Craniopharyngiomas: intratumoral chemotherapy with interferon-alpha: a multicenter preliminary study with 60 cases

Object. the authors assessed the efficacy of intratumoral interferon-alpha (IFN alpha)-based chemotherapy in pediatric patients with cystic craniopharyngiomas.Methods. in a prospective multicenter study of 60 pediatric patients, the authors assessed the efficacy of intratumoral INF alpha 2A-based ch...

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Detalles Bibliográficos
Autores: Cavalheiro, Sergio [UNIFESP], Di Rocco, Concezzio, Valenzuela, Sergio, Dastoli, Patricia A. [UNIFESP], Tamburrini, Gianpiero, Massimi, Lucca, Nicacio, Jardel M. [UNIFESP], Faquini, Igor V. [UNIFESP], Ierardi, Daniela F. [UNIFESP], Silva, Nasjla Saba [UNIFESP], Pettorini, Benedetta Ludovica, Toledo, Silvia Regina Caminada de [UNIFESP]
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:Brasil
Institución:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:inglés
OAI Identifier:oai:repositorio.unifesp.br:11600/32396
Acceso en línea:http://dx.doi.org/10.3171/2010.1.FOCUS09310
http://repositorio.unifesp.br/handle/11600/32396
Access Level:acceso abierto
Palabra clave:craniopharyngioma
interferon-alpha
hypothalamus
obesity
diabetes insipidus
Descripción
Sumario:Object. the authors assessed the efficacy of intratumoral interferon-alpha (IFN alpha)-based chemotherapy in pediatric patients with cystic craniopharyngiomas.Methods. in a prospective multicenter study of 60 pediatric patients, the authors assessed the efficacy of intratumoral INF alpha 2A-based chemotherapy. the study was conducted between 2000 and 2009 at 3 locations: the Medical School of the Federal University of São Paulo, Catholic University of Rome, and the Neurosurgery Institute of Santiago, Chile. the assessment included clinical and radiological control examinations, side effects observed, and total dose used.Results. Sixty cases of cystic craniopharyngioma were analyzed. the cohort consisted of 35 male and 25 female children (mean age 11 years). Clinical and radiological improvement was achieved in 76% of the cases. New endocrinological deficits were observed in 13% of the cases. in approximately 30% of the patients, the evolution included some light side effects, the most common being headache (33%) and eyelid edema (28%). the number of cycles varied from 1 to 9 (mean 5 cycles), and the total dose applied per cycle was 36,000,000 IU.Conclusions. This has been the largest documented series of intratumoral chemotherapy using INF alpha for the control of cystic craniopharyngiomas. the treatment has proved efficacious; there was no mortality, and morbidity rates were low. (DOI: 10.3171/2010.1.FOCUS09310)

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