Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment

Sialorrhea is characterized by an increase in salivation. One of the adverse reactions of scopolamine is the decrease of salivary volume. Natural rubber latex can be used as a carrier matrix. This study developed and characterized a transdermal drug delivery system using natural rubber latex membran...

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Detalles Bibliográficos
Autores: Morise, B. T. [UNESP], Chagas, A. L.D. [UNESP], Barros, N. R. [UNESP], Miranda, M. C.R. [UNESP], Borges, F. A. [UNESP], Gemeinder, J. L.P. [UNESP], Silva, R. G. [UNESP], Paulino, C. G. [UNESP], Herculano, R. D. [UNESP], Norberto, A. M.Q.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/186957
Acceso en línea:http://dx.doi.org/10.1080/00914037.2018.1506984
http://hdl.handle.net/11449/186957
Access Level:acceso abierto
Palabra clave:biomaterial
natural rubber latex
scopolamine
Sialorrhea
sustained release
Descripción
Sumario:Sialorrhea is characterized by an increase in salivation. One of the adverse reactions of scopolamine is the decrease of salivary volume. Natural rubber latex can be used as a carrier matrix. This study developed and characterized a transdermal drug delivery system using natural rubber latex membranes carried with scopolamine butylbromide, using optical spectroscopy, Infrared spectroscopy, wettability, Scanning Electron Microscopy and hemolytic assays. The kinetic profile of scopolamine butylbromide showed that matrix released 96.49% of the drug and tests showed no hemolytic effects. Physico-chemical characterization and tensile tests showed that this system is a potential alternative for the treatment of sialorrhea.

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