End-tidal CO<SUB>2</SUB> pressure determinants during hemorrhagic shock

Objectives: To examine the relationship between end-tidal CO2 (PETCO2) and its physiological determinants, pulmonary blood flow (cardiac output, CO) and CO2 production (VCO2), in a model of hemorrhagic shock during fixed minute ventilation. Design and setting: Prospective, observational study in a r...

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Autores: Dubin, Arnaldo, Murias, Gastón, Estenssoro, Elisa, Canales, Héctor Saúl, Sottile, Juan Pablo, Badie, Julio Ezequiel, Barán, Marcelo, Rossi, Silvio, Laporte, Mercedes, Palizas, Fernando, Giampieri, Jorge, Mediavilla, Diego, Vacca, Esteban, Botta, Diego
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2000
País:Argentina
Institución:Universidad Nacional de La Plata
Repositorio:SEDICI (UNLP)
Idioma:inglés
OAI Identifier:oai:sedici.unlp.edu.ar:10915/141614
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/141614
Access Level:acceso abierto
Palabra clave:Medicina
Ciencias Médicas
Capnography
End-tidal CO 2 pressure
CO 2 production
Cardiac output
Hemorrhagic shock
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spelling End-tidal CO<SUB>2</SUB> pressure determinants during hemorrhagic shockDubin, ArnaldoMurias, GastónEstenssoro, ElisaCanales, Héctor SaúlSottile, Juan PabloBadie, Julio EzequielBarán, MarceloRossi, SilvioLaporte, MercedesPalizas, FernandoGiampieri, JorgeMediavilla, DiegoVacca, EstebanBotta, DiegoMedicinaCiencias MédicasCapnographyEnd-tidal CO 2 pressureCO 2 productionCardiac outputHemorrhagic shockObjectives: To examine the relationship between end-tidal CO2 (PETCO2) and its physiological determinants, pulmonary blood flow (cardiac output, CO) and CO2 production (VCO2), in a model of hemorrhagic shock during fixed minute ventilation. Design and setting: Prospective, observational study in a research laboratory at a university center. Subjects and interventions: Six anesthetized, intubated, and mechanically ventilated mongrel dogs. Progressive stepwise bleeding. Measurements and results: We continuously measured PETCO2 with a capnograph, pulmonary artery blood flow with an electromagnetic flow probe, arterial oxygen saturation (SaO2) with a fiberoptic catheter, and oxygen consumption (VO2) and VCO2 by expired gases analysis. Oxygen delivery (DO2) was continuously calculated from pulmonary blood flow and SaO2. We studied the correlation of PETCO2 with CO and VCO2 in each individual experiment. We also calculated the critical point in the relationships PETCO2/DO2 and VO2/DO2 by the polynomial method. As expected, PETCO2 was correlated with CO. The best fit was logarithmic in all experiments (median r 2=0.90), showing that PETCO2 decrease is greater in lowest flow states. PETCO2 was correlated with VCO2, but the best fit was linear (median r 2=0.77). Critical DO2 for PETCO2 and VO2 was 8.0±3.3 and 6.3±2.5 ml.min–1.kg–1, respectively (NS). Conclusions: Our data reconfirm the relationship between PETCO2 and CO during hemorrhagic shock. The relatively greater decrease in PETCO2 at lowest CO levels could represent diminished CO2 production during the period of VO2 supply dependency.Facultad de Ciencias Médicas2000-10-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1619-1623http://sedici.unlp.edu.ar/handle/10915/141614enginfo:eu-repo/semantics/altIdentifier/issn/0342-4642info:eu-repo/semantics/altIdentifier/issn/1432-1238info:eu-repo/semantics/altIdentifier/doi/10.1007/s001340000669info:eu-repo/semantics/altIdentifier/pmid/11193267info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2024-05-08T13:10:31Zoai:sedici.unlp.edu.ar:10915/141614Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292024-05-08 13:10:31.525SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv End-tidal CO<SUB>2</SUB> pressure determinants during hemorrhagic shock
title End-tidal CO<SUB>2</SUB> pressure determinants during hemorrhagic shock
