Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido?
Several studies show that portions of intramyocardial coronary arteries are spared of arteriosclerosis, involving morphological, embryological, biochemical and pathophysiological aspects. Endothelial function is significantly affected in the segment of transition, as estimated by the vasoactive resp...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2011 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | inglés portugués |
| OAI Identifier: | oai:repositorio.unesp.br:11449/72538 |
| Acceso en línea: | http://dx.doi.org/10.5935/1678-9741.20110020 http://hdl.handle.net/11449/72538 |
| Access Level: | acceso abierto |
| Palabra clave: | Coronary circulation Endothelium Myocardial bridging ACE protein, human dipeptidyl carboxypeptidase endothelin 1 adipose tissue coronary artery blood flow coronary artery disease coronary blood vessel histology human metabolism myocardial bridging paracrine signaling pathology pathophysiology physiology prenatal development review vascular endothelium Adipose Tissue Coronary Artery Disease Coronary Circulation Coronary Vessels Endothelin-1 Endothelium, Vascular Humans Myocardial Bridging Paracrine Communication Peptidyl-Dipeptidase A |
| Sumario: | Several studies show that portions of intramyocardial coronary arteries are spared of arteriosclerosis, involving morphological, embryological, biochemical and pathophysiological aspects. Endothelial function is significantly affected in the segment of transition, as estimated by the vasoactive response to Ach. These findings suggest that myocardial bridge can provide protection against arteriosclerosis by counteracting the negative effects of endothelial dysfunction. The intramyocardial portion's protection phenomenon deserves further scientific research on all research fronts. Improved morphological, biomechanical and especially physiological and embryological knowledge may be the key to a future window of opportunity for chronic arterial disease therapy and prevention. In addition, this review discusses possible therapeutic approaches for symptomatic coronary ischemia caused by myocardial bridges. |
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