Strontium-loaded titanium surface promotes the MC3T3-E1 pre-osteoblasts growth and S. aureus adhesion

Addressing the challenges of biomedical implant failures necessitates innovative approaches within biomaterials research. This study introduces a groundbreaking methodology to enhance both osteogenic and antibacterial properties in biomedical implants focusing on strontium properties. Three titanium...

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Detalhes bibliográficos
Autores: Cominotte, Mariana Aline [UNESP], Santana, Luis Carlos Leal, de Foggi, Camila Cristina, Matos, Flavia Gomes [UNESP], Florian, Fernanda [UNESP], de Assis, Marcelo, Vergani, Carlos Eduardo [UNESP], Vaz, Luis Geraldo [UNESP], Longo, Elson, Cirelli, Joni Augusto [UNESP]
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:Brasil
Recursos:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/302910
Acesso em linha:http://dx.doi.org/10.1557/s43578-024-01305-9
https://hdl.handle.net/11449/302910
Access Level:acceso abierto
Palavra-chave:Biofilm
Biomaterial
Osteoblasts
Strontium
Surface chemistry
Titanium
Descrição
Resumo:Addressing the challenges of biomedical implant failures necessitates innovative approaches within biomaterials research. This study introduces a groundbreaking methodology to enhance both osteogenic and antibacterial properties in biomedical implants focusing on strontium properties. Three titanium surfaces—machine-polished (control), alkaline-etched (AES), and strontium-loaded alkaline-etched (Sr-AES) were evaluated. The results highlight the AES and Sr-AES groups exhibit heightened surface free energy and wettability. Sr+ release peaks on days 1 and 3, tapering off later timepoints. The Sr-AES group demonstrates a trend toward increased MC3T3-E1 proliferation at days 10 and 14. Notwithstanding, the AES and Sr-AES groups presented a greater proportion of viable S. aureus compared to the control. This study unveils Sr-AES as a novel titanium surface modification, showing potential in fostering MC3T3-E1 pre-osteoblast cell growth despite lacking antibiofilm effects. These findings bear significant implications for the progression of biomedical implants, urging sustained innovation in materials design for enhanced biological compatibility. Graphical abstract: (Figure presented.).

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