Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine

Olanzapine (OLZ) is a drug that is used in the treatment of schizophrenia and other psychoses, and it belongs to the thienobenzodiazepine class. The OLZ molecule has low solubility decreasing bioavailability, but has high permeability in membrane biological being classified as a Class II drug substa...

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Detalles Bibliográficos
Autores: Pergher, Sibele Berenice Castellã, Oliveira, Artur S., Alcântara, Ana C.S.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:Brasil
Institución:Universidade Federal do Rio Grande do Norte (UFRN)
Repositorio:Repositório Institucional da UFRN
Idioma:inglés
OAI Identifier:oai:repositorio.ufrn.br:123456789/29580
Acceso en línea:https://repositorio.ufrn.br/jspui/handle/123456789/29580
Access Level:acceso abierto
Palabra clave:Bionanocomposite
Hybrid
Montmorillonite
Xanthan gum
Alginate
Olanzapine
Drug delivery
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spelling Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapineBionanocompositeHybridMontmorilloniteXanthan gumAlginateOlanzapineDrug deliveryOlanzapine (OLZ) is a drug that is used in the treatment of schizophrenia and other psychoses, and it belongs to the thienobenzodiazepine class. The OLZ molecule has low solubility decreasing bioavailability, but has high permeability in membrane biological being classified as a Class II drug substance according to the Biopharmaceutics Classification System. It was reported many side effects of administering OLZ orally. So, in order to increase the bioavailability of drug and possibly reducing some of side effects, this paper proposes a new material able to controllably release the drug in the body. To control the dissolution rate, this work proposes a system that incorporates the drug into montmorillonite (MMT) dispersed in a mixture of alginate (ALG) and xanthan gum (XG) biopolymers. The proposed hybrids and bionanocomposites were characterized by several physicochemical techniques, including XRD, IR-ATR, TG DTA, SEM-EDS and HPLC. The characterization data confirmed the intercalation of the OLZ into the MMT by the ion exchange process, as well as the interaction of the MMT-OLZ with the biopolymers. The release test, conducted under various pH conditions, showed that the proposed system exhibited a more controlled drug release than commercial tablets, indicating that the ALG-XG/MMT-OLZ bionanocomposite can act as a controlled release system for OLZElsevier2020-07-13T17:16:01Z2020-07-13T17:16:01Z2017-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfOLIVEIRA, Artur S.; ALCÂNTARA, Ana C.S.; PERGHER, Sibele Berenice Castellã. Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine. Materials Science And Engineering: C, [s.l.], v. 75, p. 1250-1258, jun. 2017. ISSN 0928-4931. Disponível em https://www.sciencedirect.com/science/article/abs/pii/S092849311631685X?via%3Dihub. Acesso em: 13 jul. 2020. http://dx.doi.org/10.1016/j.msec.2017.03.0440928-4931https://repositorio.ufrn.br/jspui/handle/123456789/2958010.1016/j.msec.2017.03.044ark:/41046/0013000011vkdAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNPergher, Sibele Berenice CastellãOliveira, Artur S.Alcântara, Ana C.S.2021-02-15T21:58:53Zoai:repositorio.ufrn.br:123456789/29580Repositório InstitucionalPUBhttp://repositorio.ufrn.br/oai/repositorio@bczm.ufrn.bropendoar:2021-02-15T21:58:53Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.none.fl_str_mv Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine
title Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine
spellingShingle Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine
Pergher, Sibele Berenice Castellã
Bionanocomposite
Hybrid
Montmorillonite
Xanthan gum
Alginate
Olanzapine
Drug delivery
title_short Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine
title_full Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine
title_fullStr Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine
title_full_unstemmed Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine
title_sort Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine
dc.creator.none.fl_str_mv Pergher, Sibele Berenice Castellã
Oliveira, Artur S.
Alcântara, Ana C.S.
author Pergher, Sibele Berenice Castellã
author_facet Pergher, Sibele Berenice Castellã
Oliveira, Artur S.
Alcântara, Ana C.S.
author_role author
author2 Oliveira, Artur S.
Alcântara, Ana C.S.
author2_role author
author
dc.subject.por.fl_str_mv Bionanocomposite
Hybrid
Montmorillonite
Xanthan gum
Alginate
Olanzapine
Drug delivery
topic Bionanocomposite
Hybrid
Montmorillonite
Xanthan gum
Alginate
Olanzapine
Drug delivery
description Olanzapine (OLZ) is a drug that is used in the treatment of schizophrenia and other psychoses, and it belongs to the thienobenzodiazepine class. The OLZ molecule has low solubility decreasing bioavailability, but has high permeability in membrane biological being classified as a Class II drug substance according to the Biopharmaceutics Classification System. It was reported many side effects of administering OLZ orally. So, in order to increase the bioavailability of drug and possibly reducing some of side effects, this paper proposes a new material able to controllably release the drug in the body. To control the dissolution rate, this work proposes a system that incorporates the drug into montmorillonite (MMT) dispersed in a mixture of alginate (ALG) and xanthan gum (XG) biopolymers. The proposed hybrids and bionanocomposites were characterized by several physicochemical techniques, including XRD, IR-ATR, TG DTA, SEM-EDS and HPLC. The characterization data confirmed the intercalation of the OLZ into the MMT by the ion exchange process, as well as the interaction of the MMT-OLZ with the biopolymers. The release test, conducted under various pH conditions, showed that the proposed system exhibited a more controlled drug release than commercial tablets, indicating that the ALG-XG/MMT-OLZ bionanocomposite can act as a controlled release system for OLZ
publishDate 2017
dc.date.none.fl_str_mv 2017-06-01
2020-07-13T17:16:01Z
2020-07-13T17:16:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv OLIVEIRA, Artur S.; ALCÂNTARA, Ana C.S.; PERGHER, Sibele Berenice Castellã. Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine. Materials Science And Engineering: C, [s.l.], v. 75, p. 1250-1258, jun. 2017. ISSN 0928-4931. Disponível em https://www.sciencedirect.com/science/article/abs/pii/S092849311631685X?via%3Dihub. Acesso em: 13 jul. 2020. http://dx.doi.org/10.1016/j.msec.2017.03.044
0928-4931
https://repositorio.ufrn.br/jspui/handle/123456789/29580
10.1016/j.msec.2017.03.044
dc.identifier.dark.fl_str_mv ark:/41046/0013000011vkd
identifier_str_mv OLIVEIRA, Artur S.; ALCÂNTARA, Ana C.S.; PERGHER, Sibele Berenice Castellã. Bionanocomposite systems based on montmorillonite and biopolymers for the controlled release of olanzapine. Materials Science And Engineering: C, [s.l.], v. 75, p. 1250-1258, jun. 2017. ISSN 0928-4931. Disponível em https://www.sciencedirect.com/science/article/abs/pii/S092849311631685X?via%3Dihub. Acesso em: 13 jul. 2020. http://dx.doi.org/10.1016/j.msec.2017.03.044
0928-4931
10.1016/j.msec.2017.03.044
ark:/41046/0013000011vkd
url https://repositorio.ufrn.br/jspui/handle/123456789/29580
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution 3.0 Brazil
http://creativecommons.org/licenses/by/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 3.0 Brazil
http://creativecommons.org/licenses/by/3.0/br/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
instname:Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN
instname_str Universidade Federal do Rio Grande do Norte (UFRN)
instacron_str UFRN
institution UFRN
reponame_str Repositório Institucional da UFRN
collection Repositório Institucional da UFRN
repository.name.fl_str_mv Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)
repository.mail.fl_str_mv repositorio@bczm.ufrn.br
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score 15,301603

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