Haptoglobin concentrations in cows with history of natural bracken fern chronic ingestion

Bracken ferns (Pteridium spp.) have been associated with intoxication in cattle and is the cause of bovine enzootic hematuria (BEH) characterized by intermittent hematuria, anemia, and poor body condition. Acute phase proteins have not previously been investigated in detail in BEH. Thus, this invest...

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Authors: Schmidt, Elizabeth Moreira dos Santos [UNESP], Minozzo, Carolina Dutra, Perotta, Joao Henrique, Locatelli-Dittrich, Rosangela, Beltrame, Olair Carlos, Brum, Juliana Sperotto, Eckersall, Peter David, Barros Filho, Ivan Roque de
Format: article
Status:Published version
Publication Date:2024
Country:Brasil
Institution:Universidade Estadual Paulista (UNESP)
Repository:Repositório Institucional da UNESP
Language:English
OAI Identifier:oai:repositorio.unesp.br:11449/309553
Online Access:http://dx.doi.org/10.1590/0103-8478cr2024004
https://hdl.handle.net/11449/309553
Access Level:Open access
Keyword:Pteridium spp
haptoglobin
cattle
hematuria
acute phase proteins.
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spelling Haptoglobin concentrations in cows with history of natural bracken fern chronic ingestionPteridium spphaptoglobincattlehematuriaacute phase proteins.Bracken ferns (Pteridium spp.) have been associated with intoxication in cattle and is the cause of bovine enzootic hematuria (BEH) characterized by intermittent hematuria, anemia, and poor body condition. Acute phase proteins have not previously been investigated in detail in BEH. Thus, this investigation determined serum concentrations of haptoglobin, selected hematological (complete blood count and fibrinogen), biochemical (total serum protein, albumin, urea, creatinine, aspartate aminotransferase, gamma glutamyl transferase, and creatine kinase), and urinary analytes, in 50 Nelore cows from farms with history of natural bracken fern chronic ingestion in the southern region of Brazil. Twenty-nine cows had macrohematuria and 21 microhematuria. From the 29 cows with macrohematuria, 13 had a countless number of erythrocytes per high power macroscopic field and anemia. All cows had dipstick proteinuria. Median haptoglobin concentrations were elevated for 47 BEH cows with a 3.9-fold increase, suggesting a chronic inflammatory response while the number of total leukocytes and segmented neutrophils were above the reference intervals for 14 cows. Besides inflammation, there is a hypothesis that bracken fern could cause hemolysis in the circulation. Therefore, there could be a larger acute phase reaction but much of the haptoglobin was being removed as it was being produced. In our study, increases in haptoglobin, creatine kinase, hyperglobulinemia and anemia were found in cows with BEH, contributing to the understanding of the chronic inflammatory response which could be associated with neoplastic lesions in the urinary bladder caused by long-term and repeated ingestion of Pteridium species.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estadual Paulista, UNESP, Fac Med Vet & Zootecnia, Botucatu, SP, BrazilUniv Fed Parana UFPR, Dept Med Vet, Curitiba, PR, BrazilUniv Glasgow, Inst Biodivers One Hlth & Vet Med, Coll Med Vet & Life Sci, Glasgow, ScotlandUniv Estadual Paulista, UNESP, Fac Med Vet & Zootecnia, Botucatu, SP, BrazilCAPES: 001Univ Federal Santa MariaUniversidade Estadual Paulista (UNESP)Universidade Federal do Paraná (UFPR)Univ Glasgow2025-04-29T20:15:55Z2024-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9http://dx.doi.org/10.1590/0103-8478cr2024004Ciencia Rural. Santa Maria: Univ Federal Santa Maria, v. 54, n. 11, 9 p., 2024.0103-8478https://hdl.handle.net/11449/30955310.1590/0103-8478cr2024004WOS:001292168500001Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCiencia Ruralinfo:eu-repo/semantics/openAccessSchmidt, Elizabeth Moreira dos Santos [UNESP]Minozzo, Carolina DutraPerotta, Joao HenriqueLocatelli-Dittrich, RosangelaBeltrame, Olair CarlosBrum, Juliana SperottoEckersall, Peter DavidBarros Filho, Ivan Roque de2025-04-30T13:33:32Zoai:repositorio.unesp.br:11449/309553Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-04-30T13:33:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Haptoglobin concentrations in cows with history of natural bracken fern chronic ingestion
