People living with HIV on ART have accurate perception of lipodystrophy signs : a cross sectional study

Background: The prevalence of lipodystrophy ranges from 31 to 65%, depending on the criteria adopted for diagnosis. The usual methods applied in the diagnosis vary from self-perception, medical examination, skinfolds measurements, or even imaging assessment for confirmation of fat distribution chang...

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Autores: Alencastro, Paulo Ricardo de, Barcellos, Nêmora Tregnago, Wolff, Fernando Herz, Ikeda, Maria Letícia Rodrigues, Trevisol, Fabiana Schuelter, Brandao, Ajacio Bandeira de Mello, Fuchs, Sandra Cristina Pereira Costa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Brasil
Institución:Universidade Federal do Rio Grande do Sul (UFRGS)
Repositorio:Repositório Institucional da UFRGS
Idioma:inglés
OAI Identifier:oai:www.lume.ufrgs.br:10183/169176
Acceso en línea:http://hdl.handle.net/10183/169176
Access Level:acceso abierto
Palabra clave:Fármacos anti-HIV
Lipodistrofia
Infecções por HIV
Feminino
Masculino
HIV
AIDS
Lipodystrophy
Lipohypertrophy
Lipoatrophy
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spelling 2017-10-06T02:30:17Z20171756-0500http://hdl.handle.net/10183/169176001048782Background: The prevalence of lipodystrophy ranges from 31 to 65%, depending on the criteria adopted for diagnosis. The usual methods applied in the diagnosis vary from self-perception, medical examination, skinfolds measurements, or even imaging assessment for confirmation of fat distribution changes. Although several methods have been developed, there is no gold standard for characterization of LA and LH, or mixed forms. This study aimed to compare self-reported signs of lipodystrophy with objective measures by skinfolds and circumferences, and to evaluate the prevalence of lipoatrophy (LA) and lipohypertrophy (LH) among subjects living with HIV/AIDS on ART. Methods: A cross-sectional study enrolled participants living with HIV/AIDS receiving ART, aged 18 years or older from an outpatient health care center, in Southern Brazil. Self-reported body fat enlargement in the abdomen, chest or breasts, and dorsocervical fat pad were used to determine LH, while LA was identified by self-reported fat wasting of the face, neck, legs, arms or buttocks. Measurements were obtained with a scientific caliper for infraorbital, buccal, and submandibular skinfolds, and using an inelastic tape to measure circumferences of waist, hip, neck, and arm. LH and LA were established by the presence of at least one self-reported sign. Results: Comparisons of self-reported signs with objective measurements for men and women were carried out in 815 participants on ART, out of 1240 participants with HIV infection. Self-report of decreased facial fat and sunken cheeks was associated with lower infraorbital, buccal, and submandibular skinfolds. Participants who reported buffalo hump had, on average, greater neck circumference, as well as those who have increased waist circumference also reported abdominal enlargement, but no buttock wasting. Men were most commonly affected by lipoatrophy (73 vs. 53%; P < 0.001), and women by lipohypertrophy (79 vs. 56%; P < 0.001). Conclusion: In conclusion, self-reported signs of lipodystrophy and lipoatrophy are prevalent, differ by gender, and are associated with objective measurements in people living with HIV/AIDS.application/pdfengBMC research notes. London. Vol. 10 (2017), 40, 8 p.Fármacos anti-HIVLipodistrofiaInfecções por HIVFemininoMasculinoHIVAIDSLipodystrophyLipohypertrophyLipoatrophyPeople living with HIV on ART have accurate perception of lipodystrophy signs : a cross sectional studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSAlencastro, Paulo Ricardo deBarcellos, Nêmora TregnagoWolff, Fernando HerzIkeda, Maria Letícia RodriguesTrevisol, Fabiana SchuelterBrandao, Ajacio Bandeira de MelloFuchs, Sandra Cristina Pereira CostaORIGINAL001048782.pdf001048782.pdfTexto completo (inglês)application/pdf862002http://www.lume.ufrgs.br/bitstream/10183/169176/1/001048782.pdf6fe5ab1d649bfc42beb248eca20704abMD51TEXT001048782.pdf.txt001048782.pdf.txtExtracted Texttext/plain31868http://www.lume.ufrgs.br/bitstream/10183/169176/2/001048782.pdf.txt030b73ac7c8a573c510eacedb035d027MD52THUMBNAIL001048782.pdf.jpg001048782.pdf.jpgGenerated Thumbnailimage/jpeg1983http://www.lume.ufrgs.br/bitstream/10183/169176/3/001048782.pdf.jpgb9d533a7b828ac97dd14e2d32ff19c75MD5310183/1691762023-11-24 04:25:28.470241oai:www.lume.ufrgs.br:10183/169176Repositório InstitucionalPUBhttps://lume.ufrgs.br/oai/requestlume@ufrgs.bropendoar:2023-11-24T06:25:28Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv People living with HIV on ART have accurate perception of lipodystrophy signs : a cross sectional study
