Variabilidade da frequência cardíaca em pacientes com distrofia miotônica tipo 1
Background: Cardiac involvement is common in myotonic dystrophy (MD) patients. Heart rate variability (HRV) is a simple and reliable technique that can be useful for studying the influence of the autonomic nervous system on the heart. Objective: Study heart rate variability in patients with type 1 M...
| Autores: | , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2012 |
| País: | Brasil |
| Recursos: | Universidade Federal do Rio Grande do Norte (UFRN) |
| Repositório: | Repositório Institucional da UFRN |
| Idioma: | português |
| OAI Identifier: | oai:repositorio.ufrn.br:123456789/54264 |
| Acesso em linha: | https://repositorio.ufrn.br/handle/123456789/54264 https://doi.org/10.1590/S0066-782X2012005000021 |
| Access Level: | Acceso aberto |
| Palavra-chave: | frequência cardíaca distrofia miotônica análise espectral sistema nervoso autônomo heart rate autonomic nervous system myotonic dystrophy spectrum analysis |
| Resumo: | Background: Cardiac involvement is common in myotonic dystrophy (MD) patients. Heart rate variability (HRV) is a simple and reliable technique that can be useful for studying the influence of the autonomic nervous system on the heart. Objective: Study heart rate variability in patients with type 1 MD. Methods: We studied HRV during 5-minute recordings in MD patients and in a healthy control group. We analyzed frequency domains (LF and HF) in normalized units (nu) and sympathovagal balance, in the sitting and supine position. Results: Seventeen patients (10 men and 7 women) and seventeen matched healthy individuals (10 men and 7 women) were studied. Sympathetic and parasympathetic modulations of the heart increased in male MD patients from supine to sitting position in 19% of LFnu and the LF/HF ratio rose by 42.3%. In the sitting position, male MD patients exhibited significantly higher sympathovagal balances in 50.9% compared to healthy control individuals. HRV was influenced by both gender and disease. Gender influenced LFnu in the supine position while the LF/HF ratio and HFnu were affected in both positions. Post hoc analyses showed that gender significantly impacts MD patients and healthy individuals in different ways (p < 0.01). The low frequency domain in the sitting position (LFnu) was significantly influenced by the disease. Conclusion: The results of this study suggest that the sympathetic drive in middle-aged male MD patients who are not severely impaired and present moderate disease duration seems to be greater than in healthy matched individuals. |
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