CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes

Fil: Martin, Diana L. University of Georgia. Center for Tropical and Emerging Global Diseases; Estados Unidos.

Detalhes bibliográficos
Autores: Martin, Diana L., Weatherly, Brent D., Laucella, Susana A., Cabinian, Melissa A., Crim, Matthew T., Sullivan, Susan, Heiges, Mark, Craven, Sarah H., Rosenberg, Charles S., Collins, Matthew H., Sette, Alessandro, Postan, Miriam, Tarleton, Rick
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2006
País:Argentina
Recursos:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
Repositório:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Idioma:inglês
OAI Identifier:oai:sgc.anlis.gob.ar:123456789/395
Acesso em linha:http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.0020077
http://sgc.anlis.gob.ar/handle/123456789/395
Access Level:Acceso aberto
Palavra-chave:Trypanosoma cruzi
Epítopos
Linfocitos T
Enfermedad de Chagas
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spelling CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopesMartin, Diana L.Weatherly, Brent D.Laucella, Susana A.Cabinian, Melissa A.Crim, Matthew T.Sullivan, SusanHeiges, MarkCraven, Sarah H.Rosenberg, Charles S.Collins, Matthew H.Sette, AlessandroPostan, MiriamTarleton, RickTrypanosoma cruziEpítoposLinfocitos TEnfermedad de ChagasFil: Martin, Diana L. University of Georgia. Center for Tropical and Emerging Global Diseases; Estados Unidos.Fil: Weatherly, D. Brent. University of Georgia. Center for Tropical and Emerging Global Diseases; Estados Unidos.Fil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Cabinian, Melissa A. University of Georgia. Department of Microbiology; Estados Unidos.Fil: Crim, Matthew T. University of Georgia. Department of Cellular Biology; Estados Unidos.Fil: Sullivan, Susan. University of Georgia. Department of Cellular Biology; Estados Unidos.Fil: Heiges, Mark. University of Georgia. Center for Tropical and Emerging Global Diseases; Estados Unidos.Fil: Craven, Sarah H. University of Georgia. Department of Microbiology; Estados Unidos.Fil: Rosenberg, Charles S. University of Georgia. Center for Tropical and Emerging Global Diseases; Estados Unidos.Fil: Collins, Matthew H. University of Georgia. Department of Cellular Biology; Estados Unidos.Fil: Sette, Alessandro. La Jolla Institute for Allergy and Immunology; Estados Unidos.Fil: Postan, Miriam. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Tarleton, Rick L. University of Georgia. Center for Tropical and Emerging Global Diseases; Estados Unidos.CD8+ T cells are crucial for control of a number of medically important protozoan parasites, including Trypanosoma cruzi, the agent of human Chagas disease. Yet, in contrast to the wealth of information from viral and bacterial infections, little is known about the antigen specificity or the general development of effector and memory T-cell responses in hosts infected with protozoans. In this study we report on a wide-scale screen for the dominant parasite peptides recognized by CD8+ T cells in T. cruzi–infected mice and humans. This analysis demonstrates that in both hosts the CD8+ T-cell response is highly focused on epitopes encoded by members of the large trans-sialidase family of genes. Responses to a restricted set of immunodominant peptides were especially pronounced in T. cruzi–infected mice, with more than 30% of the CD8+ T-cell response at the peak of infection specific for two major groups of trans-sialidase peptides. Experimental models also demonstrated that the dominance patterns vary depending on the infective strain of T. cruzi, suggesting that immune evasion may be occurring at a population rather than single-parasite level.2006info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf1553-7374http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.0020077http://sgc.anlis.gob.ar/handle/123456789/395PLoS pathogens, 2006, 2(8), e77.reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLISPlos Pathogensenginfo:eu-repo/semantics/openAccess2024-05-10T11:51:36Zoai:sgc.anlis.gob.ar:123456789/395Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2024-05-10 11:51:37.078Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes
title CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes
spellingShingle CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes
Martin, Diana L.
Trypanosoma cruzi
Epítopos
Linfocitos T
Enfermedad de Chagas
title_short CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes
title_full CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes
title_fullStr CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes
title_full_unstemmed CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes
title_sort CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes
dc.creator.none.fl_str_mv Martin, Diana L.
Weatherly, Brent D.
Laucella, Susana A.
Cabinian, Melissa A.
Crim, Matthew T.
Sullivan, Susan
Heiges, Mark
Craven, Sarah H.
Rosenberg, Charles S.
Collins, Matthew H.
Sette, Alessandro
Postan, Miriam
Tarleton, Rick
author Martin, Diana L.
author_facet Martin, Diana L.
Weatherly, Brent D.
Laucella, Susana A.
Cabinian, Melissa A.
Crim, Matthew T.
Sullivan, Susan
Heiges, Mark
Craven, Sarah H.
Rosenberg, Charles S.
Collins, Matthew H.
Sette, Alessandro
Postan, Miriam
Tarleton, Rick
author_role author
author2 Weatherly, Brent D.
Laucella, Susana A.
Cabinian, Melissa A.
Crim, Matthew T.
Sullivan, Susan
Heiges, Mark
Craven, Sarah H.
Rosenberg, Charles S.
Collins, Matthew H.
Sette, Alessandro
Postan, Miriam
Tarleton, Rick
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trypanosoma cruzi
Epítopos
Linfocitos T
Enfermedad de Chagas
topic Trypanosoma cruzi
Epítopos
Linfocitos T
Enfermedad de Chagas
description Fil: Martin, Diana L. University of Georgia. Center for Tropical and Emerging Global Diseases; Estados Unidos.
publishDate 2006
dc.date.none.fl_str_mv 2006
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 1553-7374
http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.0020077
http://sgc.anlis.gob.ar/handle/123456789/395
identifier_str_mv 1553-7374
url http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.0020077
http://sgc.anlis.gob.ar/handle/123456789/395
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Plos Pathogens
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv PLoS pathogens, 2006, 2(8), e77.
reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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score 15,812429

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