spellingShingle End-tidal CO<SUB>2</SUB> pressure determinants during hemorrhagic shock
Dubin, Arnaldo
Medicina
Ciencias Médicas
Capnography
End-tidal CO 2 pressure
CO 2 production
Cardiac output
Hemorrhagic shock
title_short End-tidal CO<SUB>2</SUB> pressure determinants during hemorrhagic shock
title_full End-tidal CO<SUB>2</SUB> pressure determinants during hemorrhagic shock
title_fullStr End-tidal CO<SUB>2</SUB> pressure determinants during hemorrhagic shock
title_full_unstemmed End-tidal CO<SUB>2</SUB> pressure determinants during hemorrhagic shock
title_sort End-tidal CO<SUB>2</SUB> pressure determinants during hemorrhagic shock
dc.creator.none.fl_str_mv Dubin, Arnaldo
Murias, Gastón
Estenssoro, Elisa
Canales, Héctor Saúl
Sottile, Juan Pablo
Badie, Julio Ezequiel
Barán, Marcelo
Rossi, Silvio
Laporte, Mercedes
Palizas, Fernando
Giampieri, Jorge
Mediavilla, Diego
Vacca, Esteban
Botta, Diego
author Dubin, Arnaldo
author_facet Dubin, Arnaldo
Murias, Gastón
Estenssoro, Elisa
Canales, Héctor Saúl
Sottile, Juan Pablo
Badie, Julio Ezequiel
Barán, Marcelo
Rossi, Silvio
Laporte, Mercedes
Palizas, Fernando
Giampieri, Jorge
Mediavilla, Diego
Vacca, Esteban
Botta, Diego
author_role author
author2 Murias, Gastón
Estenssoro, Elisa
Canales, Héctor Saúl
Sottile, Juan Pablo
Badie, Julio Ezequiel
Barán, Marcelo
Rossi, Silvio
Laporte, Mercedes
Palizas, Fernando
Giampieri, Jorge
Mediavilla, Diego
Vacca, Esteban
Botta, Diego
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Medicina
Ciencias Médicas
Capnography
End-tidal CO 2 pressure
CO 2 production
Cardiac output
Hemorrhagic shock
topic Medicina
Ciencias Médicas
Capnography
End-tidal CO 2 pressure
CO 2 production
Cardiac output
Hemorrhagic shock
description Objectives: To examine the relationship between end-tidal CO2 (PETCO2) and its physiological determinants, pulmonary blood flow (cardiac output, CO) and CO2 production (VCO2), in a model of hemorrhagic shock during fixed minute ventilation. Design and setting: Prospective, observational study in a research laboratory at a university center. Subjects and interventions: Six anesthetized, intubated, and mechanically ventilated mongrel dogs. Progressive stepwise bleeding. Measurements and results: We continuously measured PETCO2 with a capnograph, pulmonary artery blood flow with an electromagnetic flow probe, arterial oxygen saturation (SaO2) with a fiberoptic catheter, and oxygen consumption (VO2) and VCO2 by expired gases analysis. Oxygen delivery (DO2) was continuously calculated from pulmonary blood flow and SaO2. We studied the correlation of PETCO2 with CO and VCO2 in each individual experiment. We also calculated the critical point in the relationships PETCO2/DO2 and VO2/DO2 by the polynomial method. As expected, PETCO2 was correlated with CO. The best fit was logarithmic in all experiments (median r 2=0.90), showing that PETCO2 decrease is greater in lowest flow states. PETCO2 was correlated with VCO2, but the best fit was linear (median r 2=0.77). Critical DO2 for PETCO2 and VO2 was 8.0±3.3 and 6.3±2.5 ml.min–1.kg–1, respectively (NS). Conclusions: Our data reconfirm the relationship between PETCO2 and CO during hemorrhagic shock. The relatively greater decrease in PETCO2 at lowest CO levels could represent diminished CO2 production during the period of VO2 supply dependency.
publishDate 2000
dc.date.none.fl_str_mv 2000-10-18
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/141614
url http://sedici.unlp.edu.ar/handle/10915/141614
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0342-4642
info:eu-repo/semantics/altIdentifier/issn/1432-1238
info:eu-repo/semantics/altIdentifier/doi/10.1007/s001340000669
info:eu-repo/semantics/altIdentifier/pmid/11193267
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
1619-1623
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 15,812429

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