Exercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosis

Melo, Brunno Lemes de [UNIFESP]; Vieira, Stella de Souza [UNIFESP]; Antonio, Ednei Luiz [UNIFESP]; Santos, Luis Felipe Neves dos [UNIFESP]; Portes, Leslie Andrews [UNIFESP]; Feliciano, Regiane S.; de Oliveira, Helenita A.; Silva, Jose A., Jr.; de Carvalho, Paulo de Tarso C.; Tucci, Paulo José Ferreira [UNIFESP]; Serra, Andrey Jorge [UNIFESP]

Exercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosis

Introduction: Pulmonary arterial stenosis (PAS) is a congenital defect that causes outflow tract obstruction of the right ventricle (RV. Currently, negative issues are reported in the PAS management: not all patients may be eligible to surgeries

Detalles Bibliográficos
Autores:	Melo, Brunno Lemes de [UNIFESP], Vieira, Stella de Souza [UNIFESP], Antonio, Ednei Luiz [UNIFESP], Santos, Luis Felipe Neves dos [UNIFESP], Portes, Leslie Andrews [UNIFESP], Feliciano, Regiane S., de Oliveira, Helenita A., Silva, Jose A., Jr., de Carvalho, Paulo de Tarso C., Tucci, Paulo José Ferreira [UNIFESP], Serra, Andrey Jorge [UNIFESP]
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2016
País:	Brasil
Institución:	Universidade Federal de São Paulo (UNIFESP)
Repositorio:	Repositório Institucional da UNIFESP
Idioma:	inglés
OAI Identifier:	oai:repositorio.unifesp.br:11600/56559
Acceso en línea:	http://dx.doi.org/10.3389/fphys.2016.00541 https://repositorio.unifesp.br/handle/11600/56559
Access Level:	acceso abierto
Palabra clave:	artery pulmonary stenosis cardiac hypertrophy cardiac remodeling exercise training right ventricular hypertrophy

