Evaluating the effects of vanadyl sulfate on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2
Vanadyl sulfate (VS) is an ingredient in some food supplements and experimental drugs. This study was designed to assay the effects of VS on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2. 30 male Wistar rats were divided into three equal groups as follo...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | Brasil |
| Institución: | Universidade de São Paulo (USP) |
| Repositorio: | Brazilian Journal of Pharmaceutical Sciences |
| Idioma: | inglés |
| OAI Identifier: | oai:revistas.usp.br:article/181914 |
| Acceso en línea: | https://www.revistas.usp.br/bjps/article/view/181914 |
| Access Level: | acceso abierto |
| Palabra clave: | Vanadyl Sulfate, IL-1, IL-10 Oxidative Stress Inflammations |
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Evaluating the effects of vanadyl sulfate on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2Vanadyl Sulfate, IL-1, IL-10Oxidative StressInflammationsVanadyl sulfate (VS) is an ingredient in some food supplements and experimental drugs. This study was designed to assay the effects of VS on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2. 30 male Wistar rats were divided into three equal groups as follow: non-diabetics, non-treated diabetics and VS-treated diabetics. Diabetes type 2 has been induced through high fat diet and fructose in the animals. Diabetic rats were treated with 25 mg/kgBW of VS in water for 12 weeks. At the end of study, glucose and insulin were measured using commercially available kits in serum and biomarkers of oxidative stress and inflammation in renal homogenates of animals were measured by related methods. Compared to controls, glucose and insulin were increased significantly in non-treated diabetic rats (p-value <0.05) that showed the induction of diabetes type 2 in rats. The results showed that in VS-treated diabetic rats compared to the non-treated diabetic group, vanadyl sulfate significantly reduced the glucose and insulin secretion and changed renal inflammatory and oxidative markers, except protein carbonyl so that we couldn’t find any significant changes. Our study showed that vanadyl supplementation had positive effects on oxidative stress and inflammation biomarkers in kidney of diabetic rats.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2020-12-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/18191410.1590/s2175-97902019000318586Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18586Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18586Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e185862175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/181914/168751Copyright (c) 2021 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFereshteh, Bahmani Ali-Reza, Afsharipour Nastaran, Manteghie Mohsen, Taghizadeh Mehdii, Mirhashemi Seyyed 2021-06-12T19:46:54Zoai:revistas.usp.br:article/181914Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-06-12T19:46:54Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
| dc.title.none.fl_str_mv |
Evaluating the effects of vanadyl sulfate on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2 |
| title |
Evaluating the effects of vanadyl sulfate on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2 |
| spellingShingle |
Evaluating the effects of vanadyl sulfate on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2 Fereshteh, Bahmani Vanadyl Sulfate, IL-1, IL-10 Oxidative Stress Inflammations |
| title_short |
Evaluating the effects of vanadyl sulfate on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2 |
| title_full |
Evaluating the effects of vanadyl sulfate on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2 |
| title_fullStr |
Evaluating the effects of vanadyl sulfate on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2 |
| title_full_unstemmed |
Evaluating the effects of vanadyl sulfate on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2 |
| title_sort |
Evaluating the effects of vanadyl sulfate on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2 |
| dc.creator.none.fl_str_mv |
Fereshteh, Bahmani Ali-Reza, Afsharipour Nastaran, Manteghie Mohsen, Taghizadeh Mehdii, Mirhashemi Seyyed |
| author |
Fereshteh, Bahmani |
| author_facet |
Fereshteh, Bahmani Ali-Reza, Afsharipour Nastaran, Manteghie Mohsen, Taghizadeh Mehdii, Mirhashemi Seyyed |
| author_role |
author |
| author2 |
Ali-Reza, Afsharipour Nastaran, Manteghie Mohsen, Taghizadeh Mehdii, Mirhashemi Seyyed |
| author2_role |
author author author author |
| dc.subject.por.fl_str_mv |
Vanadyl Sulfate, IL-1, IL-10 Oxidative Stress Inflammations |
| topic |
Vanadyl Sulfate, IL-1, IL-10 Oxidative Stress Inflammations |
| description |
Vanadyl sulfate (VS) is an ingredient in some food supplements and experimental drugs. This study was designed to assay the effects of VS on biomarkers of oxidative stress and inflammation in renal tissue of rats with diabetes type 2. 30 male Wistar rats were divided into three equal groups as follow: non-diabetics, non-treated diabetics and VS-treated diabetics. Diabetes type 2 has been induced through high fat diet and fructose in the animals. Diabetic rats were treated with 25 mg/kgBW of VS in water for 12 weeks. At the end of study, glucose and insulin were measured using commercially available kits in serum and biomarkers of oxidative stress and inflammation in renal homogenates of animals were measured by related methods. Compared to controls, glucose and insulin were increased significantly in non-treated diabetic rats (p-value <0.05) that showed the induction of diabetes type 2 in rats. The results showed that in VS-treated diabetic rats compared to the non-treated diabetic group, vanadyl sulfate significantly reduced the glucose and insulin secretion and changed renal inflammatory and oxidative markers, except protein carbonyl so that we couldn’t find any significant changes. Our study showed that vanadyl supplementation had positive effects on oxidative stress and inflammation biomarkers in kidney of diabetic rats. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-12-09 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/181914 10.1590/s2175-97902019000318586 |
| url |
https://www.revistas.usp.br/bjps/article/view/181914 |
| identifier_str_mv |
10.1590/s2175-97902019000318586 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/181914/168751 |
| dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Copyright (c) 2021 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
| publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
| dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18586 Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18586 Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18586 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
| instname_str |
Universidade de São Paulo (USP) |
| instacron_str |
USP |
| institution |
USP |
| reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
| collection |
Brazilian Journal of Pharmaceutical Sciences |
| repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
| repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
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1853675623791198208 |
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15.301629 |