Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo : case report

We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resi...

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Detalhes bibliográficos
Autores: Vettorato, Rodrigo, Heidrich, Daiane, Gomes, Fernanda Fraga, Ribeiro, Amanda Carvalho, Pagani, Danielle Machado, Timotheo, Carina Alves, Amaro, Tais Guarienti, Vettorato, Gerson, Scroferneker, Maria Lucia
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2018
País:Brasil
Recursos:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositório:Repositório Institucional da UFRGS
Idioma:inglês
OAI Identifier:oai:www.lume.ufrgs.br:10183/172646
Acesso em linha:http://hdl.handle.net/10183/172646
Access Level:Acceso aberto
Palavra-chave:Sporothrix schenckii
Antifúngicos
Esporotricose
Itraconazol
Sporotrichosis
Senso stricto
Itraconazole
Terbinafine
Antifungal susceptibility
Descrição
Resumo:We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months.

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