Clinical, thermographic, and tensiometric evaluation of rat cutaneous wounds treated with collagen gel associated with F18 bioactive glass

Purpose: To evaluate the association of collagen gel with F18 bioactive glass (BG) in the healing of non-contaminated cutaneous wounds induced in healthy Wistar rats. Methods: One hundred twelve adult and healthy Wistar rats were randomly divided into four groups (n = 28): saline solution (0.9%); he...

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Detalles Bibliográficos
Autores: da Silva, Bruna Martins [UNESP], Dos Santos, Ivan Felismino Charas [UNESP], Mancuso, Paula [UNESP], Pereira, Letícia Albuquerque Fortes [UNESP], Moroz, Ivan [UNESP], Gallina, Marina Frazatti [UNESP], Tsunemi, Miriam Harumi [UNESP], Souza, Marina Trevelin, Pellizzon, Claudia Helena [UNESP], Júnior, José Ivaldo Siqueira Silva [UNESP], Brandão, Cláudia Valéria Seullner [UNESP], Alves, Liandra Amara Garcia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/302306
Acceso en línea:http://dx.doi.org/10.1590/acb399424
https://hdl.handle.net/11449/302306
Access Level:acceso abierto
Palabra clave:Biocompatible Materials
Collagen
Materials Testing
Skin
Wound Healing
Descripción
Sumario:Purpose: To evaluate the association of collagen gel with F18 bioactive glass (BG) in the healing of non-contaminated cutaneous wounds induced in healthy Wistar rats. Methods: One hundred twelve adult and healthy Wistar rats were randomly divided into four groups (n = 28): saline solution (0.9%); healing ointment based on allantoin and zinc oxide; collagen gel; and association of F18 BG powder and collagen gel. All the rats underwent the creation of a 3-cm diameter wound in their dorsal region. Macroscopic, thermographic, and tensiometric evaluations of the wound were performed. Results: The presence of granulation tissue varied significantly in and between the groups. The surface temperature assessed through thermography of wounds treated with saline solution (0.9%) increased significantly over time and between the groups. No difference was identified regarding tensiometry. Conclusion: Collagen gel associated with F18 BG induced beneficial healing effects on non-contaminated cutaneous wounds in Wistar rats, which included the induction of increased blood perfusion as assessed through thermography.

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