Etiologic treatment of Chagas disease in Brazil
Our research group has experience in monitoring adverse reactions in Chagasdisease patients in treatment with benznidazole. This article was born out of needfor a review that incorporated different aspects pertaining to the etiologic treatmentof Chagas disease. To this end, a search of original arti...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2008 |
| País: | Brasil |
| Institución: | Universidade Federal de Goiás (UFG) |
| Repositorio: | Revista de patologia tropical (Online) |
| Idioma: | portugués |
| OAI Identifier: | oai:ojs.revistas.ufg.br:article/5063 |
| Acceso en línea: | https://revistas.ufg.br/iptsp/article/view/5063 |
| Access Level: | acceso abierto |
| Palabra clave: | Treatment Chagas disease Drug adverse reactions Benznidazole Nifurtimox. Tratamento etiológico Doença de Chagas Reações adversas a medicamentos Benznidazol Doenças Infecciosas e Parasitárias |
| Sumario: | Our research group has experience in monitoring adverse reactions in Chagasdisease patients in treatment with benznidazole. This article was born out of needfor a review that incorporated different aspects pertaining to the etiologic treatmentof Chagas disease. To this end, a search of original articles and revision papersindexed to Medline and Lilacs, and other publications related to the topic wasundertaken. Nifurtimox and benznidazole, two chemotherapeutic agents currentlyused in Chagas disease patients, have an efficacy higher than 80% in the acutephase, however only 8 to 30% in the chronic phase. The success of treatment maybe reduced due to various limitations of the currently available drugs, such asprolonged therapeutic scheme, adverse reactions and parasite genetic variability,including the existence of T. cruzi strains naturally resistant to these drugs. Thisreview reveals the necessity of development of new anti-T.cruzi drugs with lowertoxicity and higher effectiveness in the chronic phase. |
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