AIDS and non-AIDS severe morbidity associated with hospitalizations among HIV-infected patients in two regions with universal access to care and antiretroviral therapy, France and Brazil, 2000-2008: hospital-based cohort studies

Collaborators: Dabis F, Bonnet F, Breilh D, Dabis F, Dupon M, Chêne G, Fleury H, Malvy D, Mercié P, Pellegrin I, Morlat P, Neau D, Pellegrin JL, Thiébaut R, Bouchet S, Gaborieau V, Lacoste D, Tchamgoué S, Wittkop L, Chêne G, Dabis F, Thiébaut R, Bruyand M, Lawson-Ayayi S, Wittkop L, Morlat P, Bonnet...

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Autores: Luz, Paula Mendes, Bruyand, Mathias, Ribeiro, Sayonara, Bonnet, Fabrice, Moreira, Ronaldo Ismerio, Hessamfar, Mojgan, Campos, Dayse Perreira, Greib, Carine, Cazanave, Charles, Veloso, Valdiléa G., Dabis, François, Grinsztejn, Beatriz, Chêne, Geneviève
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Brasil
Institución:Fundação Oswaldo Cruz (FIOCRUZ)
Repositorio:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglés
OAI Identifier:oai:arca.fiocruz.br:icict/29308
Acceso en línea:https://arca.fiocruz.br/handle/icict/29308
Access Level:acceso abierto
Palabra clave:HIV
AIDS
Antiretroviral therapy
Severe morbidity
Hospitalization
Cohort study
Brazil
France
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dc.title.none.fl_str_mv AIDS and non-AIDS severe morbidity associated with hospitalizations among HIV-infected patients in two regions with universal access to care and antiretroviral therapy, France and Brazil, 2000-2008: hospital-based cohort studies
title AIDS and non-AIDS severe morbidity associated with hospitalizations among HIV-infected patients in two regions with universal access to care and antiretroviral therapy, France and Brazil, 2000-2008: hospital-based cohort studies
spellingShingle AIDS and non-AIDS severe morbidity associated with hospitalizations among HIV-infected patients in two regions with universal access to care and antiretroviral therapy, France and Brazil, 2000-2008: hospital-based cohort studies
Luz, Paula Mendes
HIV
AIDS
Antiretroviral therapy
Severe morbidity
Hospitalization
Cohort study
Brazil
France
title_short AIDS and non-AIDS severe morbidity associated with hospitalizations among HIV-infected patients in two regions with universal access to care and antiretroviral therapy, France and Brazil, 2000-2008: hospital-based cohort studies
title_full AIDS and non-AIDS severe morbidity associated with hospitalizations among HIV-infected patients in two regions with universal access to care and antiretroviral therapy, France and Brazil, 2000-2008: hospital-based cohort studies
title_fullStr AIDS and non-AIDS severe morbidity associated with hospitalizations among HIV-infected patients in two regions with universal access to care and antiretroviral therapy, France and Brazil, 2000-2008: hospital-based cohort studies
title_full_unstemmed AIDS and non-AIDS severe morbidity associated with hospitalizations among HIV-infected patients in two regions with universal access to care and antiretroviral therapy, France and Brazil, 2000-2008: hospital-based cohort studies
title_sort AIDS and non-AIDS severe morbidity associated with hospitalizations among HIV-infected patients in two regions with universal access to care and antiretroviral therapy, France and Brazil, 2000-2008: hospital-based cohort studies
dc.creator.none.fl_str_mv Luz, Paula Mendes
Bruyand, Mathias
Ribeiro, Sayonara
Bonnet, Fabrice
Moreira, Ronaldo Ismerio
Hessamfar, Mojgan
Campos, Dayse Perreira
Greib, Carine
Cazanave, Charles
Veloso, Valdiléa G.
Dabis, François
Grinsztejn, Beatriz
Chêne, Geneviève
author Luz, Paula Mendes
author_facet Luz, Paula Mendes
Bruyand, Mathias
Ribeiro, Sayonara
Bonnet, Fabrice
Moreira, Ronaldo Ismerio
Hessamfar, Mojgan
Campos, Dayse Perreira
Greib, Carine
Cazanave, Charles
Veloso, Valdiléa G.
Dabis, François
Grinsztejn, Beatriz
Chêne, Geneviève
author_role author
author2 Bruyand, Mathias
Ribeiro, Sayonara
Bonnet, Fabrice
Moreira, Ronaldo Ismerio
Hessamfar, Mojgan
Campos, Dayse Perreira
Greib, Carine
Cazanave, Charles
Veloso, Valdiléa G.
