Aspectos epidemiológicos, clínicos e microbiológicos da associação entre o transtorno afetivo bipolar e periodontite
Periodontal diseases comprise a group of infectious diseases, resulting from the interaction between the supra and subgingival biofilms and immuno-inflammatory response generated by the host. Several risk factors and variables may interfere and modulate the relation between microbial challenge and t...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | Brasil |
| Institución: | Universidade Federal de Minas Gerais (UFMG) |
| Repositorio: | Repositório Institucional da UFMG |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.ufmg.br:1843/ODON-AE6RGC |
| Acceso en línea: | http://hdl.handle.net/1843/ODON-AE6RGC |
| Access Level: | acceso abierto |
| Palabra clave: | Periodontite Transtorno afetivo bipolar Epidemiologia Periodontite crônica Transtorno bipolar |
| Sumario: | Periodontal diseases comprise a group of infectious diseases, resulting from the interaction between the supra and subgingival biofilms and immuno-inflammatory response generated by the host. Several risk factors and variables may interfere and modulate the relation between microbial challenge and the host response. Bipolar affective disorder (BAD) is a classic psychiatric syndrome characterized by oscillatory periods between mental states of normality and balance (euthymia), abnormally low mood (depression) and abnormally high state (mania).Although little investigated and with conflicting data, bipolar affective disorder is a behavioral factor associated to the periodontal disease. In addition, little is known about its interference with the microbial response and immunological, to periodontitis. This study aimed to determine the periodontal conditions, epidemiological and microbiological profile of individuals with BAD. Specifically it aimed to: a) determine the prevalence of periodontitis in a population diagnosed with BAD; b) check the influence of risk variables on the association between BAD and periodontitis; c) determine the frequency of periodontopathogens of the red complex (Treponema denticola, Tannerella forsythia and Porphyromonas gingivalis), the Aggregatibacter actinomycetemcomitans species and the total bacterial load in individuals with BAD with periodontitis. The study consisted of a convenience sample of 156 individuals with BAD selected in the Mental Health Hospital, attached to the Hospital of the Federal University of Minas Gerais (HC-UFMG). Subjects were assessed through clinical periodontal parameters,social risk variables / demographic and microbiological collection, analyzed by qPCR (Reaction Polymerase Chain in Real Time). The results showed a prevalence of 59% of periodontitis among individuals with BAD. Of these, 90.2% had moderate chronic periodontitis and 9.8% the advanced one. As to the extent of periodontitis, in 81.5% the disease presented itself as localized and 18.5% as general. It was observed a strong significant association between periodontitis and the use of illicit drugs, in which nonusers showed 56.8% of periodontitis and users 100% of periodontitis. The phase of depression in individuals with BAD, was strongly associated with the occurrence of periodontitis (p <0.001). Individuals with BAD and periodontitis had a bacteria count of the red complex, Aggregatibacter actinomycetemcomitans species and total bacterial load, significantly higher than those without periodontitis.Additionally, it was found that the group of individuals with advanced and generalized periodontitis presented significantly higher microbial counts compared to the group of individuals with moderate and localized periodontitis in relation to the bacteria of the red complex together and when analyzed individually. The final multivariate logistic regressionmodel showed that the probability of an individual having periodontitis was higher in depression phases (OR = 28,94, 95% CI = 4,44-177,27; p<0.001) compared to individuals in |
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