title Haptoglobin concentrations in cows with history of natural bracken fern chronic ingestion
spellingShingle Haptoglobin concentrations in cows with history of natural bracken fern chronic ingestion
Schmidt, Elizabeth Moreira dos Santos [UNESP]
Pteridium spp
haptoglobin
cattle
hematuria
acute phase proteins.
title_short Haptoglobin concentrations in cows with history of natural bracken fern chronic ingestion
title_full Haptoglobin concentrations in cows with history of natural bracken fern chronic ingestion
title_fullStr Haptoglobin concentrations in cows with history of natural bracken fern chronic ingestion
title_full_unstemmed Haptoglobin concentrations in cows with history of natural bracken fern chronic ingestion
title_sort Haptoglobin concentrations in cows with history of natural bracken fern chronic ingestion
dc.creator.none.fl_str_mv Schmidt, Elizabeth Moreira dos Santos [UNESP]
Minozzo, Carolina Dutra
Perotta, Joao Henrique
Locatelli-Dittrich, Rosangela
Beltrame, Olair Carlos
Brum, Juliana Sperotto
Eckersall, Peter David
Barros Filho, Ivan Roque de
author Schmidt, Elizabeth Moreira dos Santos [UNESP]
author_facet Schmidt, Elizabeth Moreira dos Santos [UNESP]
Minozzo, Carolina Dutra
Perotta, Joao Henrique
Locatelli-Dittrich, Rosangela
Beltrame, Olair Carlos
Brum, Juliana Sperotto
Eckersall, Peter David
Barros Filho, Ivan Roque de
author_role author
author2 Minozzo, Carolina Dutra
Perotta, Joao Henrique
Locatelli-Dittrich, Rosangela
Beltrame, Olair Carlos
Brum, Juliana Sperotto
Eckersall, Peter David
Barros Filho, Ivan Roque de
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade Federal do Paraná (UFPR)
Univ Glasgow
dc.subject.por.fl_str_mv Pteridium spp
haptoglobin
cattle
hematuria
acute phase proteins.
topic Pteridium spp
haptoglobin
cattle
hematuria
acute phase proteins.
description Bracken ferns (Pteridium spp.) have been associated with intoxication in cattle and is the cause of bovine enzootic hematuria (BEH) characterized by intermittent hematuria, anemia, and poor body condition. Acute phase proteins have not previously been investigated in detail in BEH. Thus, this investigation determined serum concentrations of haptoglobin, selected hematological (complete blood count and fibrinogen), biochemical (total serum protein, albumin, urea, creatinine, aspartate aminotransferase, gamma glutamyl transferase, and creatine kinase), and urinary analytes, in 50 Nelore cows from farms with history of natural bracken fern chronic ingestion in the southern region of Brazil. Twenty-nine cows had macrohematuria and 21 microhematuria. From the 29 cows with macrohematuria, 13 had a countless number of erythrocytes per high power macroscopic field and anemia. All cows had dipstick proteinuria. Median haptoglobin concentrations were elevated for 47 BEH cows with a 3.9-fold increase, suggesting a chronic inflammatory response while the number of total leukocytes and segmented neutrophils were above the reference intervals for 14 cows. Besides inflammation, there is a hypothesis that bracken fern could cause hemolysis in the circulation. Therefore, there could be a larger acute phase reaction but much of the haptoglobin was being removed as it was being produced. In our study, increases in haptoglobin, creatine kinase, hyperglobulinemia and anemia were found in cows with BEH, contributing to the understanding of the chronic inflammatory response which could be associated with neoplastic lesions in the urinary bladder caused by long-term and repeated ingestion of Pteridium species.
publishDate 2024
dc.date.none.fl_str_mv 2024-01-01
2025-04-29T20:15:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/0103-8478cr2024004
Ciencia Rural. Santa Maria: Univ Federal Santa Maria, v. 54, n. 11, 9 p., 2024.
0103-8478
https://hdl.handle.net/11449/309553
10.1590/0103-8478cr2024004
WOS:001292168500001
url http://dx.doi.org/10.1590/0103-8478cr2024004
https://hdl.handle.net/11449/309553
identifier_str_mv Ciencia Rural. Santa Maria: Univ Federal Santa Maria, v. 54, n. 11, 9 p., 2024.
0103-8478
10.1590/0103-8478cr2024004
WOS:001292168500001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ciencia Rural
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9
dc.publisher.none.fl_str_mv Univ Federal Santa Maria
publisher.none.fl_str_mv Univ Federal Santa Maria
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1853671493900173312
score 15.300719

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