Dabis, François
Grinsztejn, Beatriz
Chêne, Geneviève
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.en.none.fl_str_mv HIV
AIDS
Antiretroviral therapy
Severe morbidity
Hospitalization
Cohort study
Brazil
France
topic HIV
AIDS
Antiretroviral therapy
Severe morbidity
Hospitalization
Cohort study
Brazil
France
description Collaborators: Dabis F, Bonnet F, Breilh D, Dabis F, Dupon M, Chêne G, Fleury H, Malvy D, Mercié P, Pellegrin I, Morlat P, Neau D, Pellegrin JL, Thiébaut R, Bouchet S, Gaborieau V, Lacoste D, Tchamgoué S, Wittkop L, Chêne G, Dabis F, Thiébaut R, Bruyand M, Lawson-Ayayi S, Wittkop L, Morlat P, Bonnet F, Bernard N, Hessamfar M, Lacoste D, Vandenhende MA, Dupon M, Dauchy FA, Dutronc H, Mercié P, Duffau P, Schmeltz JR, Malvy D, Pistone T, Receveur MC, Neau D, Cazanave C, Ochoa A, Vareil MO, Pellegrin JL, Viallard JF, Greib C, Lazaro E, Fleury H, Lafon ME, Reigadas S, Trimoulet P, Breilh D, Molimard M, Bouchet S, Titier K, Moreau JF, Pellegrin I, Haramburu F, Miremont-Salamé G, Dupont A, Gerard Y, Caunègre L, André K, Bonnal F, Farbos S, Gemain MC, Ceccaldi J, Caubet O, Tchamgoué S, De Witte S, Courtault C, Monlun E, Gaborieau V, Lataste P, Meraud JP, Chossat I, Blaizeau MJ, Bruyand M, Conte V, Decoin M, Delaune J, Delveaux S, Diarra F, D'Ivernois C, Frosch A, Geffard S, Hanappier C, Lawson-Ayayi S, Lenaud E, Leleux O, Le Marec F, Leray J, Louis I, Palmer G, Pougetoux A, Sicard X, Touchard D, Uwamaliya-Nziyumvira B.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2018-10-03T19:21:11Z
dc.date.available.fl_str_mv 2018-10-03T19:21:11Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv LUZ, Paula Mendes et al. AIDS and Non-AIDS Severe Morbidity Associated with Hospitalizations among HIV-Infected Patients in Two Regions with Universal Access to Care and Antiretroviral Therapy, France and Brazil, 2000–2008: Hospital-Based Cohort Studies. BMC Infectious Diseases, v. 14, p. 1-13, May 2014.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/29308
dc.identifier.issn.none.fl_str_mv 1471-2334
dc.identifier.doi.none.fl_str_mv 10.1186/1471-2334-14-278
dc.identifier.eissn.none.fl_str_mv 1471-2334
identifier_str_mv LUZ, Paula Mendes et al. AIDS and Non-AIDS Severe Morbidity Associated with Hospitalizations among HIV-Infected Patients in Two Regions with Universal Access to Care and Antiretroviral Therapy, France and Brazil, 2000–2008: Hospital-Based Cohort Studies. BMC Infectious Diseases, v. 14, p. 1-13, May 2014.
