Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil

Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Rio de Janeiro, RJ, Brasil.

Detalhes bibliográficos
Autores: Oliveira, C. A. Basílio de, Aguiar, G. R., Baldanza, M. S., Barth, Ortrud Monika, Eyer-Silva, W. A., Paes, M. V.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2005
País:Brasil
Recursos:Fundação Oswaldo Cruz (FIOCRUZ)
Repositorio:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglés
OAI Identifier:oai:arca.fiocruz.br:icict/37571
Acesso em linha:https://arca.fiocruz.br/handle/icict/37571
Access Level:acceso abierto
Palavra-chave:Sorotipo 3 do vírus da dengue
Febre de Dengue hemorrágica
Imunoperoxidase
Dengue virus serotype 3
Dengue hemorrhagic fever
Immunoperoxidase
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dc.title.none.fl_str_mv Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil
title Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil
spellingShingle Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil
Oliveira, C. A. Basílio de
Sorotipo 3 do vírus da dengue
Febre de Dengue hemorrágica
Imunoperoxidase
Dengue virus serotype 3
Dengue hemorrhagic fever
Immunoperoxidase
title_short Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil
title_full Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil
title_fullStr Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil
title_full_unstemmed Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil
title_sort Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil
dc.creator.none.fl_str_mv Oliveira, C. A. Basílio de
Aguiar, G. R.
Baldanza, M. S.
Barth, Ortrud Monika
Eyer-Silva, W. A.
Paes, M. V.
author Oliveira, C. A. Basílio de
author_facet Oliveira, C. A. Basílio de
Aguiar, G. R.
Baldanza, M. S.
Barth, Ortrud Monika
Eyer-Silva, W. A.
Paes, M. V.
author_role author
author2 Aguiar, G. R.
Baldanza, M. S.
Barth, Ortrud Monika
Eyer-Silva, W. A.
Paes, M. V.
author2_role author
author
author
author
author
dc.subject.other.none.fl_str_mv Sorotipo 3 do vírus da dengue
Febre de Dengue hemorrágica
Imunoperoxidase
topic Sorotipo 3 do vírus da dengue
Febre de Dengue hemorrágica
Imunoperoxidase
Dengue virus serotype 3
Dengue hemorrhagic fever
Immunoperoxidase
dc.subject.en.none.fl_str_mv Dengue virus serotype 3
Dengue hemorrhagic fever
Immunoperoxidase
description Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Rio de Janeiro, RJ, Brasil.
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2019-12-04T14:19:40Z
dc.date.available.fl_str_mv 2019-12-04T14:19:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, C. S. A. Basílio de et al. Pathologic Study of a Fatal Case of Dengue-3 Virus Infection in Rio de Janeiro, Brazil. The Brazilian Journal of Infectious Diseases, Salvador, v. 9, n. 4, p. 341-347, Aug. 2005.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/37571
dc.identifier.issn.none.fl_str_mv 1413-8670
dc.identifier.doi.none.fl_str_mv 10.1590/s1413-86702005000400012
dc.identifier.eissn.none.fl_str_mv 1678-4391
identifier_str_mv OLIVEIRA, C. S. A. Basílio de et al. Pathologic Study of a Fatal Case of Dengue-3 Virus Infection in Rio de Janeiro, Brazil. The Brazilian Journal of Infectious Diseases, Salvador, v. 9, n. 4, p. 341-347, Aug. 2005.
1413-8670
10.1590/s1413-86702005000400012
1678-4391
url https://arca.fiocruz.br/handle/icict/37571
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Doenças Infecciosas
publisher.none.fl_str_mv Sociedade Brasileira de Doenças Infecciosas
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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spelling 2019-12-04T14:19:40Z2019-12-04T14:19:40Z2005OLIVEIRA, C. S. A. Basílio de et al. Pathologic Study of a Fatal Case of Dengue-3 Virus Infection in Rio de Janeiro, Brazil. The Brazilian Journal of Infectious Diseases, Salvador, v. 9, n. 4, p. 341-347, Aug. 2005.1413-8670https://arca.fiocruz.br/handle/icict/3757110.1590/s1413-867020050004000121678-4391engSociedade Brasileira de Doenças InfecciosasSorotipo 3 do vírus da dengueFebre de Dengue hemorrágicaImunoperoxidaseDengue virus serotype 3Dengue hemorrhagic feverImmunoperoxidasePathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Rio de Janeiro, RJ, Brasil.Hospital São Vicente. Rio de Janeiro, RJ, Brasil.Hospital São Vicente. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Dengue hemorrhagic fever (DHF) is a severe febrile disease, characterized by abnormalities in hemostasis and increased vascular permeability, which in some cases results in hypovolemic shock syndrome and in dengue shock syndrome. The clinical features of DHF include plasma leakage, bleeding tendency and liver involvement. We studied the histopathological features of a fatal case of dengue-3 virus infection. The patient, a 63-year old male, presented with an acute onset of severe headache, myalgia and maculopapular rash. Tissue fragments (liver, spleen, lung, heart, kidney and lymph nodes) were collected for light microscopy studies and stained by standard methods. Histopathology revealed severe tissue damage, caused by intense hemorrhage, interstitial edema and inflammation. Some tissue sections were also processed with the immunoperoxidase reaction, which revealed the dengue viral antigen. Dengue-3 virus was isolated and identified with electron microscopy in a C6/36 cell culture inoculated with the patient's serum. Viral particles were detected in the infected cell culture.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZOliveira, C. A. Basílio deAguiar, G. R.Baldanza, M. S.Barth, Ortrud MonikaEyer-Silva, W. A.Paes, M. 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