20 public tertiary-care university hospitals. Outcome: the composite neonatal morbidity and mortality (CNMM) consisted of in-hospital death, oxygen use at 36 weeks, intraventricular hemorrhage grade 3 or 4, and Bell stage 2 or 3 necrotizing enterocolitis. Selected growth phenotypes: small-for-gestational-age (SGA) defined as being < 3rd (SGA3) or 10th (SGA10) percentiles of BW, and large-for-gestational-age (LGA) as being > 97th percentile of BW. Stunting as being < 3rd percentile of the length and wasting as being < 3rd percentile of BMI. Single and multiple log-binomial regression models were fitted to estimate the relative risks of CNMM, comparing them to IG21. Results 4,072 infants were included. The adjusted relative risks of CNMM associated with selected growth phenotypes were (BNRN/IG21): 1.45 (0.92–2.31)/1.60 (1.27–2.02) for SGA; 0.90 (0.55–1.47)/1.05 (0.55–1.99) for LGA; 1.65 (1.08–2.51)/1.58 (1.28–1.96) for stunting; and 1.48 (1.02–2.17) for wasting. Agreement between the two references was variable. The growth phenotypes had good specificity (>95%) and positive predictive value (70-90%), with poor sensitivity and low negative predictive value. Conclusion The BNRN phenotypes at birth differed markedly from the IG21 standard and showed poor accuracy in predicting adverse neonatal outcomes.
publishDate 2023
dc.date.issued.fl_str_mv 2023
dc.date.accessioned.fl_str_mv 2025-01-25T06:57:48Z
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dc.identifier.issn.pt_BR.fl_str_mv 0021-7557
dc.identifier.nrb.pt_BR.fl_str_mv 001217380
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Jornal de pediatria. Rio de Janeiro. Vol. 99, no. 1 (2023), p. 86-93
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
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