1471-2334
10.1186/1471-2334-14-278
url https://arca.fiocruz.br/handle/icict/29308
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institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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spelling 2018-10-03T19:21:11Z2018-10-03T19:21:11Z2014LUZ, Paula Mendes et al. AIDS and Non-AIDS Severe Morbidity Associated with Hospitalizations among HIV-Infected Patients in Two Regions with Universal Access to Care and Antiretroviral Therapy, France and Brazil, 2000–2008: Hospital-Based Cohort Studies. BMC Infectious Diseases, v. 14, p. 1-13, May 2014.1471-2334https://arca.fiocruz.br/handle/icict/2930810.1186/1471-2334-14-2781471-2334Collaborators: Dabis F, Bonnet F, Breilh D, Dabis F, Dupon M, Chêne G, Fleury H, Malvy D, Mercié P, Pellegrin I, Morlat P, Neau D, Pellegrin JL, Thiébaut R, Bouchet S, Gaborieau V, Lacoste D, Tchamgoué S, Wittkop L, Chêne G, Dabis F, Thiébaut R, Bruyand M, Lawson-Ayayi S, Wittkop L, Morlat P, Bonnet F, Bernard N, Hessamfar M, Lacoste D, Vandenhende MA, Dupon M, Dauchy FA, Dutronc H, Mercié P, Duffau P, Schmeltz JR, Malvy D, Pistone T, Receveur MC, Neau D, Cazanave C, Ochoa A, Vareil MO, Pellegrin JL, Viallard JF, Greib C, Lazaro E, Fleury H, Lafon ME, Reigadas S, Trimoulet P, Breilh D, Molimard M, Bouchet S, Titier K, Moreau JF, Pellegrin I, Haramburu F, Miremont-Salamé G, Dupont A, Gerard Y, Caunègre L, André K, Bonnal F, Farbos S, Gemain MC, Ceccaldi J, Caubet O, Tchamgoué S, De Witte S, Courtault C, Monlun E, Gaborieau V, Lataste P, Meraud JP, Chossat I, Blaizeau MJ, Bruyand M, Conte V, Decoin M, Delaune J, Delveaux S, Diarra F, D'Ivernois C, Frosch A, Geffard S, Hanappier C, Lawson-Ayayi S, Lenaud E, Leleux O, Le Marec F, Leray J, Louis I, Palmer G, Pougetoux A, Sicard X, Touchard D, Uwamaliya-Nziyumvira B.IPEC/FIOCRUZ Cohort and the Aquitaine ANRS C03 Study Group.This study was partially funded by the grant “Cooperation Franco-Bresilienne en Recherche Medicale Accord Inserm (Institut National de la Santé et de la Recherche Medicale)/FIOCRUZ 2010”. The ANRS C03 Aquitaine Cohort is supported by grants from the French Agency for AIDS and hepatitis research (ANRS) through the HIV Cohort Program (AC7) together with the Bordeaux School of Public Health (ISPED - Bordeaux University), Inserm CIC-EC7 and U897 (Bordeaux) and the COREVIH Aquitaine (Bordeaux University Hospital). BG and PML acknowledge funding from the National Council of Technological and Scientific Development (CNPq) and the Research Funding Agency of the State of Rio de Janeiro (FAPERJ). The funding bodies had no role in the design, collection, analysis, or interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Centre Hospitalier Universitaire de Bordeaux. Pôle de Santé Publique. COREVIH Aquitaine. France / INSERM. ISPED. Centre Inserm U897- Epidemiologie-Biostatistique & CIC-EC7. France.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Centre Hospitalier Universitaire de Bordeaux. Pôle de Santé Publique. COREVIH Aquitaine. France / INSERM. ISPED. Centre Inserm U897- Epidemiologie-Biostatistique & CIC-EC7. France.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Centre Hospitalier Universitaire de Bordeaux. Pôle de Santé Publique. COREVIH Aquitaine. France / INSERM. ISPED. Centre Inserm U897- Epidemiologie-Biostatistique & CIC-EC7. France.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Centre Hospitalier Universitaire de Bordeaux. Hôpital Haut-Lévèque. Bordeaux, France.Centre Hospitalier Universitaire de Bordeaux. Hôpital Pellegrin. Bordeaux, France.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Centre Hospitalier Universitaire de Bordeaux. Pôle de Santé Publique. COREVIH Aquitaine. France / INSERM. ISPED. Centre Inserm U897- Epidemiologie-Biostatistique & CIC-EC7. France.