A Ceruloplasmina Como Enzima Marcadora de Atividade Neoplásica Maligna
Hyperceruloplasminemia was detected in U strain isogenic male rats bearing a syngeneic sarcoma in all phases of neoplasm evolution. Normal levels of ceruloplasmin oxidase activity were only observed after lhe first dose of intraperitoneally administered cyclophosphamide (100 mg/kg). However subseque...
| Authors: | , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2023 |
| Country: | Brasil |
| Institution: | Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) |
| Repository: | Revista Brasileira de Cancerologia (Online) |
| Language: | Portuguese |
| OAI Identifier: | oai:rbc.inca.gov.br:article/3460 |
| Online Access: | https://rbc.inca.gov.br/index.php/revista/article/view/3460 |
| Access Level: | Open access |
| Keyword: | Ceruloplasmina/metabolismo Ceruloplasmina/efeitos dos fármacos Sarcoma Experimental/enzimologia Ciclofosfamida/farmacologia Ceruloplasmin/metabolism Ceruloplasmin/drug effects Sarcoma, Experimental/enzymology Cyclophosphamide/pharmacology Ceruloplasmina/efectos de los fármacos Sarcoma Experimental/enzimología Ciclofosfamida/farmacología |
| Summary: | Hyperceruloplasminemia was detected in U strain isogenic male rats bearing a syngeneic sarcoma in all phases of neoplasm evolution. Normal levels of ceruloplasmin oxidase activity were only observed after lhe first dose of intraperitoneally administered cyclophosphamide (100 mg/kg). However subsequent weekly therapy with the drug did not prevent the return of high levels of sérum ceruloplasmin in the tumor hosts. Healthy rats treated similarly with cyclophosphamide presented a fall in the enzyme activity after the first dose. The constant hyperceruloplasminemia observed suggests the presence of viable latent sarcoma celles and can serve as a biochemical test to monitorize the malignant process. |
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