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network_name_str	Brasil
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spelling	Exercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosisartery pulmonary stenosiscardiac hypertrophycardiac remodelingexercise trainingright ventricular hypertrophyIntroduction: Pulmonary arterial stenosis (PAS) is a congenital defect that causes outflow tract obstruction of the right ventricle (RV. Currently, negative issues are reported in the PAS management: not all patients may be eligible to surgeriesthere is often the need for another surgery during passage to adulthoodpatients with mild stenosis may have later cardiac adverse repercussions. Thus, the search for approaches to counteract the long-term PAS effects showed to be a current target. At the study herein, we evaluated the cardioprotective role of exercise training in rats submitted to PAS for 9 weeks. Methods and Results: Exercise resulted in improved physical fitness and systolic RV function. Exercise also blunted concentric cavity changes, diastolic dysfunction, and fibrosis induced by PAS. Exercise additional benefits were also reported in a pro-survival signal, in which there were increased Akt(1) activity and normalized myocardial apoptosis. These findings were accompanied by microRNA-1 downregulation and microRNA-21 upregulation. Moreover, exercise was associated with a higher myocardial abundance of the sarcomeric protein alpha-MHC and proteins that modulate calcium handling ryanodine receptor and Serca 2, supporting the potential role of exercise in improving myocardial performance. Conclusion: Our results represent the first demonstration that exercise can attenuate the RV remodeling in an experimental PAS. The cardioprotective effects were associated with positive modulation of RV function, survival signaling pathway, apoptosis, and proteins involved in the regulation of myocardial contractility.Univ Fed Sao Paulo, Cardiac Physiol Lab, Sao Paulo, BrazilNove de Julho Univ, Biophoton Lab, Sao Paulo, BrazilCardiac Physiology Laboratory, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 09-54225/8FAPESP: 2015/11028-9Frontiers Media Sa2020-07-31T12:47:04Z2020-07-31T12:47:04Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.3389/fphys.2016.00541Frontiers In Physiology. Lausanne, v. 7, p. -, 2016.10.3389/fphys.2016.00541WOS000389156800001.pdf1664-042Xhttps://repositorio.unifesp.br/handle/11600/56559WOS:000389156800001ark:/48912/001300002cr91engFrontiers In PhysiologyLausanneinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPMelo, Brunno Lemes de [UNIFESP]Vieira, Stella de Souza [UNIFESP]Antonio, Ednei Luiz [UNIFESP]Santos, Luis Felipe Neves dos [UNIFESP]Portes, Leslie Andrews [UNIFESP]Feliciano, Regiane S.de Oliveira, Helenita A.Silva, Jose A., Jr.de Carvalho, Paulo de Tarso C.Tucci, Paulo José Ferreira [UNIFESP]Serra, Andrey Jorge [UNIFESP]2024-08-11T11:58:09Zoai:repositorio.unifesp.br:11600/56559Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-11T11:58:09Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv	Exercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosis
title	Exercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosis
spellingShingle	Exercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosis Melo, Brunno Lemes de [UNIFESP] artery pulmonary stenosis cardiac hypertrophy cardiac remodeling exercise training right ventricular hypertrophy
title_short	Exercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosis
title_full	Exercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosis
title_fullStr	Exercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosis
title_full_unstemmed	Exercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosis
title_sort	Exercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosis
dc.creator.none.fl_str_mv	Melo, Brunno Lemes de [UNIFESP] Vieira, Stella de Souza [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Santos, Luis Felipe Neves dos [UNIFESP] Portes, Leslie Andrews [UNIFESP] Feliciano, Regiane S. de Oliveira, Helenita A. Silva, Jose A., Jr. de Carvalho, Paulo de Tarso C. Tucci, Paulo José Ferreira [UNIFESP] Serra, Andrey Jorge [UNIFESP]
author	Melo, Brunno Lemes de [UNIFESP]
author_facet	Melo, Brunno Lemes de [UNIFESP] Vieira, Stella de Souza [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Santos, Luis Felipe Neves dos [UNIFESP] Portes, Leslie Andrews [UNIFESP] Feliciano, Regiane S. de Oliveira, Helenita A. Silva, Jose A., Jr. de Carvalho, Paulo de Tarso C. Tucci, Paulo José Ferreira [UNIFESP] Serra, Andrey Jorge [UNIFESP]
author_role	author
author2	Vieira, Stella de Souza [UNIFESP] Antonio, Ednei Luiz [UNIFESP] Santos, Luis Felipe Neves dos [UNIFESP] Portes, Leslie Andrews [UNIFESP] Feliciano, Regiane S. de Oliveira, Helenita A. Silva, Jose A., Jr. de Carvalho, Paulo de Tarso C. Tucci, Paulo José Ferreira [UNIFESP] Serra, Andrey Jorge [UNIFESP]
author2_role	author author author author author author author author author author
dc.subject.por.fl_str_mv	artery pulmonary stenosis cardiac hypertrophy cardiac remodeling exercise training right ventricular hypertrophy
topic	artery pulmonary stenosis cardiac hypertrophy cardiac remodeling exercise training right ventricular hypertrophy
description	Introduction: Pulmonary arterial stenosis (PAS) is a congenital defect that causes outflow tract obstruction of the right ventricle (RV. Currently, negative issues are reported in the PAS management: not all patients may be eligible to surgeries
publishDate	2016
dc.date.none.fl_str_mv	2016 2020-07-31T12:47:04Z 2020-07-31T12:47:04Z
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://dx.doi.org/10.3389/fphys.2016.00541 Frontiers In Physiology. Lausanne, v. 7, p. -, 2016. 10.3389/fphys.2016.00541 WOS000389156800001.pdf 1664-042X https://repositorio.unifesp.br/handle/11600/56559 WOS:000389156800001
dc.identifier.dark.fl_str_mv	ark:/48912/001300002cr91
url	http://dx.doi.org/10.3389/fphys.2016.00541 https://repositorio.unifesp.br/handle/11600/56559
identifier_str_mv	Frontiers In Physiology. Lausanne, v. 7, p. -, 2016. 10.3389/fphys.2016.00541 WOS000389156800001.pdf 1664-042X WOS:000389156800001 ark:/48912/001300002cr91
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	Frontiers In Physiology
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	- application/pdf
dc.coverage.none.fl_str_mv	Lausanne
dc.publisher.none.fl_str_mv	Frontiers Media Sa
publisher.none.fl_str_mv	Frontiers Media Sa
dc.source.none.fl_str_mv	reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP
instname_str	Universidade Federal de São Paulo (UNIFESP)
instacron_str	UNIFESP
institution	UNIFESP
reponame_str	Repositório Institucional da UNIFESP
collection	Repositório Institucional da UNIFESP
repository.name.fl_str_mv	Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv	biblioteca.csp@unifesp.br
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score	15,300719

Exercise Training Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Stenosis

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