Libidibia ferrea presents antiproliferative, apoptotic and antioxidant effects in a colorectal cancer cell line

Colorectal cancer is noted for being one of the most frequent of tumors, with expressive morbidity and mortality rates. In new drug discovery, plants stand out as a source capable of yielding safe and highefficiency products. Well known in Brazilian popular medicine, Libidibia ferrea (Mart. Ex Tul.)...

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Detalles Bibliográficos
Autores: Araújo, Aurigena Antunes de, Guerra, Andreza Conceição Véras de Aguiar, Soares, Luiz Alberto Lira, Ferreira, Magda Rhayanny Assunção, Rocha, Hugo Alexandre de Oliveira, Medeirose, Juliana Silva de, Cavalcante, Rômulo dos Santos, Araújo Júnior, Raimundo Fernandes de
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Brasil
Institución:Universidade Federal do Rio Grande do Norte (UFRN)
Repositorio:Repositório Institucional da UFRN
Idioma:portugués
OAI Identifier:oai:repositorio.ufrn.br:123456789/30221
Acceso en línea:https://repositorio.ufrn.br/handle/123456789/30221
Access Level:acceso abierto
Palabra clave:Libidibia ferrea
Colorectal cancer
Apoptosis
Antioxidant
Descripción
Sumario:Colorectal cancer is noted for being one of the most frequent of tumors, with expressive morbidity and mortality rates. In new drug discovery, plants stand out as a source capable of yielding safe and highefficiency products. Well known in Brazilian popular medicine, Libidibia ferrea (Mart. Ex Tul.) L.P. Queiroz var. ferrea (better known as “ironwood” or “jucá”), has been used to treat a wide spectrum of conditions and to prevent cancer. Using methodologies that involved flow cytometry, spectrophotometry and RT-qPCR assays, crude extracts of the fruits of L. ferrea (20T, 40T, 60T and 80T) were evaluated at 24 h and/or 48 h for: their ability to inhibit cell proliferation; induce apoptosis through Bcl-2, caspase-3 and Apaf-1; their antioxidant activity and effects on important targets related to cell proliferation (EGFR and AKT) in the HT-29 human colorectal cancer lineage. The results revealed high antiproliferative potential as compared to the controls, induction of apoptosis through the intrinsic pathway, and probable tumor inhibition activity under the mediation of important targets in tumorigenesis. In addition, L. ferrea revealed antioxidant, lipid peroxidation and chemoprotective effects in healthy cells. Thus, L. ferrea derivatives have important anticancer effects, and may be considered promising candidate for colorectal cancer therapy.

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