title People living with HIV on ART have accurate perception of lipodystrophy signs : a cross sectional study
spellingShingle People living with HIV on ART have accurate perception of lipodystrophy signs : a cross sectional study
Alencastro, Paulo Ricardo de
Fármacos anti-HIV
Lipodistrofia
Infecções por HIV
Feminino
Masculino
HIV
AIDS
Lipodystrophy
Lipohypertrophy
Lipoatrophy
title_short People living with HIV on ART have accurate perception of lipodystrophy signs : a cross sectional study
title_full People living with HIV on ART have accurate perception of lipodystrophy signs : a cross sectional study
title_fullStr People living with HIV on ART have accurate perception of lipodystrophy signs : a cross sectional study
title_full_unstemmed People living with HIV on ART have accurate perception of lipodystrophy signs : a cross sectional study
title_sort People living with HIV on ART have accurate perception of lipodystrophy signs : a cross sectional study
dc.creator.none.fl_str_mv Alencastro, Paulo Ricardo de
Barcellos, Nêmora Tregnago
Wolff, Fernando Herz
Ikeda, Maria Letícia Rodrigues
Trevisol, Fabiana Schuelter
Brandao, Ajacio Bandeira de Mello
Fuchs, Sandra Cristina Pereira Costa
author Alencastro, Paulo Ricardo de
author_facet Alencastro, Paulo Ricardo de
Barcellos, Nêmora Tregnago
Wolff, Fernando Herz
Ikeda, Maria Letícia Rodrigues
Trevisol, Fabiana Schuelter
Brandao, Ajacio Bandeira de Mello
Fuchs, Sandra Cristina Pereira Costa
author_role author
author2 Barcellos, Nêmora Tregnago
Wolff, Fernando Herz
Ikeda, Maria Letícia Rodrigues
Trevisol, Fabiana Schuelter
Brandao, Ajacio Bandeira de Mello
Fuchs, Sandra Cristina Pereira Costa
author2_role author
author
author
author
author
author
dc.subject.por.fl_str_mv Fármacos anti-HIV
Lipodistrofia
Infecções por HIV
Feminino
Masculino
topic Fármacos anti-HIV
Lipodistrofia
Infecções por HIV
Feminino
Masculino
HIV
AIDS
Lipodystrophy
Lipohypertrophy
Lipoatrophy
dc.subject.eng.fl_str_mv HIV
AIDS
Lipodystrophy
Lipohypertrophy
Lipoatrophy
description Background: The prevalence of lipodystrophy ranges from 31 to 65%, depending on the criteria adopted for diagnosis. The usual methods applied in the diagnosis vary from self-perception, medical examination, skinfolds measurements, or even imaging assessment for confirmation of fat distribution changes. Although several methods have been developed, there is no gold standard for characterization of LA and LH, or mixed forms. This study aimed to compare self-reported signs of lipodystrophy with objective measures by skinfolds and circumferences, and to evaluate the prevalence of lipoatrophy (LA) and lipohypertrophy (LH) among subjects living with HIV/AIDS on ART. Methods: A cross-sectional study enrolled participants living with HIV/AIDS receiving ART, aged 18 years or older from an outpatient health care center, in Southern Brazil. Self-reported body fat enlargement in the abdomen, chest or breasts, and dorsocervical fat pad were used to determine LH, while LA was identified by self-reported fat wasting of the face, neck, legs, arms or buttocks. Measurements were obtained with a scientific caliper for infraorbital, buccal, and submandibular skinfolds, and using an inelastic tape to measure circumferences of waist, hip, neck, and arm. LH and LA were established by the presence of at least one self-reported sign. Results: Comparisons of self-reported signs with objective measurements for men and women were carried out in 815 participants on ART, out of 1240 participants with HIV infection. Self-report of decreased facial fat and sunken cheeks was associated with lower infraorbital, buccal, and submandibular skinfolds. Participants who reported buffalo hump had, on average, greater neck circumference, as well as those who have increased waist circumference also reported abdominal enlargement, but no buttock wasting. Men were most commonly affected by lipoatrophy (73 vs. 53%; P < 0.001), and women by lipohypertrophy (79 vs. 56%; P < 0.001). Conclusion: In conclusion, self-reported signs of lipodystrophy and lipoatrophy are prevalent, differ by gender, and are associated with objective measurements in people living with HIV/AIDS.
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-10-06T02:30:17Z
dc.date.issued.fl_str_mv 2017
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dc.identifier.issn.pt_BR.fl_str_mv 1756-0500
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dc.relation.ispartof.pt_BR.fl_str_mv BMC research notes. London. Vol. 10 (2017), 40, 8 p.
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