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Centre Hospitalier Universitaire de Bordeaux. Pôle de Santé Publique. COREVIH Aquitaine. France / INSERM. ISPED. Centre Inserm U897- Epidemiologie-Biostatistique & CIC-EC7. France.Background: In high-income settings, the spectrum of morbidity and mortality experienced by Human Immunodeficiency Virus (HIV)-infected individuals receiving combination antiretroviral therapy (cART) has switched from predominantly AIDS-related to non-AIDS-related conditions. In the context of universal access to care, we evaluated whether that shift would apply in Brazil, a middle-income country with universal access to treatment, as compared to France. Methods: Two hospital-based cohorts of HIV-infected individuals were used for this analysis: the ANRS CO3 Aquitaine Cohort in South Western France and the Evandro Chagas Research Institute (IPEC) Cohort of the Oswaldo Cruz Foundation in Rio de Janeiro, Brazil. Severe morbid events (AIDS- and non-AIDS-related) were defined as all clinical diagnoses associated with a hospitalization of ≥48 hours. Trends in the incidence rate of events and their determinants were estimated while adjusting for within-subject correlation using generalized estimating equations models with an auto-regressive correlation structure and robust standard errors. Result: Between January 2000 and December 2008, 7812 adult patients were followed for a total of 41,668 personyears (PY) of follow-up. Throughout the study period, 90% of the patients were treated with cART. The annual incidence rate of AIDS and non-AIDS events, and of deaths significantly decreased over the years, from 6.2, 21.1, and 1.9 AIDS, non-AIDS events, and deaths per 100 PY in 2000 to 4.3, 14.9, and 1.5/100 PY in 2008. The annual incidence rates of non-AIDS events surpassed that of AIDS-events during the entire study period. High CD4 cell counts were associated with a lower incidence rate of AIDS and non-AIDS events as well as with lower rates of specific non-AIDS events, such as bacterial, hepatic, viral, neurological, and cardiovascular conditions. Adjusted analysis showed that severe morbidity was associated with lower CD4 counts and higher plasma HIV RNAs but not with setting (IPEC versus Aquitaine). Conclusions: As information on severe morbidities for HIV-infected patients remain scarce, data on hospitalizations are valuable to identify priorities for case management and to improve the quality of life of patients with a chronic disease requiring life-long treatment. Immune restoration is highly effective in reducing AIDS and non-AIDS severe morbid events irrespective of the setting.engAIDS and non-AIDS severe morbidity associated with hospitalizations among HIV-infected patients in two regions with universal access to care and antiretroviral therapy, France and Brazil, 2000-2008: hospital-based cohort studiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHIVAIDSAntiretroviral therapySevere morbidityHospitalizationCohort studyBrazilFranceinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLuz, Paula MendesBruyand, MathiasRibeiro, SayonaraBonnet, FabriceMoreira, Ronaldo IsmerioHessamfar, MojganCampos, Dayse PerreiraGreib, CarineCazanave, CharlesVeloso, Valdiléa G.Dabis, FrançoisGrinsztejn, BeatrizChêne, GenevièveLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://arca.fiocruz.br/bitstreams/097a3306-93c1-4165-a271-df61b2deb834/download586c046dcfeef936e32f0323bb9a47c0MD51falseAnonymousREADORIGINALAIDS and non-AIDS severe morbidity associated with hospitalizations_Paula_Luz_etal_INI_Lapclin_2014.pdfAIDS and non-AIDS severe morbidity associated with hospitalizations_Paula_Luz_etal_INI_Lapclin_2014.pdfapplication/pdf256510https://arca.fiocruz.br/bitstreams/da5b458f-2473-4e95-8261-042a33ae76ca/downloaddc71d13277ec68116fe84549b7e98587MD52trueAnonymousREADTEXTAIDS and non-AIDS severe morbidity associated with hospitalizations_Paula_Luz_etal_INI_Lapclin_2014.pdf.txtAIDS and non-AIDS severe morbidity associated with hospitalizations_Paula_Luz_etal_INI_Lapclin_2014.pdf.txtExtracted texttext/plain100217https://arca.fiocruz.br/bitstreams/7997374d-7b62-4ce3-9037-c89a2be08ea7/download08d973a5a3b9abda47a86c6b4d8c3cabMD512falseAnonymousREADTHUMBNAILCapa_page-0001.jpgCapa_page-0001.jpgimage/jpeg993746https://arca.fiocruz.br/bitstreams/35550b5a-8435-4691-8236-bea027ce53a9/downloade510a2b7e6cdd152588fd9b625dbce45MD54falseAnonymousREADAIDS and non-AIDS severe morbidity associated with hospitalizations_Paula_Luz_etal_INI_Lapclin_2014.pdf.jpgAIDS and non-AIDS severe morbidity associated with hospitalizations_Paula_Luz_etal_INI_Lapclin_2014.pdf.jpgGenerated Thumbnailimage/jpeg42775https://arca.fiocruz.br/bitstreams/2eedb393-47d6-4919-b7e6-aa52d82a68ca/download4823feb55f7b2142b5fb834c864a49b0MD513falseAnonymousREADicict/293082025-12-10 13:02:57.71open.accessoai:arca.fiocruz.br:icict/29308https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-12-10T16:02:57Repositório Institucional da FIOCRUZ (ARCA) - 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score 15,301603

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